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NCT07781696 · ClinicalTrials.gov record · last posted 2026-08-24

CnF-DBS for Levodopa-Resistant FOG

Study acronym: CnF-DBS-FOG
StatusNot Yet Recruiting
PhaseNot applicable
Started2026-09
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from the ClinicalTrials.gov record
The purpose of this trial is to study the safety, practicality, and effectiveness of deep brain stimulation (DBS) therapy in a brain region called the cuneiform nucleus (CnF) to treat disabling freezing of gait (FOG) in patients with Parkinson's disease (PD) when standard treatments are no longer effective. The study uses either the Medtronic's Percept™ PC or RC systems for DBS therapy. Please note that although the Medtronic systems are FDA-approved for other diseases, they have not been approved for the treatment of FOG in PD and their use for stimulation of the CnF target is experimental.
Trial Details
NCT Number NCT07781696
Lead Sponsor Iahn Cajigas
Collaborators: University of Miami, University of California, San Francisco, Michael J. Fox Foundation for Parkinson's Research
Conditions Freezing of Gait Symptoms in Parkinson Disease
Enrollment 18 participants
Start Date 2026-09
Primary Completion 2028-08 (estimated)
Study Completion 2028-08 (estimated)
Updated on ClinicalTrials.gov 2026-08-24