Disease landscape

Obesity clinical trials

Get alerts when Obesity trials change

2,466 active trials 1,277 recruiting 149 Phase 3 1,139 sponsors 373 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 57 of 373 changes on 20 trials

2026-08-05
Trial terminated
Trial terminated: Business decision.
Enrollment reduced: 100 → 2 participants
Trial sites reduced: 8 → 2 locations
Primary completion moved earlier: 2026-12 → 2026-07-30
Completion moved earlier: 2026-12 → 2026-07-30
NCT06894498 Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss · Boston Scientific Corporation
2026-08-08
Trial status changed: Suspended → Withdrawn
NCT07252037 Dietary Guidelines for Americans-Ultra Processed Study · USDA Grand Forks Human Nutrition Research Center
2026-08-08
Trial terminated
Trial terminated: Reprioritization of research efforts
Enrollment reduced: 10 → 1 participants
Primary completion moved earlier: 2027-11 → 2026-06-10
Completion moved earlier: 2028-01 → 2026-06-10
NCT06606327 Diazoxide Suppression Test P&F Study · Columbia University · Phase 1
2026-08-26
Primary completion pushed: 2026-03-26 → 2026-07-20
Trial completed
Completion pushed: 2026-05-17 → 2026-07-20
NCT06719011 A Study on How NNC0174-1213 Works in People With Overweight or Obesity. · Novo Nordisk A/S · Phase 1
2026-08-22
Primary completion pushed: 2026-02 → 2026-09
Enrollment closed, study ongoing
Completion pushed: 2026-06 → 2027-01
NCT05822544 Phase 1/1b Study of TLC-6740 in Healthy Subjects and Subjects With Obesity, With or… · OrsoBio, Inc · Phase 1
2026-08-27
Primary completion pushed: 2025-12-12 → 2026-06-04
Primary endpoint(s) modified
Enrollment reduced: 160 → 92 participants
Trial completed
Completion moved earlier: 2027-01 → 2026-06-04
NCT04599478 Pharmacological and Behavioral Treatment After Bariatric Surgery: Acute (Stage 1) · Yale University · Phase 2/3
2026-08-18
Primary completion pushed: 2026-09-24 → 2027-10-11
Trial sites expanded: 1 → 4 locations
Completion pushed: 2026-09-24 → 2027-10-11
NCT06577766 A Research Study on How NNC0638-0355, a New Medicine, Works in People Living With… · Novo Nordisk A/S · Phase 1
2026-08-08
Primary completion pushed: 2026-10 → 2027-03
Enrollment increased: 48 → 80 participants
Completion pushed: 2026-10 → 2027-03
Trial arms changed: 4 → 8
NCT07291232 A Study of ABBV-295 Subcutaneous Injections to Assess Adverse Events and Pharmacokinetics… · AbbVie · Phase 1
2026-08-15
Primary completion pushed: 2025-11 → 2026-03-01
Trial completed
Completion pushed: 2025-12 → 2026-03-01
NCT06911073 A Study to Evaluate a Postbiotic in Supporting Weight Loss and Metabolic Health · ResBiotic Nutrition, Inc.
2026-08-20
Primary completion pushed: 2026-08-04 → 2027-08-04
Completion pushed: 2026-08-04 → 2027-08-04
NCT03288207 Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in… · National Heart, Lung, and Blood Institute (NHLBI)
2026-08-26
Primary completion pushed: 2025-10 → 2028-12
Completion pushed: 2026-10 → 2029-12
NCT04326192 Brown Adipose Tissue Activation by Spinal Cord Stimulation · Oregon Health and Science University
2026-08-20
Primary completion pushed: 2026-10-15 → 2027-08-15
Trial sites reduced: 20 → 16 locations
Completion pushed: 2031-10-15 → 2032-08-15
NCT05082519 Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL · Etan Orgel · Phase 2
2026-08-22
Primary completion pushed: 2027-12 → 2029-03
Trial sites expanded: 10 → 14 locations
NCT06309238 Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and… · Carsten Dirksen
2026-08-22
Primary completion pushed: 2026-08 → 2026-12
NCT03705416 Long Term Outcomes of Bariatric Patients Treated With Surgery or Endoscopy · Johns Hopkins University
2026-08-21
Primary completion pushed: 2026-12-01 → 2027-12-01
Completion pushed: 2026-12-01 → 2027-12-01
NCT04824248 Weight Reduction in CLBP · Vrije Universiteit Brussel
2026-08-21
Primary completion pushed: 2026-04 → 2028-04
Completion pushed: 2026-11 → 2028-11
NCT05811624 Lifestyle Intervention in Overweight/Obese Chronic Low Back Pain (CLBP) Patients: an… · Vrije Universiteit Brussel
2026-08-20
Primary completion pushed: 2027-04-15 → 2027-12-05
Recruitment opened
Completion pushed: 2027-12-15 → 2028-08-05
NCT07213323 Probiotic Intervention for Digestive Health in Obese Patients Initiating GLP-RA Treatment · Hospices Civils de Lyon
2026-08-13
Primary completion pushed: 2026-05 → 2026-12-31
Enrollment closed, study ongoing
Completion pushed: 2026-06 → 2026-12-31
NCT05700916 Evaluation of Milk Polar Lipids in Dyslipidemic Adults With Abdominal Obesity · University of Connecticut · Early Phase 1
2026-07-30
Primary completion pushed: 2026-05 → 2026-12
Completion pushed: 2026-10 → 2027-05
NCT06199154 Induction of Labor in Morbidly Obese Patients · University of Maryland, Baltimore · Early Phase 1
2026-08-15
Primary completion pushed: 2026-07 → 2027-07-31
Completion pushed: 2026-12 → 2027-12-31
NCT04855552 Telehealth Weight Loss Program for Breast Cancer Survivors · Abramson Cancer Center at Penn Medicine

