| Detected | Trial | Change |
|---|---|---|
| 2026-06-11 | NCT07342764 Dapagliflozin Versus Metformin for the Management of Antipsychotic-Induced Weight Gain: A… |
Primary endpoint(s) modified |
| 2026-06-11 | NCT07342764 Dapagliflozin Versus Metformin for the Management of Antipsychotic-Induced Weight Gain: A… |
Trial arms changed: 3 -> 2 |
| 2026-06-05 | NCT04545736 Oral Metformin for Treatment of ABCA4 Retinopathy |
overall status: "Recruiting" → "Active Not Recruiting" |
| 2026-06-05 | NCT04545736 Oral Metformin for Treatment of ABCA4 Retinopathy |
date change Primary completion moved earlier: 2028-09-30 -> 2028-02-02 |
| 2026-06-05 | NCT04545736 Oral Metformin for Treatment of ABCA4 Retinopathy |
date change Completion pushed: 2028-09-30 -> 2029-02-02 |
| 2026-06-05 | NCT07603505 Effect of NAE on Polycystic Ovarian Syndrome (PCOS) |
overall status: "Recruiting" → "Active Not Recruiting" |
| 2026-05-29 | NCT07530289 A Clinical Study of Ulonivirine (MK-8507) With Atorvastatin and Metformin in Healthy… |
overall status: "Recruiting" → "Active Not Recruiting" |
| 2026-05-28 | NCT07603505 Effect of NAE on Polycystic Ovarian Syndrome (PCOS) |
Primary endpoint(s) modified |
| 2026-05-19 | NCT07585396 Inositol in Letrozol Resistant PCOS Women |
overall status: "Not Yet Recruiting" → "Completed" |
| 2026-05-19 | NCT07585396 Inositol in Letrozol Resistant PCOS Women |
date change Primary completion moved earlier: 2027-05-14 -> 2026-05-10 |
| 2026-05-19 | NCT07585396 Inositol in Letrozol Resistant PCOS Women |
date change Completion moved earlier: 2027-09-14 -> 2026-05-11 |
| First Posted | Trial | Phase | Status |
|---|---|---|---|
| 2026-06-05 | NCT07628556 Antidiabetic Medications and Risk of Cancer | Completed | |
| 2026-05-22 | NCT07603505 Effect of NAE on Polycystic Ovarian Syndrome (PCOS) | Phase 1 | Active, Not Recruiting |
| 2026-05-22 | NCT07604870 Krill Oil and Metformin in Women With PCOS and Metabolically Unhealthy Obesity | Phase 2 | Completed |
| 2026-05-15 | NCT07589075 Sodium-Glucose Co-Transporter-2 Inhibitors as Adjuvant Therapy With Letrozole in… | Phase 4 | Completed |
| 2026-05-15 | NCT07589387 Hypertension Treatment in Nigeria: Hypertension Diabetes Integration Study- Formative Aim… | Not Yet Recruiting |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 4 | |||
| NCT06445946 | DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment… | Gestational Diabetes Mellitus | Recruiting |
| NCT07442006 | Glycemic Variability of Combination Therapies in T2DM | Type 2 Diabetes Mellitus (T2DM) | Recruiting |
| NCT05744479 | Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability | Intellectual Disability | Recruiting |
| NCT07001878 | Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis | Psychosis | Recruiting |
| NCT06829238 | Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV… | Systemic Inflammation | Recruiting |
| NCT03570632 | Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus | Diabetes Mellitus, Type 1 | Active, Not Recruiting |
| NCT07173712 | Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes | Type 2 Diabetes | Not Yet Recruiting |
| NCT06851962 | Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes. | Diabetes Mellitus Type 2 | Active, Not Recruiting |
| NCT07436182 | Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized… | Mitochondria | Not Yet Recruiting |
| NCT07485764 | Metformin Combined With Secukinumab for Moderate-to-Severe Plaque Psoriasis in Overweight… | Psoriasis | Not Yet Recruiting |
| NCT05366868 | Durable Effect of Imeglimin on the Glycemic Control in Patients With Type 2 Diabetes… | Diabetes Mellitus, Type 2 | Active, Not Recruiting |
| NCT06638671 | Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity | Exercise Capacity | Active, Not Recruiting |
| NCT07342764 | Dapagliflozin Versus Metformin for the Management of Antipsychotic-Induced Weight Gain: A… | Antipsychotic-induced Weight Gain (AIWG) | Not Yet Recruiting |
| Phase 3 | |||
| NCT06763328 | Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer… | Anatomic Stage I Breast Cancer AJCC v8 | Recruiting |
| NCT06231758 | Metformin Safety and Efficacy in Osteoarthritis. | Osteo Arthritis Knee | Recruiting |
| NCT04939935 | Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic… | Autosomal Dominant Polycystic Kidney Disease | Recruiting |
| NCT05445791 | Metformin Plus Tyrosine Kinase Inhibitors for Treatment of Patients With Non-small Cell… | Non Small Cell Lung Cancer | Recruiting |
| NCT05132439 | MetfOrmin BenefIts Lower Extremities With Intermittent Claudication | Intermittent Claudication | Recruiting |
| NCT06033131 | PI4 - A Trial Assessing Metformin to Prolong Gestation in Preterm Preeclampsia | Preeclampsia | Recruiting |
| NCT07045142 | Metformin Alleviates Abnormal Glucose Metabolism Induced by Statins in Schizophrenia… | Schizophrenia | Recruiting |
| NCT07475546 | Combination Gerotherapeutic Interventions for Healthspan Improvement | Healthspan Improvement | Active, Not Recruiting |
| NCT07520110 | Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis | Idiopathic Pulmonary Fibrosis | Not Yet Recruiting |
| NCT01905046 | Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia… | Atypical Ductal Breast Hyperplasia | Active, Not Recruiting |
| Phase 2/3 | |||
| NCT06975111 | Focusing on the Menopausal Transition to Improve Mid-Life Women's Health | Menopause | Recruiting |
| NCT06488625 | Efficacy and Safety of Oral Controlled-Ileocolonic-Release Nicotinamide (CICR-NAM) in… | Ulcerative Colitis, Unspecified | Recruiting |