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The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity

StatusRecruiting
PhasePhase 4
Started2026-04-08
View on ClinicalTrials.gov ↗

Amendment history

2026-08-16
Study Status, Eligibility v5
Eligibility criteria+410 characters
Inclusion Criteria Postmenopausal women defined as 12 months of spontaneous amenorrhea, or 6 months of spontaneous amenorrhea with serum follicle-stimulating hormone (FSH) levels > 40 mIU/ml, or 6 weeks postsurgical bilateral oophorectomy with or without hysterectomy.Females Age 46-60 years old. BMI ≥30 kg/m2 or BMI ≥27 kg/m2 in the [...] ardiovascular disease). Presence of bothersome hot flashes (an average of ≥ 28 episodes perduring a consecutive 2-week andperiod ofwith symptom severity sufficient severity to prompthave patientsprompted the participant to seek therapeutic interventionstreatment). [...] [...]
2026-06-03
Study Status, Contacts/Locations v4
Start dateestimated 2026-04→confirmed 2026-04-08
Study sitescontacts updated at 1 of 1 site
2026-03-20
Active, Not Recruiting→Recruiting Study Status, Contacts/Locations v3
Trial statusActive, Not Recruiting→Recruiting
Start date2025-09-16→2026-04
Study sitesdetails revised at 1 of 1 site
2026-01-30
Study Status, Outcome Measures v2
Secondary endpoints6 to 14 entries
Change in VascularReactive hyperemic index Change in Augmentation Index percentage Change in Pulse Wave Velocity Change in Physical Function Measure: Short Physical Performance Battery (SPPB) score. Change in Physical Function Measure: Modified Clinical Test of Sensory Interaction in Balance (mCTSIB) performed on the Rehabilitation Artificial Physical Intelligence Database (RAPID) foot pressure mat Change in Physical Function Measure: S [...]
2025-10-28
Study Status, Oversight, References v1
Re-verified, no change to tracked fields
2025-10-16
Original filing
Mayo Clinic
1,015 trials monitored
See 115 trials at risk
Obesity
3,523 trials monitored
See 133 trials at risk
The purpose of this study is to determine the effect of tirzepatide on vasomotor symptoms and on measures of biological aging.
Trial Details
NCT Number NCT07218445
Lead Sponsor Mayo Clinic
Conditions Obesity, Menopause Hot Flashes
Enrollment 40 participants
Start Date 2026-04-08
Primary Completion 2027-09-18 (estimated)
Study Completion 2027-09-18 (estimated)
Updated on ClinicalTrials.gov 2026-08-18