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Antihypertensive Mechanisms of Minocycline in Resistant Hypertension

StatusRecruiting
PhasePhase 4
Started2025-01-08
View on ClinicalTrials.gov ↗

Amendment history

2026-03-05
Study Status v7
Re-verified, no change to tracked fields
2026-01-13
Study Status, Eligibility, Contacts/Locations v6
Study sites1 entry, revised
UF HealthClinical CardiologyResearch Center (UF CRC) - Heart & Vascular HospitalCTSI
2025-07-25
Study Status, Study Description, Eligibility v5
Eligibility criteria-188 characters
Inclusion Criteria: Age ≥18 years Self-identify as White or African American Uncontrolled TRH, defined as uncontrolled blood pressure (me [...] ≥80 mm Hg) while being adherent to a stable (no changes in ≥3014 days prior) antihypertensive regimen of 3 or more drugs, including an adequately dosed thiazidediuretic or thiazide-likeunable to tolerate a diuretic (hydrochlorothiazide ≥25 mg/day or equivalent). The participant agrees to have all study procedures perform [...] g the MDRD equation Known secondary hypertension History of antihypertensivehypertensive crisis, defined as any in-patient hospitalizations f [...] [...]
Study description-109 characters
One hundred twenty patients (targeting 60 White patients and 60 Black or African American [AA] patients) with treatment-resistant hypertension will be enrolled. A total of 34 patients (17 from each treatment arm, with similar race distribution), who are participants in the main study, will also be enro [...]
2025-01-08
Study Status v4
Start dateestimated 2024-12-20→confirmed 2025-01-08
2024-12-09
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v3
Trial statusNot Yet Recruiting→Recruiting
Start date2024-10-01→2024-12-20
Study sites1 entry, revised
UF Health CardiovascularCardiology Clinic- Heart & Vascular Hospital
Show 2 earlier versions
2024-07-22
Study Status v2
Start date2024-04-01→2024-10-01
2024-02-26
Study Identification, Study Status, Outcome Measures v1
Re-verified, no change to tracked fields
2024-01-30
Original filing
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension. The main questions it aims to answer are: * To what extent does minocycline lower blood pressure? * Are such blood pressure effects mediated through changes in gut microbiota, gut leakiness, systemic inflammation, neuroinflammation, or some combination of these? Participants will be randomly assigned to treatment with minocycline or placebo, treated daily for 3 months, to evaluate these questions.
Trial Details
NCT Number NCT06246396
Lead Sponsor University of Florida
Collaborators: Emory University, National Heart, Lung, and Blood Institute (NHLBI)
Conditions Hypertension, Resistant to Conventional Therapy
Enrollment 120 participants
Start Date 2025-01-08
Primary Completion 2028-07 (estimated)
Study Completion 2028-07 (estimated)
Updated on ClinicalTrials.gov 2026-03-06