Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT04181060 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

StatusRecruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 2 years 6 months later Dec 31, 2026 → Jun 30, 2029
See other at-risk trials from National Cancer Institute (NCI)

Record History

The 50 most recent of 648 record versions are listed below. See every version on ClinicalTrials.gov ↗

  1. Minor Site details revised at 1 of 603 sites
  2. Minor Site details revised at 2 of 603 sites
  3. Minor Site details revised at 3 of 603 sites
  4. Minor Site details revised at 2 of 603 sites
  5. Notable Primary and study completion pushed from Dec 31, 2026 to Jun 30, 2029 Study sites revised (603) Show 1 more changeShow less
    • Study sites revised (603)
Show 45 earlier versionsHide 45 earlier versions
  1. Notable Primary and study completion dates: Dec 31, 2026 to Jun 30, 2029 Site contacts updated at 1 of 603 sites Show 1 more changeShow less
    • Site contacts updated at 1 of 603 sites
  2. Minor Site details revised at 38 of 603 sites
  3. Minor Site details revised at 2 of 603 sitesv641
  4. Minor Site details revised at 5 of 603 sitesv640
  5. Minor Site details revised at 4 of 603 sitesv639
  6. Minor Site contacts updated at 1 of 603 sitesv638
  7. Minor Site details revised at 2 of 603 sitesv637
  8. Minor Site details revised at 2 of 603 sitesv636
  9. Minor Site details revised at 1 of 603 sitesv635
  10. Minor Site details revised at 1 of 603 sitesv634
  11. Minor Site details revised at 1 of 603 sitesv633
  12. Minor Site details revised at 2 of 603 sitesv632
  13. Minor Study sites: 604 to 603v631
  14. Minor Study sites revised (604)v630 See this version in full on ClinicalTrials.gov ↗
  15. Minor Site details revised at 1 of 604 sitesv629
  16. Minor Site details revised at 1 of 604 sitesv628
  17. Minor Site details revised at 1 of 604 sitesv627
  18. Minor Study sites revised (604)v626 See this version in full on ClinicalTrials.gov ↗
  19. Minor Study sites: 603 to 604v625
  20. Minor Site details revised at 1 of 603 sitesv624
  21. Minor Site details revised at 1 of 603 sitesv623
  22. Minor Site details revised at 1 of 603 sitesv622
  23. Minor Site details revised at 2 of 603 sitesv621
  24. Minor Site details revised at 2 of 603 sitesv620
  25. Minor Site details revised at 1 of 603 sitesv619
  26. Minor Site details revised at 4 of 603 sitesv618
  27. Minor Study sites revised (603)v617 See this version in full on ClinicalTrials.gov ↗
  28. Minor Site details revised at 1 of 603 sitesv616
  29. Minor Site details revised at 5 of 603 sitesv615
  30. Minor Site details revised at 1 of 603 sitesv614
  31. Minor Study sites revised (603)v613 See this version in full on ClinicalTrials.gov ↗
  32. Minor Site details revised at 9 of 603 sitesv612
  33. Minor Study sites: 604 to 603v611
  34. Minor Site details revised at 1 of 604 sitesv610
  35. Minor Site details revised at 3 of 604 sitesv609
  36. Minor Site details revised at 5 of 604 sitesv608
  37. Minor Study sites revised (604)v607 See this version in full on ClinicalTrials.gov ↗
  38. Minor Re-verified, no change to tracked fieldsv606
  39. Minor Site details revised at 1 of 604 sitesv605
  40. Minor Site details revised at 7 of 604 sitesv604
  41. Minor Site details revised at 6 of 604 sitesv603
  42. Minor Site details revised at 6 of 604 sitesv602
  43. Minor Site details revised at 4 of 604 sitesv601
  44. Minor Site details revised at 5 of 604 sitesv600
  45. Minor Site details revised at 1 of 604 sitesv599
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.
Trial Details
NCT Number NCT04181060
Lead Sponsor National Cancer Institute (NCI)
Conditions Advanced Lung Non-Squamous Non-Small Cell Carcinoma, Metastatic Lung Non-Squamous Non-Small Cell Carcinoma, Recurrent Lung Non-Squamous Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
Enrollment 300 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov