Disease landscape

Amyloidosis clinical trials

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206 active trials 133 recruiting 16 Phase 3 134 sponsors 27 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days

2026-08-22
Primary completion pushed: 2026-04-30 → 2027-04-30
NCT04667494 Ultrasound Therapy In Cardiac Amyloidosis · Brigham and Women's Hospital · Phase 4
2026-08-20
Primary completion pushed: 2027-09-01 → 2029-01-01
Sponsor changed: Brigham and Women's Hospital → Dana-Farber Cancer Institute
Trial sites expanded: 1 → 5 locations
Completion moved earlier: 2029-09-01 → 2029-07-01
NCT06569147 Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis · Dana-Farber Cancer Institute · Phase 1/2
2026-08-06
Primary completion pushed: 2026-07-01 → 2027-05-17
Completion pushed: 2026-07-01 → 2027-05-17
NCT03346135 Daratumumab After Stem Cell Transplant in Treating Patients With Multiple Myeloma · City of Hope Medical Center · Phase 2
2026-07-30
Enrollment reduced: 240 → 202 participants
Enrollment closed, study ongoing
NCT04850105 A Non-interventional Cohort Safety Study of Patients With hATTR-PN · Akcea Therapeutics
2026-07-30
Enrollment reduced: 20 → 14 participants
Trial status changed: Enrolling by Invitation → Completed
Primary completion pushed: 2026-03-30 → 2026-06-04
Completion moved earlier: 2026-12-31 → 2026-06-04
NCT05019027 N-of-1 for Beta-Blockers in Cardiac Amyloidosis · Weill Medical College of Cornell University · Phase 4
2026-07-30
Recruitment opened
NCT07695701 Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis · Eidos Therapeutics, a BridgeBio company · Phase 4
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07504289 CAR-NK Therapy for Cardiac Amyloidosis · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 1/2
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT04935021 Clinical Study of ATTR-CM · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 4
2026-08-04
Trial status changed: Recruiting → Enrolling by Invitation
NCT05697861 Long-Term Follow-Up (LTFU) of Subjects Dosed With NTLA-2001 · Intellia Therapeutics
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT04924998 Clinical Study for AL-CM · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-08-19
Trial status changed: Recruiting → Enrolling by Invitation
NCT07398950 Prospective Evaluation of Artificial Intelligence-enabled Screening for Transthyretin… · Yale University
2026-08-12
Primary completion pushed: 2026-09-30 → 2026-11-02
Completion pushed: 2026-09-30 → 2026-11-02
NCT06355934 OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR… · AstraZeneca
2026-08-15
Trial sites expanded: 240 → 251 locations
NCT07052903 TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With… · Alnylam Pharmaceuticals · Phase 3
2026-08-15
Trial sites expanded: 41 → 48 locations
NCT07223203 TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With… · Alnylam Pharmaceuticals · Phase 3
2026-08-20
Trial sites expanded: 82 → 89 locations
NCT06465810 Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis · AstraZeneca
2026-08-11
Enrollment increased: 5000 → 10000 participants
NCT06610019 Cardiovascular Multimodality Imaging Study · Montefiore Medical Center
2026-08-02
Trial status changed: Not Yet Recruiting → Unknown
NCT06499064 EOSS-ATTR Study (eHealth Based Operative Support System in ATTR-CM) · Hospital Universitari de Bellvitge
2026-08-02
Trial status changed: Recruiting → Unknown
NCT04587648 Cardiac Amyloidosis in HFpEF · National Taiwan University Hospital

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-25 NCT07784712 Right Ventricular Septal Biopsy to Detect Cardiac Amyloidosis Geisinger Clinic new
2026-08-18 NCT07771621 PET Imaging With [18F]Fluselenamyl in People With Cardiac Amyloidosis Washington University School of Medicine new Phase 1
2026-08-14 NCT07765524 A Phase I/II Open-label, Single-arm, Multicenter Clinical Study to Evaluate the Safety… Shenzhen Fosun Kairos Biotechnology Co., Ltd. new Phase 1/2
2026-08-14 NCT07766135 Liver and Coagulation Disorders in Cardiac Transthyretin Amyloidosis University of Messina new
2026-08-07 NCT07752732 Non-Interventional Study on the Prevalence of Cardiac Amyloidosis in Patients With… University Hospital Tuebingen new
2026-07-23 NCT07721350 Prospective Evaluation of Subcutaneous Administration of Daratumumab by the FreedomEDGE®… Hospices Civils de Lyon new
2026-07-08 NCT07689331 Hungarian National Systemic Amyloidosis Registry Semmelweis University new
2026-06-15 NCT07648303 Prevalence of Cardiac Thrombi in Cardiac Amyloidosis Centre Hospitalier Universitaire Dijon new
2026-06-12 NCT07644325 Concordance for Transthyretin Amyloidosis Between Synovial Biopsy and Anterior Carpal… Clinique Saint Jean, France new
2026-06-04 NCT07626476 Autologous BCMA-targeted CAR-T Cell Injection for Relapsed/Refractory Light Chain… Beijing Boren Hospital new Early Phase 1

