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SPERLICNCT07785167

Chemokine Receptors on CD8+ T Cells in Patients With Bipolar Disorder

StatusNot Yet Recruiting
PhaseNot specified
Primary completion (estimated)
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Record History

All 1 version: 1 with changes below.

  1. Study First Submitted

Endpoints

Primary

Relative mRNA Expression of CCR5 in CD8+ T Lymphocytes
Timeframe: At baseline (single study visit)
Relative mRNA Expression of CXCR3 in CD8+ T Lymphocytes
Timeframe: At baseline (single study visit)

Secondary (3)

Relative mRNA Expression of PSGL-1 in CD8+ T Lymphocytes
Relative mRNA Expression of VLA-4 in CD8+ T Lymphocytes
Relative mRNA Expression of LFA-1 in CD8+ T Lymphocytes

Arms and interventions

Bipolar Disorder Group

Participants aged 25-35 years with a diagnosis of Bipolar I or Bipolar II Disorder who are either drug-naive or have been free from psychopharmacological treatment for at least 6 months. Participants will be characterized according to the current mood phase, including depressive and manic/hypomanic episodes.

Healthy Control Group

Healthy volunteers aged 25-35 years without clinical evidence of Bipolar I or Bipolar II Disorder and not receiving psychotropic medications. Eligible controls must have a Hamilton Depression Rating Scale score \<8 and a Mania Rating Scale score \<11.

Other: CD8+ T-Cell Gene Expression Analysis

Sites

1 site in 1 country

  • Psychiatry Unit, Policlinico "G.Rodolico" Hospital, Via Santa Sofia 78Catania, Sicily, Italy