Also listed under Motor Neuron Disease, TDP-43 Proteinopathies
ClinicalTrials.gov term: Amyotrophic Lateral Sclerosis
ALS clinical trials
Data updated daily from ClinicalTrials.gov, last refresh 2026-11-06
What changed in the last 30 days
24 trials changed in the last 30 days: 0 stopped, 14 with notable changes, 10 with minor changes only.
- Notable: Alter-Ego · Assistive Robotic Device Primary endpoint(s) modified
- Minor: INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study Enrollment closed, study ongoing
- Minor: LY4256984 · Sporadic Amyotrophic Lateral Sclerosis Enrollment increased: 32 → 36 participants
- Notable: ROAR HMB · Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels · ALS Start date pushed from Oct 1, 2026 to Dec 1, 2026
- Minor: Structurally Suitable Neck Exoskeleton · Amyotrophic Lateral Sclerosis Trial completed
- Minor: TBCS · Advances in Telephone-based Cognitive Screening Procedures Changed Registry marked status Unknown (sponsor has not verified the record since Mar 2024); last known: Recruiting
- Notable: BANYAN · BANYAN Trial, an ALS MyMatch Trial Evaluating Safety, Biomarker Activity, and Microglial Activation of Nasal Foralumab Enrolling by invitation only
- Notable: Tregs in ALS · T-regulatory Cells in ALS Results posted: Oct 28, 2026
- Minor: Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis Start date pushed from Oct 2026 to Nov 2026
- Notable: BG-Tablet-01 · BrainGate2 Neural Interface System · Tetraplegia Primary completion pushed from Jul 30, 2026 to Jul 30, 2027
- Minor: PREVENT ALL ALS Study Enrollment closed, study ongoing
- Notable: W-MoSCA · Rare Disease Registry Database for Movement Disorders in Southern Anhui Province Enrollment reopened
- Notable: REGALS · Regulatory T Cells for Amyotrophic Lateral Sclerosis Primary completion pushed from May 2026 to May 2027
- Notable: ATLAS · Tofersen (BIIB067) Can Delay ALS Symptoms and About Its Safety · a SOD1 Gene Mutation Who Have Not Yet Developed ALS Symptoms Primary endpoint(s) modified
- Notable: HORIZON · BIIB147 and Its Effects · Amyotrophic Lateral Sclerosis (ALS) Recruitment opened
- Minor: Registry Study of Assistive Devices, Medicines and Healthcare Measures in ALS, SMA and Other Neurological Diseases Trial completed
- Notable: Brain-Computer Interface Communication Device · ALS Recruitment opened
- Notable: ALS · Is to Assess the Safety and Tolerability of VTx-002 · ALS Enrollment increased: 12 → 36 participants
- Minor: ALSTARS · COYA 302 · ALS Enrollment closed, study ongoing
- Minor: Use of Dalfampridine in Primary Lateral Sclerosis Trial status changed: Unknown → Completed
- Stopped: terminated, suspended or withdrawn
- Notable: the plan changed
- Minor: routine updates
New sponsor entrants, last 90 days sponsors with their first trial in this area
| First posted | Trial | Sponsor | Phase |
|---|---|---|---|
| 2026-10-30 | NCT07906665 A Study of Single Ascending Doses of NI112 in Adults With Amyotrophic Lateral Sclerosis… | Sachi Bioworks Inc. new | Phase 1 |
| 2026-10-15 | NCT07875972 Safety, Tolerability, and Pharmacodynamic Exploration of Orelabrutinib in Patients With… | Liu Qing new | Phase 1 |
| 2026-10-08 | NCT07865260 PhiCube for Bilateral Upper Limb Neuromotor and Cognitive Rehabilitation in Adults | Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato new | |
| 2026-09-24 | NCT07838389 Evaluation of Donor-Derived B Cell Infusions in Patients With Amyotrophic Lateral… | Mark Poznansky new | Phase 1 |
| 2026-09-24 | NCT07838883 Rare Disease Registry Database for Movement Disorders in Southern Anhui Province | First Affiliated Hospital of Wannan Medical College new | |
| 2026-09-22 | NCT07834450 Efficacy and Safety of Cyclophosphamide in Amyotrophic Lateral Sclerosis | Huashan Hospital new | Phase 2 |
| 2026-09-22 | NCT07833618 A Phase II Study of ALT001 in Patients With Amyotrophic Lateral Sclerosis (ALS) | Darwin Origin (Hubei) Biopharmaceutical Co., Ltd. new | Phase 2 |
| 2026-09-14 | NCT07818772 7T Imaging Pilot-study in Patients With Motor Neuron Disease to Find Non-Invasive Disease… | NHS Greater Glasgow and Clyde new | |
| 2026-08-31 | NCT07794072 Digital Patient Engagement in Technology-Supported Neurorehabilitation | Catholic University, Italy new |
Active trials by phase
| Early Phase 1 | 11 | |
| Phase 1 | 31 | |
| Phase 1/2 | 25 | |
| Phase 2 | 24 | |
| Phase 2/3 | 12 | |
| Phase 3 | 6 | |
| Phase 4 | 2 |
Not charted: 208 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).
Top sponsors by active trials in this area
University of Miami (7) · n-Lorem Foundation (6) · National Institute of Neurological Disorders and Stroke (NINDS) (6) · Neuralink Corp (6) · Nova Southeastern University (6) · Johns Hopkins University (5) · Leigh R. Hochberg, MD, PhD. (5) · Peking University Third Hospital (5) · Assistance Publique - Hôpitaux de Paris (4) · Beijing Tiantan Hospital (4)
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