Sponsor pipeline

National Institute of Mental Health (NIMH) clinical trial pipeline

Get alerts when National Institute of Mental Health (NIMH)'s trials change
Data updated daily from ClinicalTrials.gov, last refresh 2026-10-16

What changed in the last 30 days

7 trials changed in the last 30 days: 0 stopped, 3 with notable changes, 4 with minor changes only.

  1. Notable

    Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)

    Recruitment opened

    Also in this update: Start date changed from estimate of Sep 23, 2026 to Sep 17, 2026; and 1 more change in the last 30 days

    National Institute of Mental Health (NIMH)Not specified NCT07566468 Registry history of NCT07566468 on ClinicalTrials.gov (opens the registry)

    Updated

Show 4 trials with minor changes only
  1. Minor

    Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial

    Primary completion pushed from Jun 1, 2028 to Sep 1, 2028

    Also in this update: Study completion pushed from Jun 1, 2028 to Nov 1, 2028; Interventions modified

    National Institute of Mental Health (NIMH)Phase 1/2 NCT05608434 Registry history of NCT05608434 on ClinicalTrials.gov (opens the registry)

    Updated

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-10-02 NCT07853781 First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE4D Imaging in Healthy Volunteers Phase 1 Recruiting

Active trials by phase

Early Phase 1
1
Phase 1
13
Phase 1/2
1
Phase 2
4
Not charted: 28 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 47

NCT IDTitleConditionStatusUpdated
Phase 2
NCT02543983 Neurobiology of Suicide Healthy Volunteers Recruiting 2026-10-13
NCT06595953 Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety Psychiatric Disorders Recruiting 2026-10-13
NCT06511908 Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic… Suicide Recruiting 2026-10-05
NCT00018057 Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders Anxiety Disorders Recruiting 2026-09-22
Phase 1/2
NCT05608434 Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets… Attention Deficit Hyperactivity Disorder Recruiting 2026-10-08
Phase 1
NCT07169630 PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or… Alzheimer s Disease Recruiting 2026-10-15
NCT03065335 Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and… Healthy Volunteer Recruiting 2026-10-13
NCT07853781 First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE4D Imaging in Healthy Volunteers Healthy Recruiting 2026-10-09
NCT05703685 [18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET Depression Recruiting 2026-10-01
NCT07625345 Evaluation of [11C]ZTP-1 to Image PDE4B Healthy Recruiting 2026-10-01
NCT07686393 PET Imaging of Noradrenergic Transmission in the Brain Healthy Recruiting 2026-09-29
NCT04396873 PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease Parkinson's Disease Recruiting 2026-09-18
NCT06795581 PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder Alcohol Use Disorder Recruiting 2026-09-18
NCT03973268 Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput… Depression Recruiting 2026-09-10
NCT04582916 PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD) Depression Recruiting 2026-08-18
NCT06874205 Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers Healthy Recruiting 2026-08-18
NCT06920628 PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of… Long COVID Recruiting 2026-08-18
NCT07027839 Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B) Alcohol Use Disorder Recruiting 2026-08-17
Early Phase 1
NCT06484088 Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers Irritability Recruiting 2026-10-06
Not applicable
NCT00109174 MRS Measurement of Glutamate and GABA Metabolism in Brain Normal Physiology Recruiting 2026-10-13
NCT01266577 Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging… Brain Mapping Recruiting 2026-10-08
NCT04950309 Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG)… Normal Physiology Recruiting 2026-10-05
NCT05666726 State-dependent Interoception, Value-based Decision-making, and Introspection Stress Recruiting 2026-10-02
NCT04798274 Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder Autism Spectrum Disorder Recruiting 2026-04-09
NCT05172271 Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD) Major Depressive Disorder Active, Not Recruiting 2026-08-12

Disease areas by active trials, top 10 of 11

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