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NCT06013956 · ClinicalTrials.gov record · last posted 2026-08-20

Personalized Real-Time DBS and PD Mechanisms

StatusRecruiting
PhasePhase 4
Started2023-08-29
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from the ClinicalTrials.gov record
A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS) implantation surgery for the treatment of Parkinson's disease as per standard of care will be invited to participate in this study. This mechanistic study is aimed at better understanding the role of basal ganglia beta band (11-35 Hz) oscillations and resonance in the manifestation of Parkinson's disease (PD) motor signs using closed-loop electrical neurostimulation, levodopa medication, and computational modeling. The ultimate goal of this study is to inform the development of closed-loop neuromodulation technology that can be programmed and adjusted in real time based on patient-specific neural activity.

Amendment record 4 amendments on the ClinicalTrials.gov record

This ClinicalTrials.gov record has been amended 4 times since 2023-08-25; most recent amendment 2026-05-12. DataLookout shows field-level changes from the day a trial enters its daily monitoring; earlier amendments are counted here from the ClinicalTrials.gov version history. See every version on ClinicalTrials.gov ↗

Trial Details
NCT Number NCT06013956
Lead Sponsor David Escobar
Collaborators: The Cleveland Clinic
Conditions Parkinson Disease
Enrollment 25 participants
Start Date 2023-08-29
Primary Completion 2028-06-30 (estimated)
Study Completion 2028-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-20