Disease landscape

Colorectal Cancer clinical trials

Get alerts when Colorectal Cancer trials change

2,227 active trials 1,270 recruiting 205 Phase 3 987 sponsors 264 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 56 of 264 changes on 20 trials

2026-08-14
Trial terminated
Trial terminated: Following completion of Phase 1b, the Sponsor decided not to initiate Part 2 of the trial.
Primary endpoint(s) modified
Primary completion moved earlier: 2025-07 → 2025-04-30
Completion moved earlier: 2025-11 → 2025-04-30
NCT05572684 A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants… · NextCure, Inc. · Phase 1/2
2026-08-01
Recruitment suspended
Recruitment suspended: Suspended due to lack of drug supply: the manufacturer ceased to provide investigational drug supply.
NCT07057089 Involved-field Radiotherapy-TNT Combined With PD-1 Inhibitor for pMMR Locally Advanced… · Hebei Medical University Fourth Hospital · Phase 2
2026-07-31
Trial status changed: Completed → Terminated
Trial terminated: target number of inclusion not reached
NCT03068403 Dynamic Contrast Enhanced Ultrasound for Predict and Assess Rectal Cancer Response After… · University Hospital, Bordeaux
2026-08-22
Primary completion pushed: 2028-02 → 2028-12
Recruitment opened
Trial sites expanded: 2 → 9 locations
Completion pushed: 2028-02 → 2028-12
NCT07429110 ColoSeal™ ICD System Anastomotic Protection Pivotal Study · Averto Medical, Inc.
2026-08-28
Primary completion pushed: 2028-08-31 → 2028-12-31
Completion moved earlier: 2029-11-30 → 2029-06-30
NCT07224022 Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer · John Strickler, M.D. · Phase 2
2026-08-14
Primary completion pushed: 2026-03 → 2027-03
Completion pushed: 2026-03 → 2027-03
NCT05288205 Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors… · Allist Pharmaceuticals, Inc. · Phase 1/2
2026-08-12
Primary completion pushed: 2026-10 → 2027-09
Trial sites reduced: 32 → 19 locations
Completion pushed: 2026-10 → 2027-09
NCT05592626 A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion… · Marengo Therapeutics, Inc. · Phase 1/2
2026-08-12
Primary completion pushed: 2025-06-30 → 2026-12-30
Sponsor changed: Evopoint Biosciences Inc. → Astellas Pharma Global Development, Inc.
Enrollment closed, study ongoing
Completion pushed: 2025-12-31 → 2027-06-30
NCT06792435 XNW27011 Study of Advanced Solid Tumor Subjects Who Failed Standard Therapies. · Astellas Pharma Global Development, Inc. · Phase 1/2
2026-07-31
Primary completion pushed: 2026-12 → 2028-01
Enrollment increased: 442 → 542 participants
Trial sites expanded: 79 → 82 locations
Completion pushed: 2027-12 → 2028-06
NCT04657068 A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors · Artios Pharma Ltd · Phase 1/2
2026-07-30
Primary completion pushed: 2025-11 → 2028-05
Primary endpoint(s) modified
Trial sites expanded: 45 → 54 locations
Completion pushed: 2027-11 → 2028-11
NCT03526835 A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors · Merus B.V. · Phase 1/2
2026-08-06
Primary completion pushed: 2026-05 → 2027-06
Primary endpoint(s) modified
Completion pushed: 2026-05 → 2027-06
Trial arms changed: 17 → 18
NCT04999761 AB122 Platform Study · Taiho Pharmaceutical Co., Ltd. · Phase 1
2026-08-28
Primary completion pushed: 2026-10-02 → 2028-02-13
Enrollment reopened
Enrollment increased: 33 → 51 participants
Completion pushed: 2026-12-20 → 2028-02-13
NCT04589468 Researching the Effect of Exercise on Cancer · City of Hope Medical Center
2026-08-06
Primary completion pushed: 2026-12-15 → 2027-12-15
Completion pushed: 2027-03-15 → 2028-03-15
NCT05826743 Safety and Effectiveness Evaluation of the COLO-BT as an Alternative Treatment to the… · JSR Medical Co., Ltd.
2026-08-22
Primary completion pushed: 2026-08-01 → 2027-08-01
Completion pushed: 2026-10-01 → 2027-10-01
NCT05148494 TES RCT Fleet Enema vs Oral Mechanical Bowel Prep · Nova Scotia Health Authority · Phase 4
2026-08-25
Primary completion pushed: 2028-11-30 → 2029-11-30
Recruitment opened
NCT07237984 Colorectal Omics and ofCS Proteoglycans (COCO) in Screening and a Diagnostic Pathway · Nordsjaellands Hospital
2026-08-18
Primary completion pushed: 2023-09-15 → 2026-09-15
NCT04246684 Short RT Versus RCT,Followed by Chemo and Organ Preservation for Interm and High-risk… · Prof. Dr. med. Claus Rödel · Phase 3
2026-08-21
Primary completion pushed: 2026-09 → 2027-09
Enrollment reduced: 160 → 41 participants
Enrollment closed, study ongoing
Completion pushed: 2026-09 → 2027-09
NCT05568420 A Study of the Possible Effects of Medication on Young Onset Colorectal Cancer (YOCRC) · Memorial Sloan Kettering Cancer Center
2026-08-21
Primary completion pushed: 2025-01 → 2028-05
Completion pushed: 2027-07 → 2028-05
NCT01792934 Chemotherapy and Maximal Tumor Debulking of Multi-organ Colorectal Cancer Metastases · Radboud University Medical Center
2026-07-30
Primary completion pushed: 2028-01-01 → 2028-10-01
Completion pushed: 2031-01-01 → 2031-10-01
NCT07004413 Continuous or Intermittent Cetuximab Plus FOLFIRI as First-line Treatment in RAS/BRAF… · Charite University, Berlin, Germany · Phase 3
2026-08-26
Primary endpoint(s) modified
NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… · Lumina Pharmaceuticals Inc · Early Phase 1

