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Regeneron Pharmaceuticals clinical trial pipeline

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117 active trials 69 recruiting 36 Phase 3 31 disease areas 45 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-02

What changed in the last 30 days showing 35 of 45 changes on 20 trials

2026-10-02
Primary completion pushed: 2027-08-20 → 2028-01-28
Completion pushed: 2027-12-08 → 2028-05-17
NCT07235917 A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea · Phase 2
2026-09-25
Primary completion pushed: 2027-03-25 → 2028-11-08
Completion pushed: 2027-11-30 → 2028-11-08
NCT04590326 A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given… · Phase 1/2
2026-09-22
Primary completion pushed: 2027-01-06 → 2027-05-05
Completion pushed: 2027-01-06 → 2027-05-05
NCT05259709 A Study of ImmunoPet Imaging Using 89Zr-DFO-REGN5054 in Adult Participants With Solid… · Phase 1
2026-09-12
Primary completion pushed: 2027-09-24 → 2028-10-13
Enrollment reduced: 270 → 195 participants
Interventions modified
Completion pushed: 2028-04-07 → 2028-10-13
NCT07271186 Study to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney Disease · Phase 2
2026-09-19
Primary endpoint(s) modified
Results posted: 2026-09-18
NCT06491914 A Phase 3b, Single-Arm Study of Aflibercept 8 mg Dosed Every 4 Weeks in Adult… · Phase 3
2026-09-30
Recruitment opened
NCT07697599 Venous Thromboembolism (VTE) Prophylaxis With REGN7508 and REGN9933 in Adult and… · Phase 3
2026-10-01
Trial completed
NCT06669234 Phase 1 Safety and Tolerability Study of ALN-F1202 in Healthy Adults · Phase 1
2026-09-29
Recruitment opened
Primary completion pushed: 2029-07-25 → 2029-09-14
Completion pushed: 2029-10-16 → 2029-12-06
NCT07675824 REGN22530 for Adults With Primary Open Angle Glaucoma or Ocular Hypertension · Phase 1/2
2026-09-29
Trial completed
Final enrollment: 12343 participants (planned 3930)
Primary completion confirmed: April 2026 (last estimated January 2027)
NCT03936335 An Observational Retrospective Cohort Study Being Conducted in Women With Atopic…
2026-09-17
Enrollment closed, study ongoing
Trial sites reduced: 40 → 29 locations
Final enrollment: 95 participants (planned 231)
Primary completion moved earlier: 2032-04-22 → 2027-07-06
Completion moved earlier: 2032-04-22 → 2027-07-06
NCT04077099 A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor… · Phase 1/2
2026-09-30
Trial sites expanded: 24 → 28 locations
NCT07222761 A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination… · Phase 3
2026-09-29
Trial sites expanded: 6 → 12 locations
NCT07493304 Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants… · Phase 3
2026-09-30
Trial sites expanded: 5 → 18 locations
NCT07685808 Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without… · Phase 2
2026-09-30
Trial sites expanded: 6 → 9 locations
NCT07527910 A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With… · Phase 2
2026-09-29
Trial sites expanded: 81 → 84 locations
NCT07175428 Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation · Phase 2
2026-09-26
Trial sites expanded: 17 → 20 locations
NCT07318610 Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With… · Phase 3
2026-09-26
Trial sites expanded: 14 → 19 locations
NCT07393282 A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering… · Phase 3
2026-09-26
Trial sites expanded: 36 → 46 locations
NCT07213778 REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee… · Phase 3
2026-09-26
Trial sites expanded: 185 → 190 locations
NCT06091865 A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it… · Phase 3
2026-09-26
Trial sites expanded: 1 → 5 locations
NCT07527923 First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult… · Phase 1

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-09-30 NCT07850921 REGN21353 Alone or in Combination With Nezastomig for Metastatic Castration-Resistant… Phase 1/2 Not Yet Recruiting
2026-09-22 NCT07832370 A Trial of ALN-6457 in Adult Participants With Symptomatic Prion Disease (PrD) Phase 1/2 Not Yet Recruiting
2026-09-21 NCT07830329 Efficacy and Safety of Olatorepatide Versus Placebo in Adults With Moderate to Severe… Phase 2 Not Yet Recruiting
2026-09-09 NCT07808515 A Study Comparing Cemiplimab-based Treatments for Adult Participants With Locally… Phase 2 Not Yet Recruiting

