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Investigation of Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging

StatusCompleted
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Results posted: Oct 5, 2026 Primary endpoints revised (3) · Enrollment target: 207 to 217 · Eligibility criteria expanded, about 33 words Show 3 more changesShow less
    • Primary endpoints revised (3)
    • Enrollment target: 207 to 217
    • Eligibility criteria expanded, about 33 words
  2. Primary endpoints: 1 to 3 Secondary endpoints shortened, about 32 wordsv14 Show 1 more changeShow less
    • Secondary endpoints shortened, about 32 words

    See this version in full on ClinicalTrials.gov ↗

  3. Trial completedv13
  4. Completion date: Feb 3, 2026 to Apr 1, 2026v12
  5. Completion date: Jan 3, 2026 to Feb 3, 2026v11
Show 9 earlier versionsHide 9 earlier versions
  1. Trial status: Recruiting to Active, Not Recruiting Enrollment target: estimated 190 to confirmed 207 · Primary completion date changed from estimate of Aug 31, 2025 to Jul 31, 2025 · Completion date: Nov 30, 2025 to Jan 3, 2026 · 1 morev10 Show 4 more changesShow less
    • Enrollment target: estimated 190 to confirmed 207
    • Primary completion date changed from estimate of Aug 31, 2025 to Jul 31, 2025
    • Completion date: Nov 30, 2025 to Jan 3, 2026
    • Site details revised
  2. Primary completion date: May 31, 2025 to Aug 31, 2025v9
  3. Re-verified, no change to tracked fieldsv8
  4. Primary completion date: May 2025 to May 31, 2025 Completion date: Nov 2025 to Nov 30, 2025v7 Show 1 more changeShow less
    • Completion date: Nov 2025 to Nov 30, 2025
  5. Site contact updatedv6
  6. 2 versions Re-verified since Feb 23, 2022, no change to tracked fieldsv4-v5
  7. Start date changed from estimate of Jan 2021 to Dec 14, 2020v3
  8. Trial status: Not Yet Recruiting to Recruiting Start date: Nov 2020 to Jan 2021 · Site details revisedv2 Show 2 more changesShow less
    • Start date: Nov 2020 to Jan 2021
    • Site details revised
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Urge urinary incontinence (UUI) is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will characterize brain control of the bladder in young and old continent individuals and age-matched incontinent counterparts. This will expand the investigators current knowledge of how the brain controls the bladder, how that control changes with age and disease, and suggest new targets to guide development of better treatment.
Trial Details
NCT Number NCT04599088
Lead Sponsor University of Pittsburgh
Collaborators: National Institute on Aging (NIA)
Conditions Urgency Urinary Incontinence
Enrollment 217 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov