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Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses

Study acronym: HYPER
StatusRecruiting
PhasePhase 4
Started2024-10-23
View on ClinicalTrials.gov ↗

Amendment history

2026-08-12
minor
3 amendments v2-v4
3 re-verifications since 2025-06-25, no change to tracked fields
2024-10-29
notable
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start date2024-09-30→2024-10-23
Study sites0→1
2024-08-27
minor
Original filing
146 trials monitored
See 5 trials at risk
2,117 trials monitored
See 101 trials at risk
Adenosine is a commonly used pharmaceutical stressor at cardiac magnetic resonance examinations to assess suspected chronic coronary syndrome (CCS). However, several studies have reported that the current use of adenosine does not induce adequate hyperemic response in a substantial number of patients, leading to false diagnostics. The aim of this trial is to investigate the hyperemic effect of the standard dose of adenosine (140 microgram/kg/min) to the high dose of adenosine (210 microgram/kg/min) to improve the diagnostic methods using adenosine as a stressor and ultimately improve treatment decisions and patient prognosis in CCS.
Trial Details
NCT Number NCT06578234
Lead Sponsor Region Skane
Conditions Chronic Coronary Syndrome, Coronary Artery Disease, Ischemic Heart Disease
Enrollment 180 participants
Start Date 2024-10-23
Primary Completion 2026-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-13