Sponsor Pipeline

National Cancer Institute (NCI) Clinical Trial Pipeline

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
758
Active Trials
293
Recruiting
100
Phase 3
10
Disease Areas
166
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-06-12 NCT06917911
Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment…
Trial sites expanded: 7 -> 14 locations
2026-06-12 NCT07198074
Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin…
Trial sites expanded: 206 -> 211 locations
2026-06-12 NCT07061977
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation…
Trial sites expanded: 253 -> 260 locations
2026-06-12 NCT04847453
Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or…
date change Primary completion pushed: 2026-06-30 -> 2028-06-30
2026-06-12 NCT04847453
Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or…
date change Completion pushed: 2026-06-30 -> 2028-06-30
2026-06-12 NCT05950464
Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the…
date change Primary completion pushed: 2026-04-30 -> 2027-06-30
2026-06-12 NCT05950464
Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the…
date change Completion pushed: 2026-04-30 -> 2027-06-30
2026-06-12 NCT05691491
Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their…
Enrollment reduced: 58 -> 42 participants
2026-06-12 NCT04090398
Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy…
date change Primary completion pushed: 2026-06-30 -> 2027-06-30
2026-06-12 NCT04090398
Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy…
date change Completion pushed: 2026-06-30 -> 2027-06-30
2026-06-12 NCT02503722
Testing the Combination of MLN0128 (TAK-228) and AZD9291 in Advanced EGFR (Epidermal…
date change Primary completion pushed: 2026-06-05 -> 2027-02-28
2026-06-12 NCT02503722
Testing the Combination of MLN0128 (TAK-228) and AZD9291 in Advanced EGFR (Epidermal…
date change Completion pushed: 2026-06-05 -> 2027-02-28
2026-06-12 NCT07012044
A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With…
Trial sites expanded: 2 -> 5 locations
2026-06-12 NCT04190550
Testing the Addition of an Anti-cancer Drug, Navtemadlin, to the Usual Treatments…
date change Primary completion pushed: 2026-06-30 -> 2027-06-30
2026-06-12 NCT04190550
Testing the Addition of an Anti-cancer Drug, Navtemadlin, to the Usual Treatments…
date change Completion pushed: 2026-06-30 -> 2027-06-30
2026-06-12 NCT05372640
Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694…
date change Primary completion pushed: 2026-06-01 -> 2027-06-07
2026-06-12 NCT05372640
Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694…
date change Completion pushed: 2026-06-01 -> 2027-06-07
2026-06-12 NCT06179888
Iberdomide Versus Observation Off Therapy After Idecabtagene Vicleucel CAR-T for Multiple…
Recruitment suspended
2026-06-12 NCT04044365
Pediatric cGVHD Symptom Scale
overall status: "Recruiting" → "Active Not Recruiting"
2026-06-12 NCT04044365
Pediatric cGVHD Symptom Scale
Enrollment reduced: 420 -> 139 participants
Showing 20 of 166 changes detected in the last 30 days.
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-06-02 NCT07619521 Testing the Combination of Anti-Cancer Drugs, Selumetinib and DS-8201a, for Advanced… Phase 1/2 Not Yet Recruiting
2026-06-02 NCT07619534 Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer… Not Yet Recruiting
2026-05-26 NCT07605416 Testing an Experimental Approach to Treat Patients With Plasma Cell Leukemia, The QUANTUM… Phase 2 Not Yet Recruiting
Active Trials by Phase
Phase 4
1
Phase 3
81
Phase 2/3
19
Phase 2
301
Phase 1/2
79
Phase 1
153
Early Phase 1
1
Not specified
123
Active Trials — top 25 of 758
NCT IDTitleConditionStatus
Phase 4
NCT05237947 Single-Dose HPV Vaccination for the Prevention of Cervical Cancer in Young Adult Women in… Human Papillomavirus-Related Cervical Carcinoma Active, Not Recruiting
Phase 3
NCT04166409 A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With… Low Grade Astrocytoma Recruiting
NCT05256225 Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2… Endometrial Carcinoma Recruiting
NCT06498635 Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard… Lung Non-Small Cell Carcinoma Recruiting
NCT04181060 Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With… Advanced Lung Non-Squamous Non-Small Cell Carcinoma Recruiting
NCT04267848 Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy… Lung Non-Small Cell Carcinoma Recruiting
NCT04269902 Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or… Chronic Lymphocytic Leukemia Recruiting
NCT05675410 A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs… Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8 Recruiting
NCT06058377 Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment… Anatomic Stage II Breast Cancer AJCC v8 Recruiting
NCT06096844 Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With… Advanced Lung Non-Small Cell Carcinoma Recruiting
NCT06172296 Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of… Ganglioneuroblastoma, Nodular Recruiting
NCT06337318 Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden… Classic Follicular Lymphoma Recruiting
NCT06422806 Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for… Metastatic Dedifferentiated Liposarcoma Recruiting
NCT06524544 A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitean-hziy Versus… Locally Advanced Urothelial Carcinoma Recruiting
NCT06589804 Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment… Metastatic Head and Neck Squamous Cell Carcinoma Recruiting
NCT07061977 Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation… Locally Advanced Cervical Adenocarcinoma Recruiting
NCT07198074 Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin… Advanced Endometrial Carcinoma Recruiting
NCT07391774 Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed… Anatomic Stage II Breast Cancer AJCC v8 Recruiting
NCT00565851 Carboplatin, Paclitaxel and Gemcitabine Hydrochloride With or Without Bevacizumab After… Clear Cell Adenocarcinoma Active, Not Recruiting
NCT03871257 A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With… Low Grade Glioma Active, Not Recruiting
NCT01169337 Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering… Light Chain Deposition Disease Active, Not Recruiting
NCT00980460 Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer PRETEXT I Hepatoblastoma Active, Not Recruiting
NCT01886872 Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in… Stage I Chronic Lymphocytic Leukemia Active, Not Recruiting
NCT02443077 Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or… Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type Active, Not Recruiting
NCT03914612 Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy… Endometrial Clear Cell Adenocarcinoma Active, Not Recruiting
View all 758 active National Cancer Institute (NCI) trials with filters →
Disease Areas
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