Imaging Biomarkers of FOG Response to DBS

For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS). The objective of this study is to better understand the FOG response to DBS. Prior to DBS, participants will undergo an MRI scan, behavioral assessment related to walking, a cognitive evaluation, and assessment of other Parkinson's disease symptoms. Following DBS, participants will repeat these assessments at multiple timepoints over the period of one year. Overall, participants will complete a total of 7 visits over a period of approximately 1 year.

NCT Number	NCT06951906
Lead Sponsor	Medical University of South Carolina Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions	Freezing of Gait Symptoms in Parkinson's Disease, Deep Brain Stimulation
Enrollment	54 participants
Start Date	2024-11-11
Primary Completion	2029-11 (estimated)
Study Completion	2030-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-10