Disease landscape

Hypertension clinical trials

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1,539 active trials 815 recruiting 93 Phase 3 816 sponsors 206 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 51 of 206 changes on 20 trials

2026-07-31
Trial status changed: Not Yet Recruiting → Terminated
Trial terminated: Insufficient enrollment
Primary completion pushed: 2026-03 → 2026-07-22
Enrollment reduced: 68 → 11 participants
Completion pushed: 2026-05 → 2026-07-22
NCT07124728 Syntrillo Telehealth Stroke Risk Reduction Study · Syntrillo, Inc
2026-08-25
Primary completion pushed: 2025-12 → 2026-06-09
Trial completed
Completion pushed: 2025-12 → 2026-06-09
NCT07117474 Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Subcutaneous… · Fujian Shengdi Pharmaceutical Co., Ltd. · Phase 1
2026-08-18
Primary completion pushed: 2027-04 → 2028-03
Phase changed: Phase 1 → Phase 1/2
Recruitment opened
Enrollment increased: 40 → 90 participants
Completion pushed: 2028-01 → 2028-11
NCT07143448 A Study of HS235 for Treatment of Pulmonary Arterial Hypertension (PAH) in Adults · 35Pharma Inc · Phase 1/2
2026-08-18
Primary completion pushed: 2027-09 → 2029-01
Phase changed: Phase 1 → Phase 1/2
Recruitment opened
Enrollment increased: 40 → 126 participants
Completion pushed: 2028-09 → 2030-01
NCT07123779 HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With… · 35Pharma Inc · Phase 1/2
2026-08-01
Primary completion pushed: 2026-07 → 2026-12
Enrollment closed, study ongoing
NCT07297797 Phase II Clinical Study of HRS-9563 in Patients With Mild to Moderate Hypertension · Fujian Shengdi Pharmaceutical Co., Ltd. · Phase 2
2026-08-28
Primary completion pushed: 2026-07 → 2028-07
Completion pushed: 2026-08 → 2028-08
NCT02425566 Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension · Vanderbilt University · Phase 1
2026-08-15
Primary completion pushed: 2025-03-31 → 2025-10-31
Sponsor changed: Novartis → Novartis Pharmaceuticals
Trial completed
Completion pushed: 2025-03-31 → 2025-10-31
NCT06604897 Effectiveness of Entresto (Sacubitril/Valsartan) in Japanese Patients With Hypertension · Novartis Pharmaceuticals
2026-08-11
Primary completion pushed: 2026-06-18 → 2027-03-31
Completion pushed: 2029-03-20 → 2029-12-31
NCT06526858 Early Feasibility Study of "HyperQureTM RDN System", Laparoscopic Renal Denervation… · DeepQure Inc.
2026-08-11
Primary completion pushed: 2025-11-01 → 2026-07-30
Trial completed
Completion pushed: 2025-11-01 → 2026-07-30
NCT06833060 Transscleral Selective Laser Trabeculoplasty Project · Lumibird Medical (Quantel Medical, Ellex Medical, Optotek)
2026-08-26
Primary completion pushed: 2026-06-30 → 2026-09-30
NCT04626245 Mindfulness & Mechanisms Study · Lifespan
2026-08-26
Primary completion pushed: 2026-06-30 → 2026-12-31
Completion pushed: 2026-12-31 → 2027-07-31
NCT06804122 Exercise-based Rehabilitation in Patients With Pulmonary Arterial Hypertension · Tampere Heart Hospital
2026-08-26
Primary completion pushed: 2031-06-30 → 2032-06-30
Completion pushed: 2031-06-30 → 2032-06-30
NCT05992415 Know Your Pressures NYC · Columbia University
2026-08-22
Primary completion pushed: 2026-06 → 2028-06
Completion pushed: 2026-06 → 2028-06
NCT06432582 hepatomiR cACLD Study · Karl Landsteiner University of Health Sciences
2026-08-22
Primary completion pushed: 2026-06-01 → 2027-06-01
Trial status changed: Enrolling by Invitation → Recruiting
NCT07310849 Digital Care for Holistic Health in Older Adults With Diabetes and Multimorbidity · Chang Gung University of Science and Technology
2026-08-21
Primary completion pushed: 2026-04 → 2026-12
Completion pushed: 2026-04 → 2026-12
NCT05903950 Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce… · Weill Cornell Medical College in Qatar
2026-08-21
Primary completion pushed: 2025-12 → 2026-07-27
Trial completed
NCT06553820 The Effect of MediYoga on Sleep Quality, Blood Pressure, and Quality of Life in Older… · Herlev and Gentofte Hospital
2026-08-21
Primary completion pushed: 2025-12-01 → 2026-09-01
Enrollment closed, study ongoing
Completion pushed: 2026-05-01 → 2026-09-01
NCT05918120 Screening Using Portable Electronic Recorders for Sleep Apnea in Hypertensive At-Risk… · Sunnybrook Health Sciences Centre
2026-08-20
Primary completion pushed: 2026-06 → 2026-11
Completion pushed: 2026-06 → 2026-12
NCT06891911 Groceries for Residents of Southeastern USA to Stop Hypertension · Beth Israel Deaconess Medical Center
2026-08-20
Primary completion pushed: 2027-08-31 → 2027-12-31
NCT05545501 Ketone Ester and Salt (KEAS) in Young Adults · Indiana University
2026-08-20
Primary completion pushed: 2027-08-31 → 2027-12-31
NCT06868719 Ketone Ester And Salt (KEAS) in Older Adults · Indiana University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07789535 Sleep and Arterial Function in Hypertensive Patients With Poor Sleep Quality Unidade Local de Saúde do Alto Ave, EPE new
2026-08-26 NCT07787936 GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry Miedziowe Centrum Zdrowia SA new
2026-08-24 NCT07783061 Reducing Cardiovascular Risks: The Role of Alcohol Use The University of Texas at Arlington new
2026-08-24 NCT07782554 EUS-Guided Portal Pressure Gradient Measurement in Prehepatic Portal Hypertension Second Affiliated Hospital, Zhejiang University, School of Medicine new
2026-08-21 NCT07780500 REFOCUS-HTN US-WEST: A Data Infrastructure to Characterize Individuals With Hypertension Kaiser Permanente new
2026-08-20 NCT07776834 Generative AI-Supported Personalized Education Compared With Printed Material for Adults… Akdeniz University new
2026-08-19 NCT07773272 Cardiovascular-kidney-metabolic (CKM)-Guided Therapy for Patients After Acute Coronary… Zuyderland Medisch Centrum new
2026-08-18 NCT07771504 Health Coaching Added to Standard Therapy for Hypertension: Blood Pressure and Quality of… Indonesia University new
2026-08-18 NCT07770958 Circadian Disruption And Cardiovascular Risk In Young Adults With Hypertension Medical University of Sofia new
2026-08-17 NCT07768644 Nailfold Capillaroscopy in PH University of Glasgow new

