Disease landscape

Liver Cancer clinical trials

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1,162 active trials 667 recruiting 91 Phase 3 512 sponsors 139 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 48 of 139 changes on 20 trials

2026-08-19
Suspended trial terminated
NCT05435014 T-ACE Oil by TAE/TACE in Patients With Hepatocellular Carcinoma · T-ACE Medical Co., Ltd · Phase 1/2
2026-08-26
Trial terminated
Trial terminated: The decision has been made to terminate the study due to logistical reasons and not due to any safety concerns.
Primary completion pushed: 2025-12 → 2026-04-09
Enrollment reduced: 43 → 12 participants
Completion pushed: 2025-12 → 2026-04-09
NCT04601428 Hepatic IA Therapy in Stage B or Limited Stage C Hepatoma (HCC) · Koo Foundation Sun Yat-Sen Cancer Center · Early Phase 1
2026-08-18
Recruitment suspended
Recruitment suspended: Pending protocol amendment
NCT05791448 AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver… · University of Southern California · Phase 1
2026-08-26
Primary completion pushed: 2026-06-30 → 2026-10-14
Completion pushed: 2026-06-30 → 2026-10-14
NCT04770896 A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone… · Hoffmann-La Roche · Phase 3
2026-08-26
Primary completion pushed: 2026-12-31 → 2027-03-31
Completion pushed: 2026-12-31 → 2027-03-31
NCT03533582 Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With… · Children's Oncology Group · Phase 3
2026-08-18
Primary completion pushed: 2026-10-31 → 2027-09-30
Primary endpoint(s) modified
Recruitment opened
Trial sites expanded: 0 → 7 locations
Completion pushed: 2026-10-31 → 2027-10-31
NCT07209813 GKL-006 Injection Plus TACE Versus TACE Alone in Patients With Unresectable… · Beijing Gene Key Life Technology Co., Ltd · Phase 2
2026-08-28
Primary completion pushed: 2029-08-31 → 2030-08-31
Completion pushed: 2031-08-31 → 2032-08-31
NCT07691645 Shuganhuazhuo Formula for Advanced Hepatocellular Carcinoma With Damp-Heat Syndrome · Xiang-Qian · Phase 2
2026-08-05
Primary completion pushed: 2026-07 → 2027-09
Completion pushed: 2026-07 → 2027-09
Trial arms changed: 9 → 10
NCT06084481 Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With… · AbbVie · Phase 1
2026-08-21
Primary completion pushed: 2027-12-31 → 2028-12-31
Trial sites expanded: 4 → 8 locations
Completion pushed: 2029-12-31 → 2030-12-31
NCT06773845 Building Evidence for Ablative Internal Radiation Therapy in Localized HCC Beyond the… · Seoul National University Hospital · Phase 2
2026-08-21
Primary completion pushed: 2025-12-31 → 2026-07-01
Trial completed
NCT06114082 TACE Using Idarubicin Versus Doxorubicin Chemoemulsion in Patients With Hepatocellular… · Seoul National University Hospital · Phase 2
2026-08-26
Primary endpoint(s) modified
NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… · Lumina Pharmaceuticals Inc · Early Phase 1
2026-08-07
Primary completion pushed: 2028-05-30 → 2029-08-14
Completion pushed: 2028-05-30 → 2029-08-14
NCT07168668 Partial Immune-boost TACE in unrEseCTable HCC Patients Under Systemic Treatment · Chang Gung Memorial Hospital · Phase 2
2026-08-05
Primary completion pushed: 2025-12-31 → 2026-06-30
NCT05168163 Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of… · Academic and Community Cancer Research United · Phase 2
2026-08-07
Primary completion pushed: 2026-08-01 → 2027-08-01
Completion pushed: 2041-07-03 → 2042-07-03
NCT04715191 Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in… · Baylor College of Medicine · Phase 1
2026-08-22
Primary endpoint(s) modified
Recruitment opened
Enrollment increased: 56 → 299 participants
Trial sites expanded: 0 → 3 locations
Primary completion moved earlier: 2028-08 → 2027-08
Trial arms changed: 2 → 3
NCT07623369 A First-in-Human Study of HH160 in Participants With Advanced or Metastatic Solid Tumors · Huahui Health · Phase 1
2026-08-15
Primary completion pushed: 2026-06-30 → 2027-04-30
NCT04221893 Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers · University of California, San Francisco
2026-08-11
Primary completion pushed: 2028-06-30 → 2030-06-30
Completion pushed: 2029-06-30 → 2035-06-30
NCT03959800 Molecular Basis of Pediatric Liver Cancer · University of Pittsburgh
2026-08-07
Primary completion pushed: 2026-04-30 → 2027-04-30
NCT07010315 Development and Testing of a Patient-facing Educational Tool About Liver Cancer Prevention · M.D. Anderson Cancer Center
2026-08-06
Primary endpoint(s) modified
Primary completion moved earlier: 2030-06-28 → 2027-01-31
Trial arms changed: 7 → 9
NCT05176483 Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in… · Exelixis · Phase 1
2026-08-21
Primary endpoint(s) modified
Trial arms changed: 4 → 5
NCT05269381 Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for… · Mayo Clinic · Phase 1/2

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07790419 A Prospective, Single-Arm, Open-Label Clinical Study of the Efficacy and Safety of… Zhai Wenlong new Phase 4
2026-08-24 NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… Lumina Pharmaceuticals Inc new Early Phase 1
2026-08-21 NCT07780357 HCC Risk Prediction Model Based on Multimodal Data in Chronic Hepatitis B Beijing Friendship Hospital new
2026-08-17 NCT07768085 Pragmatic RCT of AI-Assisted Reading for Malignant Hepatic Lesions on CE-CT Shengjing Hospital new
2026-08-14 NCT07764835 Prospective Evaluation of Hepatocellular Carcinoma Surveillance in At-Risk Patients… D'Or Institute for Research and Education new
2026-08-12 NCT07761286 Evaluate the Safety and Efficacy of Combination Therapy With SYS6090 Injection for… CSPC Megalith Biopharmaceutical Co.,Ltd. new Phase 1/2
2026-08-12 NCT07760012 68Ga-SorB PET/CT Imaging in Patients With Solid Tumors Peking University Third Hospital new
2026-08-06 NCT07750275 Safety and Economics of Parenchymal Transection in Minimally Invasive Liver Surgery University of Molise new
2026-08-04 NCT07745153 Novel Abdominal Compression Positioning Technique for Respiratory Motion Management in… Southern Medical University, China new
2026-08-03 NCT07741903 Development of a Risk Prediction Model for Immune-Targeted Therapy-Related Diarrhea in… Affiliated Hospital of Chengde Medical University new

Active trials by phase

Early Phase 1
18
Phase 1
131
Phase 1/2
82
Phase 2
277
Phase 2/3
20
Phase 3
71
Phase 4
22
Not charted: 541 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,162

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06084234 National Liver Cancer Screening Trial University of Texas Southwestern Medical Center Recruiting 2026-08-12
NCT07059494 Atezolizumab and Bevacizumab in Combination With Y^90 Radioembolization in HCC for Liver… Icahn School of Medicine at Mount Sinai Recruiting 2026-07-28
NCT07405086 Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or… OHSU Knight Cancer Institute Recruiting 2026-06-12
NCT07150624 The Treatment of Liver Injury After Liver Resection With Polyene Phosphatidylcholine Anhui Provincial Hospital Recruiting 2026-05-11
NCT06717919 HOPE Against Cancer Recurrence in HCC Philipp Dutkowski Recruiting 2025-12-16
NCT07132515 Efficacy & Safety of Anticoagulants in Cirrhosis ± HCC Mansoura University Recruiting 2025-08-20
NCT06930573 A Study of AK112, a PD-1/ VEGF Bispecific Antibody, for Resectable Hepatocellular… The First Affiliated Hospital of Zhengzhou University Recruiting 2025-04-16
NCT04731558 Pre- Vs Postoperative Thromboprophylaxis for Liver Resection Helsinki University Central Hospital Recruiting 2025-02-14
NCT06594744 Endoscopic Variceal Ligation vs Carvedilol for the Prevention of First Esophageal… Taipei Veterans General Hospital, Taiwan Recruiting 2025-02-13
NCT06353126 DEB-TACE Prior to Liver Transplantation in the Treatment of HCC RenJi Hospital Recruiting 2024-10-18
NCT06311929 Precision Adjuvant Therapy After Surgery for Hepatocellular Carcinoma Chen Xiaoping Recruiting 2024-05-07
NCT06311942 Triple vs. Dual Adjuvant Therapy Following Liver Resection for HCC. Chen Xiaoping Recruiting 2024-05-07
NCT05185505 Atezolizumab and Bevacizumab Pre-Liver Transplantation for Patients With Hepatocellular… The Methodist Hospital Research Institute Recruiting 2023-02-01
NCT05331911 Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane… Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting 2022-11-30
NCT07790419 A Prospective, Single-Arm, Open-Label Clinical Study of the Efficacy and Safety of… Zhai Wenlong Not Yet Recruiting 2026-08-27
NCT07668570 SBRT Plus QL1706 as Second-Line Therapy for Hepatocellular Carcinoma Hebei Medical University Fourth Hospital Not Yet Recruiting 2026-06-25
NCT06923176 Effect of Biejia-Ruangan Compound on Survival Rate and Recurrence Rate of Hepatocellular… Zhiyun Yang Not Yet Recruiting 2025-04-11
NCT03024684 Statin for Preventing Hepatocellular Carcinoma Recurrence After Curative Treatment Chiayi Christian Hospital Active, Not Recruiting 2024-11-12
NCT06464380 Anti-cancer Potentiality of Saffron Against Hepatocellular Carcinoma Ain Shams University Not Yet Recruiting 2024-09-23
NCT06496815 Donafenib Combined With Immunotherapy and Local Therapy for Unresectable Hepatocellular… Tongji Hospital Not Yet Recruiting 2024-07-11
NCT06311916 Efficacy and Safety of Neoadjuvant Therapy in Patients With Resectable HCC Screened by a… Chen Xiaoping Not Yet Recruiting 2024-03-15
NCT02785380 Laparoscopic Surgery VS RFA for Recurrent HCC Sun Yat-sen University Not Yet Recruiting 2016-06-02
Phase 3
NCT07166406 Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients… NRG Oncology Recruiting 2026-08-17
NCT07475026 A Study of Neoadjuvant Tislelizumab Plus Lenvatinib in Resectable HCC at High Risk of… Tianjin Medical University Cancer Institute and Hospital Recruiting 2026-08-05
NCT06921785 Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without… AstraZeneca Recruiting 2026-07-14
See all 1,162 active Liver Cancer trials with filters →

Top sponsors by active trials in this area

Sun Yat-sen University (48) · Tongji Hospital (26) · Tianjin Medical University Cancer Institute and Hospital (22) · Second Affiliated Hospital of Guangzhou Medical University (21) · Shanghai Zhongshan Hospital (20) · West China Hospital (18) · AstraZeneca (17) · Fudan University (17) · M.D. Anderson Cancer Center (16) · National Cancer Institute (NCI) (15)

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