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07789223 Weight and Metabolic Management Study Elenzia new
2026-08-27 NCT07788963 Obesity and Outcomes After Surgery for Thoracoabdominal and Abdominal Gunshot Injuries Bakirkoy Dr. Sadi Konuk Research and Training Hospital new
2026-08-27 NCT07788833 A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Safety and… Able Biolabs, LLC new
2026-08-27 NCT07789106 A Study on Ubiquinol on Fatigue and Muscle Strength in Healthy Adults Taking GLP-1… StudySetGo new
2026-08-26 NCT07787468 Videolaryngoscopes in the Morbidly Obese Uniwersytet Radomski im. Kazimierza Pułaskiego new
2026-08-26 NCT07787936 GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry Miedziowe Centrum Zdrowia SA new
2026-08-26 NCT07787286 EMS vs. Resistance Training in Overweight Women Birjand University of Medical Sciences new
2026-08-26 NCT07787234 Investigation of Systemic Inflammation Markers in Lipedema Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey new
2026-08-26 NCT07787533 Digital Resistance Training for Midlife Women Using GLP-1 Louisiana State University and A&M College new
2026-08-24 NCT07782411 Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With… Autonomous University of Morelos new

Active trials by phase

Early Phase 1
25
Phase 1
137
Phase 1/2
32
Phase 2
145
Phase 2/3
12
Phase 3
137
Phase 4
98
Not charted: 1,880 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 2,466

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07154719 GLP-1R Actions on Muscle and the Skeleton Pennington Biomedical Research Center Recruiting 2026-08-27
NCT07554638 Incretin Therapies in Obesity-related HFpEF Columbia University Recruiting 2026-08-24
NCT07218445 The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in… Mayo Clinic Recruiting 2026-08-18
NCT07275697 Waiting on Atrial Fibrillation Intervention Therapy (WAIT) Study Emma Svennberg Recruiting 2026-08-10
NCT06374875 Fibrosis Lessens After Metabolic Surgery The Cleveland Clinic Recruiting 2026-07-31
NCT07728383 A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity Gila Therapeutics, Inc. Recruiting 2026-07-27
NCT07257484 Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors Weill Medical College of Cornell University Recruiting 2026-07-22
NCT07247084 A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants… Eli Lilly and Company Recruiting 2026-07-07
NCT06396416 Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2 Western University, Canada Recruiting 2026-06-29
NCT06864026 A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in… Eli Lilly and Company Recruiting 2026-06-11
NCT05919797 Weight Loss Study: Genetics and Response to Naltrexone/Bupropion Columbia University Recruiting 2026-06-10
NCT05320796 The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass Prof Urs Zingg Recruiting 2026-06-09
NCT05975580 Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain… University of California, Irvine Recruiting 2026-06-09
NCT06857942 A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation… Eli Lilly and Company Recruiting 2026-06-03
NCT07588438 Efficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay. Las Rías Medical Center Recruiting 2026-05-19
NCT06721507 2024 Tirzepatide-Bariatric Surgery Marlene Starr Recruiting 2026-05-14
NCT05305313 Evaluation of Propofol Dosing Based on Total Body Weight Using Closes-loop Anaesthesia… Sir Ganga Ram Hospital Recruiting 2026-04-27
NCT07096908 Tirzepatide Use in People With Obesity and Type 1 Diabetes Dasman Diabetes Institute Recruiting 2026-04-20
NCT07513168 Low-Dose Semaglutide for Weight Loss in Obese Non-Diabetic Pakistani Adults Asian Institute Of Medical Sciences Recruiting 2026-04-06
NCT05744479 Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability Centre for Addiction and Mental Health Recruiting 2026-03-31
NCT07213466 Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder Mayo Clinic Recruiting 2026-03-11
NCT07401992 Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis Hospital Universitario Dr. Jose E. Gonzalez Recruiting 2026-02-11
NCT05051436 The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics Philip Kern Recruiting 2026-02-03
NCT07163650 Evaluating Anti-Obesity Medications 6 Months After Metabolic Surgery The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting 2026-01-27
NCT06132477 Impact GLP-1 Agonists Following Bariatric University of Missouri-Columbia Recruiting 2026-01-22
See all 2,466 active Obesity trials with filters →

Top sponsors by active trials in this area

Novo Nordisk A/S (61) · Eli Lilly and Company (48) · University of Colorado, Denver (30) · Mayo Clinic (25) · Norwegian University of Science and Technology (25) · Cairo University (24) · Massachusetts General Hospital (17) · University of Alabama at Birmingham (17) · Pennington Biomedical Research Center (16) · Assistance Publique - Hôpitaux de Paris (15)

Get alerts when Obesity trials change
Status changes, date slips, and new sponsor entrants: detected daily, delivered to your inbox.
Start monitoring free