Clinical Trial

Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia

Recruiting Phase 4
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Summary
The proposed study aims to address the critical gaps in understanding the mechanisms of CF (Cognitive Fluctuations) by leveraging recently emerged molecular biomarkers, advanced neuroimaging techniques to assess measures of cholinergic degeneration, and synchronous EEG and assessments of attention. One of the overarching innovations of study is combining all of these assessments into one integrated research plan
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-12-12; most recent amendment 2026-03-04.
Trial Details
NCT Number NCT07284290
Lead Sponsor Virginia Commonwealth University
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions Dementia With Lewy Bodies, Parkinson Disease Dementia, Healthy Controls
Enrollment 120 participants
Start Date 2025-12-08
Primary Completion 2029-11 (estimated)
Study Completion 2029-11 (estimated)
Updated on ClinicalTrials.gov 2026-03-06