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NCT06230224 · ClinicalTrials.gov record · last posted 2026-05-11

A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma

Study acronym: OLYMPIA-4
StatusActive, Not Recruiting
PhasePhase 3
Started2024-02-15
View on ClinicalTrials.gov ↗
from the ClinicalTrials.gov record
This study is researching an experimental drug called odronextamab, referred to as study drug. The study is focused on patients with previously treated aggressive B-cell non-Hodgkin lymphoma whose cancer has stopped responding to treatment (also known as 'refractory') or has returned (also known as 'relapsed'). The aim of the study is to see how safe, tolerable and effective the study drug is when given alone. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug versus Standard of Care (SOC) * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects) * Comparing the impact from the study drug versus SOC on quality-of-life and ability to complete routine daily activities

Protocol amendment history 4 changes detected by DataLookout

2026-05-12
notable
Trial status changed: Recruiting → Active, Not Recruiting
2026-05-12
minor
Trial sites reduced: 101 → 81 locations
2026-05-12
critical
Primary completion pushed: 2027-05-14 → 2028-05-29
2026-05-12
minor
Completion pushed: 2027-05-14 → 2029-05-29
Trial Details
NCT Number NCT06230224
Lead Sponsor Regeneron Pharmaceuticals
Conditions B-Cell Non-Hodgkin Lymphoma (B-NHL)
Enrollment 216 participants
Start Date 2024-02-15
Primary Completion 2028-05-29 (estimated)
Study Completion 2029-05-29 (estimated)
Updated on ClinicalTrials.gov 2026-05-11