Clinical Trial

GLP-1R Actions on Muscle and the Skeleton

Study acronym: GRAMS
Active, Not Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
The GRAMS study objectives are to assess the musculoskeletal changes that occur after weight loss using GLP-1 based therapy. A lifestyle intervention with diet and exercise is included to assess any mitigating effects are provided, versus a control group with regular exercise and diet.
Protocol Amendment History 3 changes
critical Trial status changed: Recruiting → Active, Not Recruiting 2026-07-25
notable Primary completion pushed: 2026-12-01 -> 2027-02-01 2026-05-30
minor Completion pushed: 2026-12-01 -> 2027-05-01 2026-05-30
Trial Details
NCT Number NCT07154719
Lead Sponsor Pennington Biomedical Research Center
Collaborators: National Institutes of Health (NIH)
Conditions Musculoskeletal Abnormalities, Obesity, Sarcopenic Obesity, Osteoporosis, Drug Effect
Enrollment 50 participants
Start Date 2025-10-09
Primary Completion 2027-02-01 (estimated)
Study Completion 2027-05-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-24