Clinical Trial

Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension

Active, Not Recruiting Phase 1
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Record status
This record was last updated August 21, 2025 (before its estimated July 2026 completion). Its status may not reflect the trial's current state.
Summary
The purpose of this study is to better understand the role of the abdominal veins (splanchnic capacitance) and the sympathetic nervous system in human hypertension. The investigators will test the hypothesis that constriction of abdominal veins due to sympathetic activation contributes to human hypertension. Splanchnic capacitance will be assessed in normotensive and hypertensive subjects at baseline and during acute blockade of the autonomic nervous system.
Protocol Amendment History 15 amendments
This ClinicalTrials.gov record has been amended 15 times since 2015-04-23; most recent amendment 2025-08-15.
Status change: Recruiting → Active, Not Recruiting 2023-08-30
Status change: Suspended → Recruiting 2020-09-15
Status change: Recruiting → Suspended 2020-04-08
Trial Details
NCT Number NCT02425566
Lead Sponsor Vanderbilt University
Conditions Hypertension
Enrollment 12 participants
Start Date 2015-04
Primary Completion 2026-07 (estimated)
Study Completion 2026-08 (estimated)
Updated on ClinicalTrials.gov 2025-08-21