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07790510 HSK42360-Na Tablets Combined With Cetuximab With or Without Chemotherapy in BRAF… Haisco Pharmaceutical Group Co., Ltd. new Phase 1/2
2026-08-26 NCT07788729 Social Prescriptions and Micro-Learning to Improve Care for Cancer Patients and Their… University of Regensburg new
2026-08-25 NCT07784114 Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic… Beijing University of Chinese Medicine new
2026-08-24 NCT07781306 PrOspEctive Metastases Imaging (POEM) Cancer Research Antwerp new
2026-08-24 NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… Lumina Pharmaceuticals Inc new Early Phase 1
2026-08-21 NCT07780305 ABCSG R07 Rectal Cancer Registry Austrian Breast & Colorectal Cancer Study Group new
2026-08-21 NCT07778875 Health Belief Model-Based Education for Colorectal Cancer Screening Bartın Unıversity new
2026-08-14 NCT07766044 A One-year Follow-up of Incisional Hernia Formation Between Device Assisted and Manual… Suturion AB new
2026-08-13 NCT07763314 Trends and Short-term Outcomes of Surgically Resected Early-onset Colorectal Cancer in… Cantonal Hospital of St. Gallen new
2026-08-13 NCT07764120 Quality of Life of Patients After Rectal Cancer Resection . University Hospital, Grenoble new

Active trials by phase

Early Phase 1
28
Phase 1
204
Phase 1/2
180
Phase 2
515
Phase 2/3
37
Phase 3
168
Phase 4
22
Not charted: 1,073 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 2,227

