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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

StatusRecruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

The 50 most recent of 999 record versions are listed below. See every version on ClinicalTrials.gov ↗

  1. Minor Site details revised at 9 of 1151 sites
  2. Minor Site details revised at 5 of 1151 sites
  3. Minor Site details revised at 9 of 1151 sites
  4. Minor Site details revised at 2 of 1151 sites
  5. Minor Site details revised at 2 of 1151 sites
Show 45 earlier versionsHide 45 earlier versions
  1. Minor Study sites revised (1151)
  2. Minor Re-verified, no change to tracked fields
  3. Minor Site details revised at 105 of 1151 sites
  4. Minor Site details revised at 1 of 1151 sitesv991
  5. Minor Site details revised at 4 of 1151 sitesv990
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  7. Minor Site details revised at 4 of 1151 sitesv988
  8. Minor Site details revised at 2 of 1151 sitesv987
  9. Minor Study sites: 1150 to 1151v986
  10. Minor Study sites revised (1150)v985 See this version in full on ClinicalTrials.gov ↗
  11. Minor Site details revised at 1 of 1150 sitesv984
  12. Minor Site details revised at 1 of 1150 sitesv983
  13. Minor Site contacts updated at 6 of 1150 sitesv982
  14. Minor Site details revised at 3 of 1150 sitesv981
  15. Minor Re-verified, no change to tracked fieldsv980
  16. Minor Site details revised at 1 of 1150 sitesv979
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  20. Minor Site details revised at 3 of 1150 sitesv975
  21. Minor Site details revised at 4 of 1150 sitesv974
  22. Minor Study sites: 1151 to 1150v973
  23. Minor Site details revised at 1 of 1151 sitesv972
  24. Minor Study sites revised (1151)v971 See this version in full on ClinicalTrials.gov ↗
  25. Minor Site details revised at 1 of 1151 sitesv970
  26. Minor Site details revised at 3 of 1151 sitesv969
  27. Minor Site contacts updated at 12 of 1151 sitesv968
  28. Minor Site details revised at 1 of 1151 sitesv967
  29. Minor Site details revised at 1 of 1151 sitesv966
  30. Minor Site details revised at 3 of 1151 sitesv965
  31. Minor Site details revised at 1 of 1151 sitesv964
  32. Minor Site details revised at 1 of 1151 sitesv963
  33. Minor Study sites: 1150 to 1151v962
  34. Minor Site details revised at 2 of 1150 sitesv961
  35. Minor Study sites revised (1150)v960 See this version in full on ClinicalTrials.gov ↗
  36. Minor Study sites revised (1150)v959 See this version in full on ClinicalTrials.gov ↗
  37. Minor Site details revised at 1 of 1150 sitesv958
  38. Minor Site details revised at 4 of 1150 sitesv957
  39. Minor Site details revised at 4 of 1150 sitesv956
  40. Minor Site details revised at 2 of 1150 sitesv955
  41. Minor Study sites revised (1150)v954 See this version in full on ClinicalTrials.gov ↗
  42. Minor Site details revised at 8 of 1150 sitesv953
  43. Minor Study sites: 1151 to 1150v952
  44. Minor Site details revised at 1 of 1151 sitesv951
  45. Minor Site details revised at 4 of 1151 sitesv950
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This phase III ALCHEMIST treatment trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB, IIIA or IIIB non-small cell lung cancer that has been removed by surgery. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as cisplatin, pemetrexed, carboplatin, gemcitabine hydrochloride, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab with usual chemotherapy may help increase survival times in patients with stage IIA, IIB, IIIA or IIIB non-small cell lung cancer.
Trial Details
NCT Number NCT04267848
Lead Sponsor National Cancer Institute (NCI)
Conditions Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma, Lung Non-Squamous Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8
Enrollment 1,210 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov