Disease landscape

Bipolar Disorder clinical trials

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277 active trials 178 recruiting 23 Phase 3 175 sponsors 30 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-16

What changed in the last 30 days

2026-09-16
Primary completion pushed: 2026-05-31 → 2029-05-31
Completion pushed: 2027-05-31 → 2029-05-31
NCT05296356 OSU6162 in Bipolar Depression (OBID) · Göteborg University · Phase 2
2026-09-05
Primary completion pushed: 2026-06-30 → 2026-12-30
Recruitment opened
Completion pushed: 2026-12 → 2027-06
NCT07239778 The PEDAL Intervention - Reducing Affective Lability in Bipolar Disorder · Oslo University Hospital · Phase 2
2026-08-28
Primary completion pushed: 2025-02 → 2030-09
Completion pushed: 2025-02 → 2030-12
NCT04569448 Brexpiprazole Treatment for Bipolar I Depression · Douglas Mental Health University Institute · Phase 3
2026-08-28
Primary completion pushed: 2025-06 → 2025-10-27
Enrollment reduced: 50 → 31 participants
Trial completed
Completion moved earlier: 2026-08 → 2025-10-27
NCT00590265 Light-Therapy in the Treatment of the Acute Phase of the Bipolar Type II Depression · Douglas Mental Health University Institute
2026-08-19
Primary completion pushed: 2026-07 → 2026-12
Completion pushed: 2026-07 → 2026-12
NCT05878730 Melatonin and Response to Lithium · Assistance Publique - Hôpitaux de Paris
2026-08-28
Primary endpoint(s) modified
NCT07783633 Identifying Biomarkers of Response to Digital Interventions for Mood Disorders · Centre for Addiction and Mental Health
2026-09-16
Phase changed: Phase 3 → Phase 2
Recruitment opened
NCT06943573 Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II Disorder · Lakshmi N Yatham · Phase 2
2026-09-11
Trial completed
NCT00001174 Evaluation of the Genetics of Bipolar Disorder · National Institute of Mental Health (NIMH)
2026-09-12
Recruitment opened
NCT07699445 The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With… · Massachusetts General Hospital · Phase 4
2026-08-20
Recruitment opened
NCT06898879 Enhancing Veteran-Clinical Collaboration in VA PRRCs · VA Office of Research and Development
2026-09-15
Trial sites expanded: 174 → 182 locations
NCT06929273 A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in… · Bristol-Myers Squibb · Phase 3
2026-08-25
Completed without a posted recruiting period
Primary completion pushed: 2026-03-31 → 2026-06-15
NCT07374588 Impact of Medication Education on Adherence and Side Effects · Cumhuriyet University
2026-09-03
Trial sites expanded: 28 → 44 locations
NCT07172516 A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With… · Xenon Pharmaceuticals Inc. · Phase 3
2026-09-03
Trial sites expanded: 15 → 20 locations
NCT07217860 An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE) · Xenon Pharmaceuticals Inc. · Phase 3
2026-08-29
Trial sites expanded: 61 → 64 locations
NCT06229210 Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia… · Intra-Cellular Therapies, Inc. · Phase 3
2026-09-06
Trial status changed: Recruiting → Unknown
NCT03423680 A Study of Abilify® Tablet(Aripiprazole) as an Adjunctive Treatment in the Bipolar… · Korea Otsuka Pharmaceutical Co., Ltd. · Phase 3
2026-09-06
Trial status changed: Not Yet Recruiting → Unknown
NCT06235177 Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological… · The Essence of Integrative Health and Medicine Practice · Early Phase 1
2026-09-06
Trial status changed: Not Yet Recruiting → Unknown
NCT06580535 Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas · Assiut University
2026-09-06
Trial status changed: Not Yet Recruiting → Unknown
NCT06515522 A Biological Signature for the Early Differential Diagnosis of Psychosis · IRCCS San Raffaele
2026-09-06
Trial status changed: Recruiting → Unknown
NCT05178966 Evaluation of Efficiency of One Day Patient/Caregiver Psychoeducation on the Caregiver's… · University Hospital, Montpellier

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-08 NCT07806227 Broadband Near Infrared Spectroscopy to Understand the Role of Brain Cytochrome C Oxidase… Martin Lan new Phase 4
2026-08-25 NCT07785167 Chemokine Receptors on CD8+ T Cells in Patients With Bipolar Disorder University of Catania new
2026-08-06 NCT07750925 Examining Lithium's Mechanism in Bipolar Disorder Northumbria University new
2026-08-04 NCT07745374 Safety and Feasibility of DBS for Bipolar Depression Icahn School of Medicine at Mount Sinai new
2026-07-31 NCT07740694 EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major… Istanbul University - Cerrahpasa new
2026-07-29 NCT07733297 The Effect of Cognitive Behavioral Psychoeducation on Internalized Stigma in Individuals… Eskisehir Osmangazi University new
2026-07-29 NCT07732933 Testing a New Gold Nanoparticle-Based Lithium Delivery Method for Bipolar Disorder in… Fondazione Policlinico Universitario Agostino Gemelli IRCCS new
2026-07-22 NCT07719998 A Psychoeducational Intervention for Reducing Psychological Distress and Caregiver… GIFT University new
2026-07-20 NCT07713849 Transition Care for FEP University of Chicago new
2026-07-06 NCT07684911 Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols… Hospital Center Guillaume Régnier new

Active trials by phase

Early Phase 1
3
Phase 1
4
Phase 1/2
4
Phase 2
23
Phase 2/3
2
Phase 3
21
Phase 4
20
Not charted: 200 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 277

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07699445 The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With… Massachusetts General Hospital Recruiting 2026-09-11
NCT06740890 Exercise and Olanzapine-samidorphan New York State Psychiatric Institute Recruiting 2026-07-13
NCT07266545 RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression… Mayo Clinic Recruiting 2026-06-22
NCT07105111 A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive… Neurocrine Biosciences Recruiting 2026-06-16
NCT04580134 CLOZAPINE Response in Biotype-1 University of Texas Southwestern Medical Center Recruiting 2026-05-11
NCT06184581 Lithium Versus Lamotrigine in Bipolar Disorder, Type II University Hospital Bispebjerg and Frederiksberg Recruiting 2026-03-20
NCT07213466 Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder Mayo Clinic Recruiting 2026-03-11
NCT05913947 Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9) Aalborg University Hospital Recruiting 2026-01-21
NCT07026461 Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided… Region Örebro County Recruiting 2025-12-16
NCT04057378 Optimal Electrical Stimulus During Electroconvulsive Therapy Region Örebro County Recruiting 2025-06-22
NCT05648591 Safety and Tolerability of Open-Labeled Iloperidone in Adolescents Vanda Pharmaceuticals Recruiting 2025-03-04
NCT06417437 Non-invasive BCI and Application Verification for Depressed People Shanghai Mental Health Center Recruiting 2024-05-16
NCT07676669 This Study Aims to Compare the Efficacy and Safety of Lumateperone and Cariprazine in… Watim Medical & Dental College Not Yet Recruiting 2026-09-09
NCT07806227 Broadband Near Infrared Spectroscopy to Understand the Role of Brain Cytochrome C Oxidase… Martin Lan Not Yet Recruiting 2026-09-08
NCT07680153 Neuromodulation of Mood Switch Circuitry in Bipolar Disorder Weill Medical College of Cornell University Not Yet Recruiting 2026-07-02
NCT07665073 Risperidone vs Cariprazine in Acute Mania Pakistan Institute of Medical Sciences Not Yet Recruiting 2026-06-24
NCT07047651 Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. Dr. Stavroula Rakitzi Active, Not Recruiting 2026-05-01
NCT06433635 Sequential Multiple Assignment Randomized Trial for Bipolar Depression Massachusetts General Hospital Active, Not Recruiting 2025-12-16
NCT05044611 AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar… Assistance Publique - Hôpitaux de Paris Active, Not Recruiting 2025-05-09
NCT06662526 Lithium for Prevention of Cognitive Declining in Mood Illnesses University of Chile Not Yet Recruiting 2024-10-30
Phase 3
NCT06929273 A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in… Bristol-Myers Squibb Recruiting 2026-09-14
NCT06951698 A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes… Bristol-Myers Squibb Recruiting 2026-09-04
NCT06951711 A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes… Bristol-Myers Squibb Recruiting 2026-09-04
NCT07172516 A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With… Xenon Pharmaceuticals Inc. Recruiting 2026-09-02
NCT06229210 Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia… Intra-Cellular Therapies, Inc. Recruiting 2026-08-28
See all 277 active Bipolar Disorder trials with filters →

Top sponsors by active trials in this area

Massachusetts General Hospital (9) · Mclean Hospital (7) · VA Office of Research and Development (7) · Centre for Addiction and Mental Health (6) · Mayo Clinic (6) · Shanghai Mental Health Center (6) · Centre Hospitalier St Anne (5) · First Affiliated Hospital of Zhejiang University (5) · University of Sao Paulo (5) · AbbVie (4)

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