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05148494 TES RCT Fleet Enema vs Oral Mechanical Bowel Prep Nova Scotia Health Authority Recruiting 2026-08-21
NCT07696793 Efficacy and Tolerability of a Simethicone-containing Evacuating Solution for Colorectal… Fundacion Clinic per a la Recerca Biomédica Recruiting 2026-07-10
NCT06562543 A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With… Takeda Recruiting 2026-07-07
NCT07209787 SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter… Beijing Chao Yang Hospital Recruiting 2026-06-17
NCT05726136 Fluid Challenge and Plasma Volume, During Surgery Joachim Zdolsek Recruiting 2026-04-30
NCT07158164 DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment Rutgers, The State University of New Jersey Recruiting 2025-11-13
NCT07215000 Cleansing Options in Out-Patient Setting to Improve Tolerance (COOP SIT) Trial Morehouse School of Medicine Recruiting 2025-10-09
NCT06090994 Prevention of Recurrence and Metastasis of Colorectal Cancer by Comparing Huaier With… Fudan University Recruiting 2025-05-07
NCT06550453 Safety and Efficacy of Pembrolizumab in Combination with Bevacizumab + CapeOX in the… yangjianjun Recruiting 2024-11-12
NCT05250648 Clinical Trial on HIPEC With Mitomycin C in Colon Cancer Peritoneal Metastases (GECOP-MMC) Hospital Universitario de Fuenlabrada Recruiting 2024-10-09
NCT06118762 Clinical Study of Fruquintinib Combined With Raltitrexed in the Treatment of Metastatic… The First Affiliated Hospital of Nanchang University Recruiting 2023-11-07
NCT05148767 UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer Zhejiang Cancer Hospital Recruiting 2021-12-08
NCT07768358 Tucatinib Continuation Study Pfizer Not Yet Recruiting 2026-08-17
NCT07094893 Anti-EGFR Agents in Patients With Right-sided Advanced Colorectal Cancer With Wild-type… Gruppo Oncologico del Nord-Ovest Not Yet Recruiting 2026-07-24
NCT07624916 Transversus Abdominis Plane and Rectus Sheath Block for Robotic Colectomy Tri-Service General Hospital Not Yet Recruiting 2026-06-03
NCT07483060 Next Generation STAR-TREC (NG-ST) - Organ Preservation in Early Rectal Cancer Vastra Gotaland Region Not Yet Recruiting 2026-03-19
NCT07446465 FOLFOX Chemotherapy Combined With Fruquintinib and Serplulimab as First-Line Conversion… Ye Xu Not Yet Recruiting 2026-03-03
NCT07152886 The Effects of Clostridium Butyricum on Adverse Events During Adjuvant Chemotherapy for… The Affiliated Hospital of Qingdao University Not Yet Recruiting 2025-09-03
NCT07020468 Neoadjuvant Therapy （NALIRIFOX） for Locally Advanced Colon and Upper Rectal Cancer Affiliated Cancer Hospital of Shantou University Medical College Active, Not Recruiting 2025-06-13
NCT06881563 Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery Meri Mirceta Not Yet Recruiting 2025-03-18
NCT06665334 To Explore the Effect of Huaier Granule on the Negative Conversion Rate After the CEA… Fudan University Not Yet Recruiting 2024-10-31
NCT04281667 Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation… Helsinki University Central Hospital Active, Not Recruiting 2022-11-17
Phase 3
NCT07775287 Study of Petosemtamab Plus Chemotherapy Versus Cetuximab or Bevacizumab Plus Chemotherapy… Genmab Recruiting 2026-08-26
NCT07669519 Evaluation of NuvastaticTM in Reducing Cancer-Related Fatigue in Colon Cancer Patients… Natureceuticals Sdn Bhd Recruiting 2026-08-25
NCT06252649 Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without… Amgen Recruiting 2026-08-21
See all 2,227 active Colorectal Cancer trials with filters →

Top sponsors by active trials in this area

Fudan University (75) · Sun Yat-sen University (66) · M.D. Anderson Cancer Center (45) · National Cancer Institute (NCI) (34) · City of Hope Medical Center (27) · Memorial Sloan Kettering Cancer Center (25) · Sixth Affiliated Hospital, Sun Yat-sen University (24) · Peking University Cancer Hospital & Institute (18) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (18) · West China Hospital (18)

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