Disease landscape

ALS clinical trials

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309 active trials 190 recruiting 18 Phase 3 208 sponsors 40 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-16

What changed in the last 30 days showing 38 of 40 changes on 20 trials

2026-09-16
Trial terminated
Trial terminated: The study was terminated following review of interim data indicating that continuation was unlikely to demonstrate a cl...
NCT06441682 A Safety and Efficacy Study of ARGX-119 in Adult Patients With Amyotrophic Lateral… · argenx · Phase 2
2026-09-12
Primary completion pushed: 2025-12-31 → 2027-12-31
Completion pushed: 2026-06-30 → 2028-06-30
NCT03651349 To Determine the Maximum Tolerated Dose (MTD) of HK-001 in Healthy Volunteers · Everfront Biotech Co., Ltd. · Phase 1
2026-09-11
Primary completion pushed: 2026-06 → 2026-10
Completion pushed: 2026-11 → 2027-02
NCT06649955 Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study · PathMaker Neurosystems Inc.
2026-09-11
Primary completion pushed: 2026-06 → 2029-01-30
Completion pushed: 2026-06 → 2029-06
NCT06450418 Digital App for Speech & Health Monitoring · University of Edinburgh
2026-09-09
Primary completion pushed: 2026-07-01 → 2027-10-01
Completion pushed: 2026-08-01 → 2027-10-01
NCT07589764 Pilot Trial Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels in People With ALS · Duke University · Phase 1
2026-08-18
Primary completion pushed: 2027-05-01 → 2027-08-01
Recruitment opened
Completion pushed: 2027-05-31 → 2027-10-31
NCT07224269 Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis · University of Iowa · Early Phase 1
2026-08-29
Primary completion pushed: 2026-08 → 2027-02
Enrollment closed, study ongoing
Completion pushed: 2026-08 → 2027-02
NCT06856850 Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond… · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
2026-08-22
Primary completion pushed: 2026-08-31 → 2028-12-31
Completion pushed: 2026-08-31 → 2030-12-31
NCT03567213 Investigation on the Cortical Communication (CortiCom) System · Johns Hopkins University
2026-09-03
Enrollment closed, study ongoing
Primary completion 2026-07-01, at least 182 days after the final estimate of 2025-12
Final enrollment: 21 participants (planned 60)
Completion pushed: 2025-12 → 2026-12
NCT04244630 Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial · Dallas VA Medical Center · Phase 2
2026-09-11
Trial status changed: Unknown → Completed
Primary completion confirmed: February 2025 (last estimated October 2024)
NCT03766321 Fecal Microbiota Transplantation Effect on Amyotrophic Lateral Sclerosis Patients · Azienda Ospedaliero-Universitaria di Modena
2026-09-10
Enrollment closed, study ongoing
Completion pushed: 2026-09-30 → 2027-02-28
NCT06551649 Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration and Neuroinflammation · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
2026-09-16
Primary completion pushed: 2027-05-01 → 2027-07-01
Start date pushed: 2026-08-01 → 2026-10-01
Completion pushed: 2027-05-01 → 2027-07-01
NCT07794072 Digital Patient Engagement in Technology-Supported Neurorehabilitation · Catholic University, Italy
2026-09-04
Trial completed
Final enrollment: 8 participants (planned 30)
NCT06363357 The Effect of a Muscle-mimicking, Fabric-type Shoulder Orthosis on Functional Movements… · Seoul National University Hospital
2026-09-02
Trial sites expanded: 17 → 49 locations
NCT07023835 Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral… · Zydus Therapeutics Inc. · Phase 2
2026-09-09
Completion pushed: 2026-09 → 2028-09
NCT05035823 COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People… · Synchron Medical, Inc.
2026-08-21
Completion pushed: 2026-06-30 → 2027-08-31
NCT04220021 Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD · University of Florida · Phase 2
2026-09-06
Trial status changed: Active, Not Recruiting → Unknown
NCT05021536 Phase III Trial of AMX0035 for Amyotrophic Lateral Sclerosis Treatment · Amylyx Pharmaceuticals Inc. · Phase 3
2026-09-06
Trial status changed: Not Yet Recruiting → Unknown
NCT06315608 MRG-001 in Patients With Amyotrophic Lateral Sclerosis · MedRegen LLC · Phase 2
2026-09-06
Trial status changed: Recruiting → Unknown
NCT06539169 FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases · xCures
2026-09-06
Trial status changed: Recruiting → Unknown
NCT06566651 Emotion Processing Among Patients With ALS · University of Aarhus

