Disease landscape

Heart Disease clinical trials

Get alerts when Heart Disease trials change

1,456 active trials 822 recruiting 59 Phase 3 771 sponsors 163 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 51 of 163 changes on 19 trials

2026-08-22
Trial status changed: Not Yet Recruiting → Terminated
Trial terminated: Inadequate study design which restricted study enrollment suitable for a registry.
Primary completion pushed: 2023-10 → 2024-07-09
Enrollment reduced: 600 → 24 participants
Completion moved earlier: 2027-10 → 2024-07-09
NCT05536310 TAVIS Registry - Trilogy Heart Valve System for Management of Patients With Aortic Valve… · JenaValve Technology, Inc.
2026-08-11
Trial terminated
Trial terminated: diminished funding
Primary completion moved earlier: 2026-09-20 → 2026-02-09
Completion moved earlier: 2026-09-20 → 2026-02-09
NCT05201014 Cancer Survivor Cardiomyopathy Detection · Mayo Clinic
2026-08-28
Primary completion pushed: 2025-12-22 → 2026-12
Completion pushed: 2025-12-22 → 2026-12
NCT05162742 Colchicine and Inflammation in Aortic Stenosis · Radboud University Medical Center · Phase 3
2026-08-28
Primary completion pushed: 2026-08-28 → 2027-03-31
Completion pushed: 2027-02-28 → 2027-08-31
NCT05288790 Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT · Vanderbilt University Medical Center · Phase 2
2026-08-11
Primary completion pushed: 2027-01 → 2027-09
Recruitment opened
Completion pushed: 2032-01 → 2032-09
NCT07130994 Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US) · InnovHeart
2026-08-22
Primary completion pushed: 2026-07 → 2027-02
Enrollment reduced: 20 → 18 participants
Trial status changed: Enrolling by Invitation → Recruiting
Completion pushed: 2026-07 → 2027-11
NCT05585125 A Preliminary Study for INFORMED · Weill Medical College of Cornell University · Phase 4
2026-08-19
Primary completion pushed: 2027-07-31 → 2028-08-31
Completion pushed: 2027-07-31 → 2028-08-31
NCT07031531 Effectiveness of an AI-Enabled Stratified Management System for Premature Coronary Artery… · China National Center for Cardiovascular Diseases
2026-08-25
Primary completion pushed: 2027-03-31 → 2028-03-31
Completion pushed: 2027-03-31 → 2028-03-31
NCT06938412 Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial… · Icahn School of Medicine at Mount Sinai
2026-08-14
Primary completion pushed: 2026-07-31 → 2027-07-31
Completion pushed: 2026-07-31 → 2027-07-31
NCT03372733 Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults · National Heart, Lung, and Blood Institute (NHLBI) · Phase 2
2026-08-22
Primary completion pushed: 2026-05-31 → 2028-05-31
Completion pushed: 2026-05-31 → 2028-05-31
NCT00542438 Home-Based Measures of Physical Activity and Body Composition · M.D. Anderson Cancer Center
2026-08-21
Primary completion pushed: 2026-09 → 2027-09
Completion pushed: 2027-03 → 2028-09
NCT06511505 NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial · Northwestern University
2026-08-21
Primary completion pushed: 2027-06-30 → 2029-12-31
Completion pushed: 2030-01-01 → 2030-12-31
NCT03217006 Randomization of Single vs Multiple Arterial Grafts · Weill Medical College of Cornell University
2026-08-08
Primary completion pushed: 2025-07-01 → 2026-12
NCT07061145 A Potential Relationship Between Treatment With Tyrosine Kinase Inhibitors and Erectile… · Azienda USL Reggio Emilia - IRCCS
2026-08-06
Primary completion pushed: 2026-06-30 → 2027-06-30
Completion pushed: 2026-06-30 → 2027-06-30
NCT04216927 NO During CPB in Neonates to Reduce Risk of AKI · Children's Hospital Medical Center, Cincinnati · Phase 3
2026-07-31
Primary completion pushed: 2027-10 → 2028-10
Completion pushed: 2028-01 → 2029-02
NCT06711666 Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease · Institut National de la Santé Et de la Recherche Médicale, France
2026-07-31
Primary completion pushed: 2026-03-01 → 2026-10-01
Completion pushed: 2026-08-01 → 2027-06-01
NCT04053088 SAVR: IMPACT of Pre-existing Comorbidities on Patient Outcomes and Prosthetic Valve… · Institut für Pharmakologie und Präventive Medizin
2026-08-20
Primary completion pushed: 2026-06 → 2026-11
Completion pushed: 2026-06 → 2026-12
NCT06891911 Groceries for Residents of Southeastern USA to Stop Hypertension · Beth Israel Deaconess Medical Center
2026-08-20
Primary completion pushed: 2025-08-03 → 2026-09
Primary endpoint(s) modified
Trial status changed: Unknown → Recruiting
Completion pushed: 2026-02-03 → 2027-03
NCT06511505 NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial · Northwestern University
2026-08-20
Primary completion pushed: 2027-03 → 2028-01
Enrollment reduced: 790 → 564 participants
Recruitment opened
Completion pushed: 2027-04 → 2028-04
NCT07332468 Digital Remote Management for Care and Continuous Optimization Versus Usual Care to… · Beijing Anzhen Hospital
2026-08-08
Primary completion pushed: 2026-06-01 → 2027-10-01
Completion pushed: 2026-12-01 → 2027-12-01
NCT04040452 Continuous vs Intermittent Ketorolac for Pain Control in Peds CV Surgery · Phoenix Children's Hospital · Phase 4

