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24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients

StatusRecruiting
PhasePhase 4
Started2025-11-21
View on ClinicalTrials.gov ↗

Amendment history

2026-04-27
Study Status, Arms and Interventions v2
InterventionsLatanoprost 0.005% Ophthalmic Solution (Drug), Netarsudil 0.01%/latanoprost 0.005% ophthalmic solution (Drug)→Latanoprost 0.005% Ophthalmic Solution (Drug), Netarsudil 0.02%/latanoprost 0.005% fixed dose combination ophthalmic solution (Drug)
2026-03-19
Active, Not Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusActive, Not Recruiting→Recruiting
Study sitesdetails revised at 1 of 1 site
2026-01-06
Original filing
Mayo Clinic
1,015 trials monitored
See 115 trials at risk
The purpose of this study is to evaluate the effect on 24-hour IOP reduction of netarsudil-latanoprost fixed combination in one eye compared to latanoprost alone in the contralateral eye, dosed daily, 1 drop at night (QD, PM) in adult subjects, at least 18 years of age, with open angle glaucoma (OAG) or ocular hypertension (OHT).
Trial Details
NCT Number NCT07325240
Lead Sponsor Mayo Clinic
Collaborators: Alcon Research
Conditions Open Angle Glaucoma, Ocular Hypertension
Enrollment 30 participants
Start Date 2025-11-21
Primary Completion 2027-07 (estimated)
Study Completion 2027-10 (estimated)
Updated on ClinicalTrials.gov 2026-05-01