Clinical Trial

Low- and Moderate-intensity Statin and Clinical Outcome of Primary Prevention in Individuals Aged >70 Years: the SCOPE-70 RCT Study

Recruiting Phase 4
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Record status
This record was last updated November 18, 2025 (before its estimated January 16, 2026 completion). Its status may not reflect the trial's current state.
Summary
One of the most effective drug in the primary prevention of cardiovascular disease is statins. The protective effects of statin on developement of cardiovascular disease has been demonstrated in elderly individuals. Since side effects of statin are more common in elderly individuals than in younger individuals, clinical guidelines recommend that use of low intensity statin is considered in elderly individuals. However, there are few randomized clinical trials evaluating the safety and efficacy of different intensity statins in elderly individuals. This is a multicenter, prospective, randomized clinical trial to compare efficacy and safety between low and high intensity statin for primary prevention of cardiovacsular disease in elderly individuals.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2018-12-06; most recent amendment 2025-11-14.
Status change: Not Yet Recruiting → Recruiting 2025-11-14
Status change: Terminated → Not Yet Recruiting 2020-02-04
Status change: Recruiting → Terminated 2020-02-02
Status change: Not Yet Recruiting → Recruiting 2019-08-28
Trial Details
NCT Number NCT03770312
Lead Sponsor Yonsei University
Conditions Healthy Elderly Individuals With High LDL-cholesterol or Risk of Cardiovascular Disease
Enrollment 724 participants
Start Date 2020-03-05
Primary Completion 2026-01-16 (estimated)
Study Completion 2026-01-16 (estimated)
Updated on ClinicalTrials.gov 2025-11-18