Disease landscape

Parkinson's Disease clinical trials

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1,095 active trials 642 recruiting 24 Phase 3 587 sponsors 109 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 43 of 109 changes on 20 trials

2026-08-20
Withdrawn before enrolling
Trial withdrawn: Has yet to begin and may not so halting to avoid participant outreach
Enrollment reduced: 32 → 0 participants
NCT05931484 Study to Evaluate the Safety, Tolerability, Efficacy, and PK of FHL-301 in Parkinson's… · Forest Hills Lab · Phase 2
2026-08-22
Primary completion pushed: 2025-10 → 2027-02
Completion pushed: 2025-10 → 2027-02
NCT06466525 A Two-Part Single and Multiple Ascending Dose Trial of the Safety, Tolerability… · Longevity Biotech Australia Pty Ltd (subsidiary) · Phase 1
2026-08-20
Primary completion pushed: 2026-03-30 → 2026-11-30
Completion pushed: 2026-03-30 → 2026-11-30
NCT07175922 Research Into the Expression of the csgA-gene and How it Changes in Patients With… · Vertero Therapeutics
2026-08-25
Primary completion pushed: 2026-05-31 → 2026-10-31
Completion pushed: 2026-05-31 → 2026-10-31
NCT04664634 A Digital Therapeutic Platform for Swallowing and Drooling Problems in Parkinson's · Northwestern University · Phase 3
2026-07-30
Primary completion pushed: 2028-12-15 → 2029-06-15
Completion pushed: 2032-06-15 → 2032-12-15
NCT07566429 A Study of AB-1005 Gene Therapy in Japanese Adults With Moderate Parkinson's Disease… · Bayer · Phase 2
2026-08-20
Primary completion pushed: 2026-10-24 → 2027-10-24
Completion pushed: 2027-08-24 → 2028-08-24
NCT04373317 Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis · VA Office of Research and Development · Phase 4
2026-08-26
Primary completion pushed: 2026-06-01 → 2026-10-01
NCT06592014 Lithium for Parkinson's: an Extension Trial · State University of New York at Buffalo · Phase 1/2
2026-08-28
Primary completion pushed: 2027-03-01 → 2027-08-15
Completion pushed: 2027-03-01 → 2027-08-15
NCT07399496 Accelerated rTMS for Apathy in Parkinson's Disease · Medical University of South Carolina
2026-08-28
Primary completion pushed: 2027-12-01 → 2028-12-01
Completion pushed: 2027-12-01 → 2028-12-01
NCT06193252 Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands · Radboud University Medical Center
2026-08-21
Primary completion pushed: 2028-06-30 → 2032-12-31
Completion pushed: 2030-06-30 → 2034-12-31
NCT04888364 French Parkinson's Disease Cohort - NS-PARK · Institut National de la Santé Et de la Recherche Médicale, France
2026-08-27
Primary completion pushed: 2026-08 → 2027-08
Completion pushed: 2026-08 → 2027-08
NCT00575081 Physiological Brain Atlas Development · Vanderbilt University Medical Center
2026-08-25
Primary completion pushed: 2026-06 → 2028-06
Completion pushed: 2026-06 → 2028-06
NCT06994728 Correlation of STN-DBS Induced Visuospatial Changes and Freezing of Gait · Medical University of South Carolina
2026-08-22
Primary completion pushed: 2025-01-01 → 2027-01-01
Recruitment opened
NCT06576713 Combined Genome and RNA Sequencing for Genetic Diagnosis of Parkinsonism · University Hospital, Strasbourg, France
2026-08-21
Primary completion pushed: 2026-05-31 → 2026-10-31
Enrollment closed, study ongoing
Completion pushed: 2026-05-31 → 2026-10-31
NCT05014971 Telehealth in Lewy Body Dementia · University of Florida
2026-08-18
Primary completion pushed: 2025-02-28 → 2027-12-28
Primary endpoint(s) modified
NCT06482268 Transplantation of Human iPS Cell-derived Dopaminergic Progenitors (CT1-DAP001) for… · University of California, San Diego · Phase 1
2026-07-31
Primary completion pushed: 2026-09 → 2027-09
Completion pushed: 2026-09 → 2027-09
NCT05514106 MIBG in Aging and Neurologic Disorders · Mayo Clinic · Phase 4
2026-08-12
Primary completion pushed: 2025-10-31 → 2026-04-17
Enrollment reduced: 120 → 76 participants
Completed without a posted recruiting period
Completion pushed: 2025-12-31 → 2026-04-17
NCT07063810 NEO-REEDUC - Mixed Reality for Motor Rehabilitation: a Prospective, Multicenter… · Slb Pharma
2026-08-11
Primary completion pushed: 2027-12-31 → 2029-12-31
Completion pushed: 2027-12-31 → 2029-12-31
NCT06209515 Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease… · Kuopio University Hospital
2026-08-08
Primary completion pushed: 2026-08-15 → 2026-12-15
Completion pushed: 2026-08-15 → 2027-01-15
NCT05400174 Blood Pressure Effects on Cognition and Brain Blood Flow in PD · University of California, San Diego
2026-08-06
Primary completion pushed: 2026-06 → 2026-12
Completion pushed: 2026-06 → 2026-12
NCT06154356 Action Observation and Motor Imagery Therapy in Parkinson's Disease · Karamanoğlu Mehmetbey University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07790094 Segmental Laser Acupuncture for Constipation and Sleep in Patients With Parkinson's… China Medical University Hospital new
2026-08-26 NCT07787299 Wearable for Assessing Tremor and Continuous Health in Parkinson's and Essential Tremor… Heriot-Watt University new
2026-08-25 NCT07786116 The Role of METhanogens in the PROgression Of Parkinson's Disease and Related… University of Cambridge new
2026-08-24 NCT07781696 CnF-DBS for Levodopa-Resistant FOG Iahn Cajigas new
2026-08-21 NCT07780461 Characterization and Validation of the Short Physical Performance Battery in Individuals… University of Vigo new
2026-08-20 NCT07777484 An Unblinded, Single Arm, Pilot Observational Study to Test the Safety, Tolerability… Tridem Bioscience FlexCo new Phase 1
2026-08-17 NCT07767006 Neuromodulation for Patients With Parkinson's Disease Felipe Fregni, MD, PhD, MPH new
2026-08-13 NCT07761936 Safinamide vs Placebo for Pain in Patients With Parkinson's Disease and Motor Fluctuations Universita di Verona new Phase 3
2026-08-06 NCT07749261 Gut Microbiota and Tryptophan Metabolites in Parkinson's Disease Ningxia Medical University new
2026-08-06 NCT07748715 Brain Dopamine Biomarker University of South Florida new

Active trials by phase

Early Phase 1
17
Phase 1
58
Phase 1/2
27
Phase 2
70
Phase 2/3
8
Phase 3
16
Phase 4
21
Not charted: 878 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,095

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06013956 Personalized Real-Time DBS and PD Mechanisms David Escobar Recruiting 2026-08-20
NCT04373317 Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis VA Office of Research and Development Recruiting 2026-08-19
NCT06951906 Imaging Biomarkers of FOG Response to DBS Medical University of South Carolina Recruiting 2026-08-10
NCT05357612 Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients… Vanderbilt University Medical Center Recruiting 2026-08-07
NCT07138560 BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease The Cleveland Clinic Recruiting 2026-06-23
NCT06234995 Cortical Electrophysiology of Response Inhibition in Parkinson's Disease Emory University Recruiting 2026-03-27
NCT07284290 Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body… Virginia Commonwealth University Recruiting 2026-03-06
NCT06634641 Clozapine-related Immunodeficiency in Parkinsons Disease Centre Hospitalier Universitaire, Amiens Recruiting 2025-11-19
NCT05590637 Comparing Antipsychotic Medications in LBD Over Time The University of Texas Health Science Center at San Antonio Recruiting 2025-09-09
NCT06765668 A Study of CREXONT (Carbidopa and Levodopa) Extended-Release Capsules in Participants… Impax Laboratories, LLC Recruiting 2025-08-24
NCT06710574 Multimodal Image Technologies Investigate the Role and Mechanism of Probiotics in… Beijing Friendship Hospital Recruiting 2024-12-02
NCT06316232 DBS and Levodopa for Treating Freezing of Gait in Parkinson's Disease IRCCS Istituto delle Scienze Neurologiche di Bologna Recruiting 2024-03-18
NCT03495024 Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological… Corporal Michael J. Crescenz VA Medical Center Recruiting 2019-03-22
NCT05514106 MIBG in Aging and Neurologic Disorders Mayo Clinic Enrolling by Invitation 2026-07-30
NCT07187466 Behavioral and/or Mirabegron to Treat Urinary Symptoms in Parkinson Disease VA Office of Research and Development Not Yet Recruiting 2026-07-22
NCT07384429 Effects of Lemborexant on Motor-sleep Comorbidity in Parkinson's Disease YangPan Not Yet Recruiting 2026-06-11
NCT07627529 Pilot Deprescribing of Antimuscarinic Overactive Bladder Medications in Parkinson Disease Corporal Michael J. Crescenz VA Medical Center Not Yet Recruiting 2026-06-04
NCT07483398 RELIEF-PD: Crisugabalin for Nociplastic Pain in Parkinson's Disease Guangdong Provincial People's Hospital Active, Not Recruiting 2026-03-19
NCT01453127 DaTSCAN Imaging in Aging and Neurodegenerative Disease Mayo Clinic Enrolling by Invitation 2026-03-10
NCT02670161 Quality Improvement and Practice Based Research in Neurology Using the EMR Endeavor Health Enrolling by Invitation 2025-08-24
NCT06805266 Vortioxetine for Depressive Symptoms and Freezing of Gait in Parkinson Disease Marianna Amboni Not Yet Recruiting 2025-02-06
Phase 3
NCT04664634 A Digital Therapeutic Platform for Swallowing and Drooling Problems in Parkinson's Northwestern University Recruiting 2026-08-24
NCT07761936 Safinamide vs Placebo for Pain in Patients With Parkinson's Disease and Motor Fluctuations Universita di Verona Recruiting 2026-08-13
NCT07174310 A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in… Hoffmann-La Roche Recruiting 2026-08-06
NCT06944522 A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have… BlueRock Therapeutics Recruiting 2026-08-04
See all 1,095 active Parkinson's Disease trials with filters →

Top sponsors by active trials in this area

University of Minnesota (17) · VA Office of Research and Development (13) · Ruijin Hospital (12) · Radboud University Medical Center (11) · InSightec (10) · Vanderbilt University Medical Center (10) · AbbVie (9) · Stanford University (9) · University of Alabama at Birmingham (9) · Washington University School of Medicine (9)

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