Active trials by phase

Phase 1
16
Phase 1/2
24
Phase 2
27
Phase 2/3
2
Phase 3
34
Phase 4
4
Not charted: 10 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 117

NCT IDTitleConditionStatusUpdated
Phase 4
NCT07609940 Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of… Relapsed/Refractory Multiple Myeloma (RRMM) Recruiting 2026-09-25
NCT07142343 A Study to Test the Safety of Pozelimab in Pediatric Participants 1 to 5 Years of Age… CHAPLE Disease Recruiting 2026-04-13
NCT06572228 Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting… Asthma Active, Not Recruiting 2026-05-22
NCT07587658 This After Market Study is Seeing if Dupilumab Plus Usual Standard of Care (SOC) is… Chronic Obstructive Pulmonary Disease (COPD) Not Yet Recruiting 2026-05-14
Phase 3
NCT05730036 A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab… Relapsed Refractory Multiple Myeloma (RRMM) Recruiting 2026-09-30
NCT07112378 A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food… Eosinophilic Esophagitis (EoE) Recruiting 2026-09-29
NCT07222761 A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination… Relapsed and/or Refractory Multiple Myeloma (RRMM) Recruiting 2026-09-29
NCT07410117 REGN7508 in Adult Participants for Prevention of Cancer-Associated Thrombosis Cancer-Associated Thrombosis (CAT) Recruiting 2026-09-29
NCT07697599 Venous Thromboembolism (VTE) Prophylaxis With REGN7508 and REGN9933 in Adult and… Venous Thromboembolism (VTE) Recruiting 2026-09-29
NCT05744921 A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How… Paroxysmal Nocturnal Hemoglobinuria Recruiting 2026-09-28
NCT07015905 REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee… Venous Thromboembolism (VTE) Recruiting 2026-09-28
NCT07493304 Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants… Venous Thromboembolism (VTE) Recruiting 2026-09-28
NCT07626411 Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation Atrial Fibrillation (AF) Recruiting 2026-09-28
NCT06091865 A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it… Diffuse Large B-cell Lymphoma (DLBCL) Recruiting 2026-09-25
NCT06246916 A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants… Melanoma Recruiting 2026-09-25
NCT07213778 REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee… Symptomatic Venous Thromboembolism (VTE) Recruiting 2026-09-25
NCT07318610 Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With… Peripheral Artery Disease (PAD) Recruiting 2026-09-25
NCT07393282 A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering… High Risk Smoldering Multiple Myeloma (HR-SMM) Recruiting 2026-09-25
NCT06541704 A Study Investigating Subcutaneously Administered Pozelimab in Combination With… Age-related Macular Degeneration (AMD) Recruiting 2026-09-18
NCT07430956 Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation… Atrial Fibrillation (AF) Recruiting 2026-09-17
NCT06585410 Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous… Cutaneous Squamous Cell Carcinoma (CSCC) Recruiting 2026-09-16
NCT06091254 A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works… Follicular Lymphoma (FL) Recruiting 2026-09-11
NCT07220785 Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized… Generalized Lipodystrophy Recruiting 2026-09-11
NCT06149286 A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better… Relapsed/Refractory Follicular Lymphoma Recruiting 2026-08-14
NCT07675811 A Study to Evaluate the Efficacy and Safety of Fel d 1 Monoclonal Antibodies in Adult and… Allergic Conjunctivitis Recruiting 2026-08-12
See all 117 active Regeneron Pharmaceuticals trials with filters →

Disease areas by active trials, top 10 of 31

Multiple Myeloma (11) · Non-Small Cell Lung Cancer (NSCLC) (10) · Lung Cancer (9) · Melanoma (6) · NASH / MASH (5) · Obesity (5) · Prostate Cancer (5) · Chronic Kidney Disease (4) · Non-Hodgkin Lymphoma (4) · Ovarian Cancer (4)

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