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GLP-1R Actions on Muscle and the Skeleton

Study acronym: GRAMS
StatusRecruiting
PhasePhase 4
Started
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Record History

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  1. Enrollment reopened
    • Site details revised at 2 of 2 sites
    v5
  2. Trial status changed: Recruiting → Active, Not Recruiting
    • Study sites: 1 to 2
    v4
  3. Primary completion pushed from Dec 1, 2026 to Feb 1, 2027
    • Study completion pushed from Dec 1, 2026 to May 1, 2027
    v3
  4. Phase: Phase 3 to Phase 4v2 Show 7 more changesShow less
    • Trial status: Not Yet Recruiting to Recruiting
    • Primary completion date: Mar 1, 2026 to Dec 1, 2026
    • Study completion date: Apr 1, 2026 to Dec 1, 2026
    • Start date changed from estimate of Sep 1, 2025 to Oct 9, 2025
    • Secondary endpoints: 2 to 6
    • Study site revised
    • Collaborators expanded, about 5 words
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The GRAMS study objectives are to assess the musculoskeletal changes that occur after weight loss using GLP-1 based therapy. A lifestyle intervention with diet and exercise is included to assess any mitigating effects are provided, versus a control group with regular exercise and diet.
Trial Details
NCT Number NCT07154719
Lead Sponsor Pennington Biomedical Research Center
Collaborators: National Institutes of Health (NIH)
Conditions
(from sponsor)		 Musculoskeletal Abnormalities, Obesity, Sarcopenic Obesity, Osteoporosis, Drug Effect
Related terms Musculoskeletal Abnormalities, Obesity, Osteoporosis
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov