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Regeneron Pharmaceuticals clinical trial pipeline

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120 active trials 70 recruiting 37 Phase 3 31 disease areas 54 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-11

What changed in the last 30 days showing 37 of 54 changes on 19 trials

2026-10-09
Primary completion pushed from Dec 10, 2028 to Jul 8, 2030
Primary endpoint(s) modified
Completion pushed from Dec 21, 2029 to Jul 8, 2030
NCT07559513 A Study to Investigate the Safety, Pharmacokinetics (PK), and Efficacy of Garetosmab in… · Phase 3
2026-09-25
Primary completion pushed from Mar 25, 2027 to Nov 8, 2028
Completion pushed from Nov 30, 2027 to Nov 8, 2028
NCT04590326 A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given… · Phase 1/2
2026-09-12
Primary completion pushed from Sep 24, 2027 to Oct 13, 2028
Enrollment reduced: 270 → 195 participants
Completion pushed from Apr 7, 2028 to Oct 13, 2028
Interventions modified
NCT07271186 Study to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney Disease · Phase 2
2026-09-19
Primary endpoint(s) modified
Results posted: 2026-09-18
NCT06491914 A Phase 3b, Single-Arm Study of Aflibercept 8 mg Dosed Every 4 Weeks in Adult… · Phase 3
2026-10-07
Recruitment opened
NCT07759167 Study of 3 Monoclonal Antibodies (REGN9933, REGN7508, and REGN9533) in Adult Participants… · Phase 1
2026-09-30
Recruitment opened
NCT07697599 Venous Thromboembolism (VTE) Prophylaxis With REGN7508 and REGN9933 in Adult and… · Phase 3
2026-10-01
Trial completed
NCT06669234 Phase 1 Safety and Tolerability Study of ALN-F1202 in Healthy Adults · Phase 1
2026-09-29
Recruitment opened
Primary completion pushed from Jul 25, 2029 to Sep 14, 2029
Completion pushed from Oct 16, 2029 to Dec 6, 2029
NCT07675824 REGN22530 for Adults With Primary Open Angle Glaucoma or Ocular Hypertension · Phase 1/2
2026-09-17
Enrollment closed, study ongoing
Primary completion moved earlier from Apr 22, 2032 to Jul 6, 2027
Trial sites reduced: 40 → 29 locations
Final enrollment: 95 participants (planned 231)
Completion moved earlier from Apr 22, 2032 to Jul 6, 2027
NCT04077099 A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor… · Phase 1/2
2026-09-29
Trial completed
Final enrollment: 12343 participants (planned 3930)
Primary completion date changed from estimate of Jan 21, 2027 to Apr 13, 2026
NCT03936335 An Observational Retrospective Cohort Study Being Conducted in Women With Atopic…
2026-10-02
Primary completion pushed from Aug 20, 2027 to Jan 28, 2028
Completion pushed from Dec 8, 2027 to May 17, 2028
NCT07235917 A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea · Phase 2
2026-09-22
Primary completion pushed from Jan 6, 2027 to May 5, 2027
Completion pushed from Jan 6, 2027 to May 5, 2027
NCT05259709 A Study of ImmunoPet Imaging Using 89Zr-DFO-REGN5054 in Adult Participants With Solid… · Phase 1
2026-10-09
Trial sites expanded: 46 → 49 locations
NCT07213778 REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee… · Phase 3
2026-10-09
Trial sites expanded: 34 → 45 locations
NCT07626411 Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation · Phase 3
2026-10-09
Trial sites expanded: 28 → 39 locations
NCT07222761 A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination… · Phase 3
2026-10-10
Trial sites expanded: 84 → 87 locations
NCT07175428 Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation · Phase 2
2026-10-08
Trial sites expanded: 190 → 194 locations
NCT06091865 A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it… · Phase 3
2026-09-30
Trial sites expanded: 24 → 28 locations
NCT07222761 A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination… · Phase 3
2026-09-29
Trial sites expanded: 6 → 12 locations
NCT07493304 Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants… · Phase 3
2026-09-30
Trial sites expanded: 5 → 18 locations
NCT07685808 Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without… · Phase 2

