Bipolar Disorder clinical trials
Data updated daily from ClinicalTrials.gov, last refresh 2026-11-05
What changed in the last 30 days
16 trials changed in the last 30 days: 0 stopped, 8 with notable changes, 8 with minor changes only.
- Notable: SEM EDIT-B · Impact of the EDIT-B® Blood Test on the Health Status of Patients Presenting a Major Depressive Episode. Clinical Utility and Medico-Economic Aspects Primary completion pushed from May 2026 to Apr 2028
- Minor: Adjunctive KarXT · Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine Trial sites expanded: 104 → 109 locations
- Notable: Psychophysiological Responses to Six Single-Session Self-Regulation Interventions in a Female · ADHD and Stabilized Bipolar Disorder Primary and study completion pushed from Oct 30, 2026 to Apr 30, 2027
- Minor: LAP-ST vs ECT · Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy Enrollment closed, study ongoing
- Minor: RAP-219 · Bipolar I Disorder Trial completed
- Notable: Stress Management With Real-time Bio-signal Biofeedback Primary completion date changed from estimate of Jun 30, 2025 to Jun 11, 2026
- Notable: B-HAPPI · Pramipexole vs Placebo Treatment in Bipolar Disorder With Anhedonic Depression Recruitment opened
- Minor: Narrative Enhancement and Cognitive Therapy for Self-Stigma in Youth Trial completed
- Notable: Quality of Life, Safety and Compliance of Patients Using Monotherapy or Combinatorial Therapy With Quetiapine · Schizophrenia or Bipolar Affective Disorder Primary endpoint(s) modified
- Notable: ALTO-100 in Bipolar Disorder With Depression (BD-D) Primary completion pushed from Aug 2026 to Sep 2027
- Minor: X-CEED · Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression) Enrollment closed, study ongoing
- Minor: Azetukalner in Bipolar I or II Depression (X-CEED-OLE) Trial status changed: Enrolling by Invitation → Active, Not Recruiting
- Notable: Attentional Biases, Reward Sensitivity, and Cognitive Control · Bipolar Disorder Primary and study completion pushed from Sep 1, 2026 to Apr 1, 2027
- Minor: Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder Trial completed
- Notable: Socio-cognitive and Biological Responses to Maltreatment Recruitment opened
- Minor: Impact of Ketogenic Therapy on Symptom Severity and Metabolic Side Effect Profile · Bipolar Disorder in A Rural Southern Catchment Area Start date pushed from Oct 2026 to Nov 2026
- Stopped: terminated, suspended or withdrawn
- Notable: the plan changed
- Minor: routine updates
New sponsor entrants, last 90 days sponsors with their first trial in this area
| First posted | Trial | Sponsor | Phase |
|---|---|---|---|
| 2026-10-19 | NCT07881016 French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major… | Fondation FondaMental new | |
| 2026-10-16 | NCT07879118 Effect of Occupational Therapy on Psychosocial Parameters and Functioning in Individuals… | Biruni University new | |
| 2026-10-14 | NCT07872878 BAROMETRE : Study on the Prognosis and Course of Individuals With Bipolar Spectrum… | University Hospital, Angers new | |
| 2026-10-05 | NCT07858565 Quality of Life, Safety and Compliance of Patients Using Monotherapy or Combinatorial… | Bosnalijek D.D new | |
| 2026-09-22 | NCT07834112 Body Weight Changes After Switching to Lurasidone for Antipsychotic-induced Weight Gain… | Dong-Wook Kim new | |
| 2026-09-22 | NCT07833267 Cognition and Affective Research in China | Xuanwu Hospital, Beijing new | |
| 2026-08-25 | NCT07785167 Chemokine Receptors on CD8+ T Cells in Patients With Bipolar Disorder | University of Catania new |
Active trials by phase
| Early Phase 1 | 2 | |
| Phase 1 | 4 | |
| Phase 1/2 | 4 | |
| Phase 2 | 23 | |
| Phase 2/3 | 1 | |
| Phase 3 | 20 | |
| Phase 4 | 20 |
Not charted: 223 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).
Top sponsors by active trials in this area
Massachusetts General Hospital (8) · VA Office of Research and Development (8) · Mclean Hospital (7) · Centre Hospitalier St Anne (6) · Mayo Clinic (6) · Centre for Addiction and Mental Health (5) · First Affiliated Hospital of Zhejiang University (5) · Shanghai Mental Health Center (5) · AbbVie (4) · Bristol-Myers Squibb (4)
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Status changes, date slips, and new sponsor entrants: detected daily, delivered to your inbox.