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NCT01792934 · ClinicalTrials.gov record · last posted 2026-08-20

Chemotherapy and Maximal Tumor Debulking of Multi-organ Colorectal Cancer Metastases

Study acronym: ORCHESTRA
StatusActive, Not Recruiting
PhaseNot applicable
Started2013-05
View on ClinicalTrials.gov ↗
from the ClinicalTrials.gov record
The purpose of this study is to compare overall survival rates of colorectal cancer patients with multi-organ metastases with an indication for first line systemic treatment randomized for treatment with combination chemotherapy or treatment with combination chemotherapy and additional maximal tumor debulking including surgical tumor resection, RFA, (DEBIRI-)TACE and SBRT, depending on best clinical judgement according to a standardized treatment algorithm. Our hypothesis is that maximal tumor debulking in addition to systemic treatment with chemotherapy and biologicals will provide an improvement in progression free and overall survival in this patient group.

Protocol amendment history 2 changes detected by DataLookout

2026-08-21
Primary completion pushed: 2025-01 → 2028-05
2026-08-21
Completion pushed: 2027-07 → 2028-05
Trial Details
NCT Number NCT01792934
Lead Sponsor Radboud University Medical Center
Collaborators: Erasmus Medical Center
Conditions Multi-organ Metastatic Colorectal Cancer
Enrollment 478 participants
Start Date 2013-05
Primary Completion 2028-05 (estimated)
Study Completion 2028-05 (estimated)
Updated on ClinicalTrials.gov 2026-08-20