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-10-07 NCT07863024 Safety and Efficacy Study in Adults With Advanced Solid Tumors Receiving… Phase 1/2 Not Yet Recruiting
2026-10-06 NCT07861152 Thyroid-Stimulating Hormone Receptor (TSHR) Blockade With REGN24493 in Adult Participants… Phase 1 Not Yet Recruiting
2026-10-02 NCT07854782 Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic… Phase 3 Not Yet Recruiting
2026-09-30 NCT07850921 REGN21353 Alone or in Combination With Nezastomig for Metastatic Castration-Resistant… Phase 1/2 Not Yet Recruiting
2026-09-22 NCT07832370 A Trial of ALN-6457 in Adult Participants With Symptomatic Prion Disease (PrD) Phase 1/2 Not Yet Recruiting
2026-09-21 NCT07830329 Efficacy and Safety of Olatorepatide Versus Placebo in Adults With Moderate to Severe… Phase 2 Not Yet Recruiting

Active trials by phase

Phase 1
17
Phase 1/2
25
Phase 2
27
Phase 2/3
2
Phase 3
35
Phase 4
4
Not charted: 10 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 120

NCT IDTitleConditionStatusUpdated
Phase 4
NCT07609940 Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of… Relapsed/Refractory Multiple Myeloma (RRMM) Recruiting 2026-09-25
NCT07142343 A Study to Test the Safety of Pozelimab in Pediatric Participants 1 to 5 Years of Age… CHAPLE Disease Recruiting 2026-04-13
NCT06572228 Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting… Asthma Active, Not Recruiting 2026-05-22
NCT07587658 This After Market Study is Seeing if Dupilumab Plus Usual Standard of Care (SOC) is… Chronic Obstructive Pulmonary Disease (COPD) Not Yet Recruiting 2026-05-14
Phase 3
NCT07015905 REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee… Venous Thromboembolism (VTE) Recruiting 2026-10-08
NCT07213778 REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee… Symptomatic Venous Thromboembolism (VTE) Recruiting 2026-10-08
NCT07222761 A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination… Relapsed and/or Refractory Multiple Myeloma (RRMM) Recruiting 2026-10-08
NCT07626411 Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation Atrial Fibrillation (AF) Recruiting 2026-10-08
NCT05730036 A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab… Relapsed Refractory Multiple Myeloma (RRMM) Recruiting 2026-10-07
NCT06091865 A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it… Diffuse Large B-cell Lymphoma (DLBCL) Recruiting 2026-10-07
NCT06149286 A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better… Relapsed/Refractory Follicular Lymphoma Recruiting 2026-10-07
NCT06246916 A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants… Melanoma Recruiting 2026-10-07
NCT07393282 A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering… High Risk Smoldering Multiple Myeloma (HR-SMM) Recruiting 2026-10-07
NCT06091254 A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works… Follicular Lymphoma (FL) Recruiting 2026-10-06
NCT07112378 A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food… Eosinophilic Esophagitis (EoE) Recruiting 2026-09-29
NCT07410117 REGN7508 in Adult Participants for Prevention of Cancer-Associated Thrombosis Cancer-Associated Thrombosis (CAT) Recruiting 2026-09-29
NCT07697599 Venous Thromboembolism (VTE) Prophylaxis With REGN7508 and REGN9933 in Adult and… Venous Thromboembolism (VTE) Recruiting 2026-09-29
NCT05744921 A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How… Paroxysmal Nocturnal Hemoglobinuria Recruiting 2026-09-28
NCT07493304 Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants… Venous Thromboembolism (VTE) Recruiting 2026-09-28
NCT07318610 Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With… Peripheral Artery Disease (PAD) Recruiting 2026-09-25
NCT06541704 A Study Investigating Subcutaneously Administered Pozelimab in Combination With… Age-related Macular Degeneration (AMD) Recruiting 2026-09-18
NCT07430956 Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation… Atrial Fibrillation (AF) Recruiting 2026-09-17
NCT06585410 Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous… Cutaneous Squamous Cell Carcinoma (CSCC) Recruiting 2026-09-16
NCT07220785 Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized… Generalized Lipodystrophy Recruiting 2026-09-11
NCT07675811 A Study to Evaluate the Efficacy and Safety of Fel d 1 Monoclonal Antibodies in Adult and… Allergic Conjunctivitis Recruiting 2026-08-12
See all 120 active Regeneron Pharmaceuticals trials with filters →

Disease areas by active trials, top 10 of 31

Multiple Myeloma (11) · Non-Small Cell Lung Cancer (NSCLC) (10) · Lung Cancer (9) · Melanoma (6) · NASH / MASH (6) · Obesity (5) · Prostate Cancer (5) · Chronic Kidney Disease (4) · Non-Hodgkin Lymphoma (4) · Ovarian Cancer (4)

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