Active trials by phase

Early Phase 1
17
Phase 1
54
Phase 1/2
29
Phase 2
81
Phase 2/3
8
Phase 3
85
Phase 4
79
Not charted: 1,186 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,539

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT04715568 Secondhand Tobacco Smoke and Cardiovascular Disease University of California, San Francisco Recruiting 2026-08-19
NCT07322133 Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) University of California, Davis Recruiting 2026-08-18
NCT07713914 Randomized Study of Triple Therapy vs Sildenafil Dose Optimization in Pulmonary Arterial… University of Sao Paulo General Hospital Recruiting 2026-07-30
NCT07140484 Sotatercept in Pulmonary Arterial Hypertension University of Alberta Recruiting 2026-07-09
NCT04401982 Measuring the Effects of Netarsudil, Latanoprost, and Combination Therapy on Episcleral… University of Maryland, Baltimore Recruiting 2026-07-02
NCT07588152 Imaging the Effects of Netarsudil (Rhopressa) on the Trabecular Meshwork in Glaucoma and… Indiana University Recruiting 2026-06-11
NCT06915792 PEACE Trial: Postpartum Evaluation of Antihypertensive Cessation and Efficacy University of California, Los Angeles Recruiting 2026-06-05
NCT06281665 Treatment With Aspirin After Preeclampsia: TAP Trial Malamo Countouris Recruiting 2026-06-04
NCT07607275 Effect of the Traditional Chinese Medicine Yufeng Ningxin in Patients With Hypertension Beijing Anzhen Hospital Recruiting 2026-06-02
NCT07617376 Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions Wroclaw Medical University Recruiting 2026-06-01
NCT06468202 Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy… Ohio State University Recruiting 2026-05-04
NCT07325240 24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular… Mayo Clinic Recruiting 2026-05-01
NCT07521332 Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis Asian Institute Of Medical Sciences Recruiting 2026-04-09
NCT05593055 Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in… Brigham and Women's Hospital Recruiting 2026-04-06
NCT07147114 Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of… Gachon University Gil Medical Center Recruiting 2026-04-03
NCT04454203 Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter… Duke University Recruiting 2026-03-23
NCT06246396 Antihypertensive Mechanisms of Minocycline in Resistant Hypertension University of Florida Recruiting 2026-03-06
NCT06055452 Effects of SGLT2 Inhibitors in Pre-heart Failure Populations With Hypertension China National Center for Cardiovascular Diseases Recruiting 2026-03-05
NCT07217678 Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive… University of Miami Recruiting 2026-03-05
NCT06785116 A Randomized, Placebo-controlled Trial of DAPAgliflozin (DAPA) for Cardiovascular Risk… University of Michigan Recruiting 2026-03-04
NCT07359599 The Impact of IV Iron on Exercise Capacity and Quality of Life in Pulmonary Hypertension Ziekenhuis Oost-Limburg Recruiting 2026-01-30
NCT07361679 LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention Alexandra Hospital, Athens, Greece Recruiting 2026-01-23
NCT06132477 Impact GLP-1 Agonists Following Bariatric University of Missouri-Columbia Recruiting 2026-01-22
NCT06848946 Safety and Efficacy of iDose® TR With Cataract Surgery vs. Cataract Surgery Alone Glaukos Corporation Recruiting 2026-01-21
NCT07356778 A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired… Kazuya Hosokawa Recruiting 2026-01-21
See all 1,539 active Hypertension trials with filters →

Top sponsors by active trials in this area

University of Alabama at Birmingham (22) · Vanderbilt University Medical Center (18) · Assistance Publique - Hôpitaux de Paris (15) · Mayo Clinic (15) · Assiut University (13) · Duke University (13) · Johns Hopkins University (13) · China National Center for Cardiovascular Diseases (11) · University of Sao Paulo General Hospital (11) · Brigham and Women's Hospital (9)

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