University of Pittsburgh clinical trial pipeline

16 trials changed in the last 30 days: 1 stopped, 8 with notable changes, 7 with minor changes only.

1. Stopped

   TPS-ECC · Pittsburgh Study Early Childhood

   Trial terminated

   Also in this update: Final enrollment: 2546 participants (planned 24000); Primary completion date changed from estimate of Dec 2030 to Jun 30, 2026

   University of Pittsburgh·Not applicable· NCT05444205· Registry history of NCT05444205 on ClinicalTrials.gov (opens the registry)

   Oct 13, 2026

2. Notable

   PRESENCE · Peer Support for Adolescents and Emerging · Sickle…PRESENCE · Peer Support for Adolescents and Emerging · Sickle Cell Pain

   Primary completion pushed from Jul 2027 to Feb 2028

   Also in this update: Enrollment reduced: 470 → 390 participants; Study completion pushed from May 2028 to Aug 2028

   University of Pittsburgh·Not applicable· NCT06374238· Registry history of NCT06374238 on ClinicalTrials.gov (opens the registry)

   Oct 8, 2026

3. Notable

   Autologous Fresh Fat Grafting Followed by Autologous Cryopreserved…Autologous Fresh Fat Grafting Followed by Autologous Cryopreserved Fat Grafting

   Primary and study completion pushed from Dec 31, 2027 to Dec 31, 2028

   University of Pittsburgh·Not applicable· NCT06747715· Registry history of NCT06747715 on ClinicalTrials.gov (opens the registry)

   Oct 7, 2026

4. Notable

   Use of ctDNA for Monitoring of Stage III Colorectal Cancer

   Primary and study completion pushed from Sep 2026 to Sep 2027

   University of Pittsburgh·Not specified· NCT02842203· Registry history of NCT02842203 on ClinicalTrials.gov (opens the registry)

   Oct 6, 2026

5. Notable

   Natural History and Advanced Genetic Study of Pyruvate…Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies

   Primary completion pushed from Sep 2026 to Sep 2030

   Also in this update: Study completion pushed from Sep 2026 to Dec 2030

   University of Pittsburgh·Not specified· NCT03056794· Registry history of NCT03056794 on ClinicalTrials.gov (opens the registry)

   Oct 5, 2026

6. Notable

   Knee Replacement Rehabilitation Care Pathways

   Enrollment reduced: 275 → 30 participants

   Also in this update: Recruitment opened; Interventions modified

   University of Pittsburgh·Not applicable· NCT07598539· Registry history of NCT07598539 on ClinicalTrials.gov (opens the registry)

   Oct 13, 2026

7. Notable

   REFLECT2D · Real-time Engagement for Learning to Effectively…REFLECT2D · Real-time Engagement for Learning to Effectively Control Type 2 Diabetes

   Recruitment opened

   Also in this update: Start date changed from estimate of Sep 30, 2026 to Sep 20, 2026

   University of Pittsburgh·Not applicable· NCT06375460· Registry history of NCT06375460 on ClinicalTrials.gov (opens the registry)

   Oct 7, 2026

8. Notable

   Preventing Lymphedema in Patients Undergoing Surgical Treatment for…Preventing Lymphedema in Patients Undergoing Surgical Treatment for Head and Neck Cancer Through Vein Reconstruction

   Recruitment opened

   University of Pittsburgh·Not applicable· NCT07694726· Registry history of NCT07694726 on ClinicalTrials.gov (opens the registry)

   Oct 6, 2026

9. Notable

   Brain Mechanisms Involved in the Urinary Continence Mechanism…Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging

   Results posted: Oct 5, 2026

   University of Pittsburgh·Not applicable· NCT04599088· Registry history of NCT04599088 on ClinicalTrials.gov (opens the registry)

   Oct 5, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.