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Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases

StatusRecruiting
PhasePhase 4
Started2023-01-23
View on ClinicalTrials.gov ↗

Amendment history

2026-08-04
Study Status, Sponsor/Collaborators v8
Re-verified, no change to tracked fields
2026-07-16
Study Status, Oversight v7
Primary completion date2026-06→2027-06
Completion date2026-08→2027-08
2025-08-06
Study Status, Contacts/Locations v6
Primary completion date2025-06→2026-06
Completion date2025-08→2026-08
Study sitescontacts updated at 1 of 1 site
2025-04-04
Study Status, Oversight v5
Re-verified, no change to tracked fields
2024-02-27
Study Status v4
Primary completion date2024-06→2025-06
Completion date2024-08→2025-08
Show 3 earlier versions
2023-02-14
Study Status v3
Re-verified, no change to tracked fields
2023-01-24
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
Start date2022-11→2023-01-23
Study sites0→1
2022-08-12
Study Status v1
Start date2022-06→2022-11
2022-04-26
Original filing
It is hypothesize that patients with clinically diagnosed neurodegenerative diseases will have significantly different receptor occupancy of 5HT2A receptors compared to a healthy age/sex-matched control group. This will be tested by measuring 5HT2A receptor density using the PET radioligand (R)-\[18F\]MH.MZ in both populations.
Trial Details
NCT Number NCT05357612
Lead Sponsor Vanderbilt University Medical Center
Collaborators: ACADIA Pharmaceuticals Inc.
Conditions Neurodegenerative Diseases, Parkinson Disease, Parkinson Disease Psychosis
Enrollment 75 participants
Start Date 2023-01-23
Primary Completion 2027-06 (estimated)
Study Completion 2027-08 (estimated)
Updated on ClinicalTrials.gov 2026-08-07