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Effect of infLuenza vaccInation After Myocardial INfArction on Cardiac inflammaTory responsE

Study acronym: ELIMINATE
StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

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  1. Study sites: 2 to 3
    • Collaborators: 4 to 5
    v4
  2. Study sites: 1 to 2
    • Collaborators: 3 to 4
    v3
  3. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 1
    • Start date changed from estimate of Apr 2024 to Apr 24, 2024
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this randomized, double-blind, placebo-controlled clinical trial is to investigate the immunological effects of influenza vaccination outside of the influenza season on arterial inflammation in patients with a recent acute myocardial infarction (AMI). The primary objective is to compare the effects of influenza vaccination to those of a placebo in reducing post-myocardial infarction coronary inflammation as measured by coronary computed tomography angiography (CCTA). The main questions it aims to answer are: Does influenza vaccination reduce arterial inflammation as measured by CCTA at week 8 after percutaneous coronary intervention (PCI) in comparison to baseline? Does influenza vaccination modulate systemic inflammation as measured by blood biomarkers and in-vitro challenge tests at week 8 after PCI in comparison to baseline? Researchers will compare the effects of influenza vaccination with those of a placebo.
Trial Details
NCT Number NCT06336317
Lead Sponsor Region Örebro County
Collaborators: The Swedish Heart and Lung Association, Örebro University, Sweden, University of Cambridge, Aarhus University Hospital, Cambridge University Hospitals NHS Foundation Trust
Conditions
(from sponsor)		 Acute Myocardial Infarction, Cardiovascular Diseases, Inflammatory Response
Related terms Cardiovascular Diseases, Influenza, Human
Enrollment 90 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov