Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT05786417 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

Study acronym: LIVEBETTER
StatusRecruiting
PhasePhase 4
Started2023-05-10
View on ClinicalTrials.gov ↗

Amendment history

2026-04-06
Study Status, Contacts/Locations v8
Study sites9→10
2025-11-25
Study Status, Study Design, Outcome Measures, Eligibility v7
Enrollment target960→741
Eligibility criteria-30 characters
Inclusion Criteria: OLDER ADULTS WITH SIHD AND MCC Age ≥70 years; ≥65 years for underrepresented minorities (URM) of black race or Hispanic ethnicity ≥ 2 Multiple Chronic Conditions as defined by Centers for M [...] sion Criteria: OLDER ADULTS WITH SIHD AND MCC Current taking (both) a beta-blocker orAND a calcium channel blocker* Contraindication to beta-blockers [...] on Plans for complete revascularization within 2 weeks Clear clinical indication for beta-blockers or calcium channel blockers includingthat precludes dose adjustment or crossover: Diagnosis of acute coronary syndrome (ACS) with reduced ej [...]
Secondary endpointsdetails revised at 4 of 6 entries
2025-02-05
Study Status, Contacts/Locations v6
Study sitesdetails revised at 2 of 9 sites
2025-01-02
Study Status, Study Description v5
Study description+886 characters
[...] data on caregiver burden in older adults with stable angina. Cognition as measured by the Telephone Interview for Cognitive Status (TICS) is an exploratory endpoint included in the parent LIVEBETTER study. In November 2024, additional exploratory neurocognitive study measures were added as part of an ancillary neurocognitive study funded by the National Inst [...]
2024-11-05
Study Identification, Study Status, Eligibility, Contacts/Locations v4
Study sites7→9
Eligibility criteria+31 characters
[...] ckers including: Diagnosis of acute coronary syndrome (ACS) with reduced ejection fraction within past year Heart failure with reduced ejection fractio [...]
Show 3 earlier versions
2024-04-19
Study Identification, Study Status, Study Description, Study Design, Eligibility, Contacts/Locations v3
Eligibility criteria+84 characters
Inclusion Criteria: OLDER ADULTS WITH SIHD AND MCC Age ≥ 7570 years; ≥65 years for underrepresented minorities (URM) of black race or Hispanic ethnicity ≥ 2 Multiple Chronic Conditions as defined by Centers for M [...]
Study description-12 characters
[...] rapy versus Calcium Channel Blocker therapy in older adults (≥75 years) with symptomatic SIHD and MCC with plans to initiate medical [...]
Study sitesdetails revised at 2 of 7 sites
Study title-26 characters
LIVEBETTER: A Trial Comparing the Effectiveness and Tolerability of Medications in Older Adults With Stable Angina and Multiple Chronic Conditions
2024-01-16
Study Status, Study Design, Contacts/Locations v2
Enrollment target750→960
Study sites5→7
2023-05-17
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2023-04→confirmed 2023-05-10
Study sitesdetails revised at 5 of 5 sites
2023-03-23
Original filing
Yale University
487 trials monitored
See 35 trials at risk
Heart Disease
2,117 trials monitored
See 101 trials at risk
To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple chronic conditions (MCC).
Trial Details
NCT Number NCT05786417
Lead Sponsor Yale University
Conditions Angina, Stable Ischemic Heart Disease
Enrollment 741 participants
Start Date 2023-05-10
Primary Completion 2027-05-30 (estimated)
Study Completion 2027-05-30 (estimated)
Updated on ClinicalTrials.gov 2026-04-07