Effect of infLuenza vaccInation After Myocardial INfArction on Cardiac inflammaTory responsE

The goal of this randomized, double-blind, placebo-controlled clinical trial is to investigate the immunological effects of influenza vaccination outside of the influenza season on arterial inflammation in patients with a recent acute myocardial infarction (AMI). The primary objective is to compare the effects of influenza vaccination to those of a placebo in reducing post-myocardial infarction coronary inflammation as measured by coronary computed tomography angiography (CCTA). The main questions it aims to answer are: Does influenza vaccination reduce arterial inflammation as measured by CCTA at week 8 after percutaneous coronary intervention (PCI) in comparison to baseline? Does influenza vaccination modulate systemic inflammation as measured by blood biomarkers and in-vitro challenge tests at week 8 after PCI in comparison to baseline? Researchers will compare the effects of influenza vaccination with those of a placebo.

NCT Number	NCT06336317
Lead Sponsor	Region Örebro County Collaborators: The Swedish Heart and Lung Association, Örebro University, Sweden, University of Cambridge, Aarhus University Hospital, Cambridge University Hospitals NHS Foundation Trust
Conditions	Acute Myocardial Infarction, Cardiovascular Diseases, Inflammatory Response
Enrollment	90 participants
Start Date	2024-04-24
Primary Completion	2027-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-04-07