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-14 NCT07818772 7T Imaging Pilot-study in Patients With Motor Neuron Disease to Find Non-Invasive Disease… NHS Greater Glasgow and Clyde new
2026-08-31 NCT07794072 Digital Patient Engagement in Technology-Supported Neurorehabilitation Catholic University, Italy new
2026-07-31 NCT07739134 Multimodal Tracking of Therapy Activity and Effort During Rehabilitation ETH Zurich new
2026-07-13 NCT07698496 Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for… University Hospital, Grenoble new
2026-07-07 NCT07688239 The BANYAN Trial, an ALS MyMatch Trial Evaluating Safety, Biomarker Activity, and… Tiziana Life Sciences LTD new Phase 2
2026-07-02 NCT07680361 Study of Home Use of the Jaco Robotic Manipulation Device by Individuals With Tetraplegia Association APPROCHE new
2026-06-29 NCT07674667 FUNCtion ALS: Aiming to Restore UNC13A Function in People Living With ALS Trace Neuroscience, Inc. new Phase 1/2
2026-06-22 NCT07660614 A Study of LTX-002 in Adult Participants With Amyotrophic Lateral Sclerosis Leal Therapeutics, Inc new Phase 1/2
2026-06-18 NCT07656714 HFCWO Vest Plus Mechanical Cough Assist Versus Cough Assist Alone on Respiratory… Hospital Universitario Virgen Macarena new

Active trials by phase

Early Phase 1
11
Phase 1
28
Phase 1/2
24
Phase 2
22
Phase 2/3
12
Phase 3
6
Phase 4
2
Not charted: 204 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 309

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05923905 Clinical Study to Evaluate the Efficacy and Safety of FB1006 in the Treatment of ALS… Peking University Third Hospital Recruiting 2023-11-22
NCT07223723 A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese… Biogen Active, Not Recruiting 2026-08-13
Phase 3
NCT07322003 Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS Prilenia Recruiting 2026-09-15
NCT03127267 Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients AB Science Recruiting 2025-09-12
NCT04768972 FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics… Ionis Pharmaceuticals, Inc. Active, Not Recruiting 2026-07-21
NCT04856982 A Study of BIIB067 (Tofersen) Initiated in Clinically Presymptomatic Adults With a… Biogen Active, Not Recruiting 2026-03-30
NCT07174492 Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment… AB Science Not Yet Recruiting 2025-10-03
NCT06973629 Efficacy and Safety of MSC-NTF (NurOwn) in Participants With Early Symptomatic ALS and… Brainstorm-Cell Therapeutics Not Yet Recruiting 2025-05-22
Phase 2/3
NCT07161999 Study of COYA 302 for the Treatment of ALS Coya Therapeutics Recruiting 2026-08-06
NCT06719947 HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial Universidade Federal do Rio Grande do Norte Recruiting 2026-07-20
NCT04302870 Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial University of Edinburgh Recruiting 2026-03-04
NCT06126315 Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS Mario Negri Institute for Pharmacological Research Recruiting 2025-09-25
NCT04220190 RAPA-501 Therapy for ALS Rapa Therapeutics LLC Recruiting 2025-06-18
NCT07325591 Efficacy and Safety of Tazbentetol in ALS Participants Spinogenix Not Yet Recruiting 2026-09-10
NCT04297683 HEALEY ALS Platform Trial - Master Protocol Merit E. Cudkowicz, MD Active, Not Recruiting 2026-07-21
NCT07410806 HEALEY ALS Platform Trial - Regimen I NUZ-001 Merit E. Cudkowicz, MD Active, Not Recruiting 2026-07-20
NCT04057898 Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6… MediciNova Active, Not Recruiting 2026-03-06
NCT07321860 This Study Evaluates the Safety, Target Engagement, and Preliminary Efficacy of… Gipfel Life Sciences GmbH Not Yet Recruiting 2026-01-07
NCT07082192 A Study to Evaluate the Efficacy and Safety of Different Doses of CB03-154 in Adult… Shanghai Zhimeng Biopharma, Inc. Not Yet Recruiting 2025-07-24
NCT06391645 Nerve Growth Factor Encapsulated With 2-methacryloyloxyethyl Phosphorylcholine… Beijing Tiantan Hospital Not Yet Recruiting 2024-04-30
Phase 2
NCT07023835 Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral… Zydus Therapeutics Inc. Recruiting 2026-09-01
NCT07142291 PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS PhenoNet, Inc. Recruiting 2026-07-23
NCT07071935 A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS) University of Pennsylvania Recruiting 2026-06-26
NCT07294144 Tofersen in Non-SOD1 ALS Washington University School of Medicine Recruiting 2026-06-25
NCT05407324 Dazucorilant in Patients With Amyotrophic Lateral Sclerosis Corcept Therapeutics Recruiting 2026-06-16
See all 309 active ALS trials with filters →

Top sponsors by active trials in this area

University of Miami (7) · n-Lorem Foundation (6) · National Institute of Neurological Disorders and Stroke (NINDS) (6) · Neuralink Corp (6) · Nova Southeastern University (6) · Istituto Auxologico Italiano (5) · Peking University Third Hospital (5) · Assistance Publique - Hôpitaux de Paris (4) · Beijing Tiantan Hospital (4) · Haukeland University Hospital (4)

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