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07791069 International Multicenter Outcomes of Transcatheter Pulmonary Flow Restrictors in… Fondation Hôpital Saint-Joseph new
2026-08-25 NCT07783607 MM-CARE: Cardiovascular Risk Assessment in Adults With Multiple Myeloma University of Vermont Medical Center new
2026-08-24 NCT07781280 Healthy Heart, Healthy Life" Program on Cardiovascular Health Behaviors Bilecik Seyh Edebali Universitesi new
2026-08-21 NCT07780552 CHIP in Health and Disease VASCage GmbH new
2026-08-19 NCT07773064 Identification for High Risk of Coronary Heart Disease Based on Quantitative Analysis of… Beijing Hospital new
2026-08-18 NCT07770269 Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery AHEPA University Hospital new
2026-08-18 NCT07770737 Cardioprotective Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Korean… Dongtan Sacred Heart Hospital new
2026-08-18 NCT07771491 Localized Evidence of Cytokine Adsorption Therapy During Pediatric Cardiac Surgery: A… Norfaniza Zabidi new
2026-08-17 NCT07769190 Cardiovascular Mortality Prediction in Maintenance Hemodialysis Patients Huashan Hospital new
2026-08-13 NCT07762898 Sedentary Behavior Intervention for Older Adults With Coronary Heart Disease and Frailty Gansu University of Chinese Medicine new

Active trials by phase

Early Phase 1
7
Phase 1
13
Phase 1/2
13
Phase 2
39
Phase 2/3
5
Phase 3
54
Phase 4
59
Not charted: 1,266 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,456

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05585125 A Preliminary Study for INFORMED Weill Medical College of Cornell University Recruiting 2026-08-21
NCT04715568 Secondhand Tobacco Smoke and Cardiovascular Disease University of California, San Francisco Recruiting 2026-08-19
NCT06578234 Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses Region Skane Recruiting 2026-08-13
NCT04040452 Continuous vs Intermittent Ketorolac for Pain Control in Peds CV Surgery Phoenix Children's Hospital Recruiting 2026-08-12
NCT07482943 The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After… The University of Hong Kong Recruiting 2026-07-28
NCT06676280 ASpirin Use and stAtin Strategy for Primary Prevention in Severe Coronary Calcium Score… Jung-min Ahn Recruiting 2026-07-01
NCT04262206 Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults Duke University Recruiting 2026-06-04
NCT06281665 Treatment With Aspirin After Preeclampsia: TAP Trial Malamo Countouris Recruiting 2026-06-04
NCT07581808 Dual PCSK9 Inhibition With Inclisiran and Alirocumab in Secondary Prevention University Medical Centre Ljubljana Recruiting 2026-06-02
NCT04263038 Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated… Drahomir Aujesky Recruiting 2026-05-22
NCT07034690 Study to Evaluate the Impact of a Targeted Lipid Optimization Program on LDL-C Control in… Novartis Pharmaceuticals Recruiting 2026-05-04
NCT07485283 Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia Tor Biering-Sørensen Recruiting 2026-05-04
NCT05786417 LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple… Yale University Recruiting 2026-04-07
NCT06336317 Effect of infLuenza vaccInation After Myocardial INfArction on Cardiac inflammaTory… Region Örebro County Recruiting 2026-04-07
NCT07370688 Iron Infusion in Patients Undergoing Transcatheter Aortic Valve Implantation Erasmus Medical Center Recruiting 2026-01-27
NCT06625073 Randomized Trial of SGLT2i in Heart Transplant Recipients VA Office of Research and Development Recruiting 2026-01-22
NCT07356778 A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired… Kazuya Hosokawa Recruiting 2026-01-21
NCT07110415 Efficacy and Safety Trials of Yangxinshi Tablets in the Treatment of Patients With… SPH Qingdao Growful Pharmacetical Co.,Ltd Recruiting 2025-11-25
NCT03770312 Low- and Moderate-intensity Statin and Clinical Outcome of Primary Prevention in… Yonsei University Recruiting 2025-11-18
NCT06263452 Beta-Blocker Influences on Inflammatory and Neural Responses to Stress University of North Carolina, Chapel Hill Recruiting 2025-10-29
NCT06260059 Efficacy Of Sodium Glucose Transporter Inhibitor (SGLT2I) In Adult Patients With… Anita Saraf Recruiting 2025-10-06
NCT06425120 Effect of Xuesaitong Soft Capsules on Major Risk Factors in Patients With Coronary Heart… China National Center for Cardiovascular Diseases Recruiting 2025-09-08
NCT05242315 Extended-Release Tacrolimus Following Liver Transplantation University of Alberta Recruiting 2025-08-21
NCT07026539 Effect of Treatment With Finerenone on Cardio-Renal Target Organ Damage in Patients With… University of Aarhus Recruiting 2025-06-24
NCT06606821 The Effects of Tirzepatide in People With Overweight/Obesity and Coronary Artery Disease Tina Vilsbøll Recruiting 2025-05-22
See all 1,456 active Heart Disease trials with filters →

Top sponsors by active trials in this area

China National Center for Cardiovascular Diseases (20) · Beijing Anzhen Hospital (16) · Mayo Clinic (15) · National Heart, Lung, and Blood Institute (NHLBI) (14) · Yonsei University (13) · Assiut University (12) · Fundación EPIC (12) · Novartis Pharmaceuticals (11) · Boston Children's Hospital (10) · Children's Hospital Medical Center, Cincinnati (10)

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