Active trials by phase

Early Phase 1
4
Phase 1
9
Phase 1/2
12
Phase 2
30
Phase 3
16
Phase 4
6
Not charted: 129 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 206

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT04667494 Ultrasound Therapy In Cardiac Amyloidosis Brigham and Women's Hospital Recruiting 2026-08-21
NCT07695701 Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis Eidos Therapeutics, a BridgeBio company Recruiting 2026-07-29
NCT07306949 Real-Life Clinical Efficacy of Acoramidis in Participants With ATTR-CM and Association… Alexion Pharmaceuticals, Inc. Recruiting 2026-01-07
NCT06998875 A Prospective Cohort Study on Primary Cutaneous Amyloidosis Army Medical University, China Recruiting 2025-08-13
NCT04935021 Clinical Study of ATTR-CM Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting 2023-01-31
NCT05489523 Safety, Efficacy, and Pharmacokinetics of Tafamidis in Patients With… University of Texas Southwestern Medical Center Active, Not Recruiting 2026-06-04
Phase 3
NCT07052903 TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With… Alnylam Pharmaceuticals Recruiting 2026-08-14
NCT07223203 TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With… Alnylam Pharmaceuticals Recruiting 2026-08-14
NCT06563895 Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in… Eidos Therapeutics, a BridgeBio company Recruiting 2026-08-04
NCT07560306 [64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy Brigham and Women's Hospital Recruiting 2026-07-21
NCT06022939 Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone… SWOG Cancer Research Network Recruiting 2026-05-06
NCT06672237 A Phase 3 Study of NTLA-2001 in ATTRv-PN Intellia Therapeutics Recruiting 2026-04-16
NCT06128629 MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis… Intellia Therapeutics Recruiting 2026-03-27
NCT07388602 A Study to Evaluate the Safety and Efficacy of SCTC21C in Combination With Bortezomib… Sinocelltech Ltd. Recruiting 2026-02-05
NCT07116473 To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With… Eidos Therapeutics, a BridgeBio company Not Yet Recruiting 2026-08-11
NCT07709715 A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of NXC-201 Compared With… Nexcella Inc. Not Yet Recruiting 2026-07-16
NCT05619302 Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis Brigham and Women's Hospital Active, Not Recruiting 2026-07-06
NCT04504825 A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb… Alexion Pharmaceuticals, Inc. Active, Not Recruiting 2026-07-02
NCT04512235 A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa… Alexion Pharmaceuticals, Inc. Active, Not Recruiting 2026-06-17
NCT06679946 A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With… Alnylam Pharmaceuticals Enrolling by Invitation 2026-02-20
NCT04153149 HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With… Alnylam Pharmaceuticals Active, Not Recruiting 2026-01-12
NCT06712030 Effect of Angiotensin Receptor/Neprilysin Inhibitors on Transthyretin Cardiac Amyloidosis… Puerta de Hierro University Hospital Not Yet Recruiting 2024-12-02
Phase 2
NCT07638683 A Phase II Study to Evaluate the Efficacy and Safety of Teclistamab in Combination With… Shanghai Zhongshan Hospital Recruiting 2026-08-03
NCT07285044 The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home… Mayo Clinic Recruiting 2026-07-30
NCT07335887 Sonrotoclax Plus Dexamethasone With or Without Daratumumab Regimen in Patients With… Peking University People's Hospital Recruiting 2026-07-28
See all 206 active Amyloidosis trials with filters →

Top sponsors by active trials in this area

Alnylam Pharmaceuticals (8) · Fondazione IRCCS Policlinico San Matteo di Pavia (7) · Mayo Clinic (6) · Brigham and Women's Hospital (5) · Alexion Pharmaceuticals, Inc. (4) · AstraZeneca (4) · Peking Union Medical College Hospital (4) · University Hospital, Essen (4) · University of Texas Southwestern Medical Center (4) · Assistance Publique - Hôpitaux de Paris (3)

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