Disease landscape

NASH / MASH clinical trials

Get alerts when NASH / MASH trials change

484 active trials 241 recruiting 23 Phase 3 316 sponsors 42 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 40 of 42 changes on 20 trials

2026-08-11
Primary completion pushed: 2026-08-31 → 2027-09-03
Completion pushed: 2026-10-02 → 2027-12-31
NCT03884075 Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect… · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Phase 2
2026-08-18
Primary completion pushed: 2027-03-25 → 2030-03-25
Completion moved earlier: 2032-03-25 → 2031-03-25
NCT05463796 InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer · Dana-Farber Cancer Institute
2026-08-14
Primary completion pushed: 2027-11-01 → 2028-11-01
Completion pushed: 2027-11-01 → 2028-11-01
NCT07216859 Screening Cardiometabolic Opportunities Using Transformative Echocardiography Artificial… · Kaiser Permanente
2026-08-13
Primary completion pushed: 2026-03-31 → 2026-07-01
Enrollment increased: 120 → 141 participants
NCT07007741 Digital Therapy for Fatty Liver Disease · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
2026-08-29
Enrollment reduced: 60 → 50 participants
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
Primary completion 2026-06-15, 350 days after the final estimate of 2025-06-30
Completion pushed: 2025-07-30 → 2026-12-31
NCT06373523 MASLD in Primary Hypothyroidism and Efficacy of Dapaglifozin · Post Graduate Institute of Medical Education and Research, Chandigarh · Early Phase 1
2026-08-18
Enrollment reduced: 20 → 16 participants
Trial completed
Primary completion pushed: 2026-05 → 2026-07-13
NCT07073326 Effects of Normobaric Hypoxic Training in Metabolic Dysfunction-Associated Steatotic… · University of Trieste
2026-08-18
Enrollment reduced: 4000 → 3000 participants
Trial sites expanded: 1 → 4 locations
Trial arms changed: 1 → 2
NCT07070362 Digital Early Warning System for Acute Lung Injury in Liver Surgery · Beijing Tsinghua Chang Gung Hospital
2026-08-13
Enrollment reduced: 45 → 20 participants
Trial completed
Primary completion moved earlier: 2026-05-31 → 2026-02-10
Completion moved earlier: 2026-07-15 → 2026-02-10
NCT04987879 NASH AMPK Exercise Dosing (AMPED) Trial · Milton S. Hershey Medical Center
2026-09-02
Recruitment opened
NCT07732400 A Study of VV-14303 for the Treatment of Metabolic Dysfunction-associated Steatohepatitis… · Kriya Therapeutics, Inc. · Phase 1/2
2026-09-03
Completed without a posted recruiting period
Study completion confirmed: June 2026 (last estimated December 2026)
NCT07331545 Safety, Tolerability, PK, PD, and Immunogenicity of QL2401 in Healthy Chinese Adults · Qilu Pharmaceutical Co., Ltd. · Phase 1
2026-08-27
Recruitment opened
NCT07660848 A Study of HRS-4729 Injection and HRS9531 Injection in Participants With Metabolic… · Fujian Shengdi Pharmaceutical Co., Ltd. · Phase 2
2026-08-27
Enrollment closed, study ongoing
NCT07488975 Developing Microbial Therapy for MASLD: From Mechanism to Clinical Validation · Leeuwenhoek Laboratories Co. Ltd. · Phase 1
2026-08-20
Trial completed
NCT04505436 Study to Evaluate Efficacy, Safety and Tolerability of HM15211(Efocipegtrutide) in… · Hanmi Pharmaceutical Company Limited · Phase 2
2026-09-01
Trial completed
Final enrollment: 31 participants (planned 55)
NCT05935826 Effect of Amino Acids on Hepatic Fat Content in Adolescents (AMINOS Study) · University of Colorado, Denver · Phase 3
2026-09-05
Trial completed
Primary completion 2026-06-30, at least 212 days after the final estimate of 2025-11-30
Final enrollment: 1762 participants (planned 3000)
NCT04999124 Characteristics of NAFLD Among Type 2 Diabetes Patients · Ziekenhuis Oost-Limburg
2026-09-03
Enrollment closed, study ongoing
Primary completion 2026-09-01, at least 212 days after the final estimate of 2026-02-01
NCT06879236 Secondary and Tertiary Digital Prevention of Non-alcoholic and Dysmetabolic Liver Disease · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
2026-09-03
Enrollment closed, study ongoing
NCT06888310 Optimizing Noninvasive assessMent Of DysmEtabolic Compensated Advanced Liver Disease · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
2026-09-05
Primary completion pushed: 2026-08 → 2026-10
Completion pushed: 2026-08 → 2026-10
NCT06934642 Effect of Tirzepatide on Markers of MASLD in Patients With Obesity · University of New Mexico · Early Phase 1
2026-08-11
Enrollment closed, study ongoing
NCT07466017 A Study of CS060380 Tablets in Patients With MASH and Obesity · Cascade Pharmaceuticals, Inc · Phase 2
2026-09-04
Trial sites expanded: 321 → 326 locations
NCT06419374 A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With… · 89bio, Inc. · Phase 3

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-03 NCT07801313 Phase 1 Clinical Study of MWN105 Injection in Healthy Chinese Volunteers Shanghai Minwei Biotechnology Co., Ltd new Phase 1
2026-08-20 NCT07775638 Detecting Liver Fibrosis in Patients At-risk Helse Stavanger HF new
2026-07-31 NCT07740109 The Effects of 5-methyltetrahydrofolate Supplementation in Patients With Metabolic… Tabriz University of Medical Sciences new
2026-07-30 NCT07737340 Metabolic Liver Disease in Newly Diagnosed People Living With HIV (MASHIV-TR) Yaşar Bayındır, MD new
2026-07-28 NCT07730853 Isocaloric Navy-Bean Substitution in Adults With MASLD Icahn School of Medicine at Mount Sinai new
2026-07-28 NCT07732400 A Study of VV-14303 for the Treatment of Metabolic Dysfunction-associated Steatohepatitis… Kriya Therapeutics, Inc. new Phase 1/2
2026-07-24 NCT07726368 Study of ECC4703 With Sulfasalazine and Pitavastatin Eccogene new Phase 1
2026-07-21 NCT07716384 Wearable Patch Ultrasound Probe for Diagnosis of Liver Stiffness Second Affiliated Hospital of Xi'an Jiaotong University new
2026-07-20 NCT07713992 Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate… Tianjin Medical University new
2026-07-09 NCT07692438 Taiwan Green Propolis for Blood Lipids and Body Fat in Patients With MASLD Taipei Medical University new

Active trials by phase

Early Phase 1
7
Phase 1
24
Phase 1/2
7
Phase 2
66
Phase 2/3
1
Phase 3
22
Phase 4
19
Not charted: 338 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 484

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05305287 Quantifying Hepatic Mitochondrial Fluxes in Humans The University of Texas Health Science Center at San Antonio Recruiting 2026-08-17
NCT06374875 Fibrosis Lessens After Metabolic Surgery The Cleveland Clinic Recruiting 2026-07-31
NCT07249788 Resmiterom Efficacy & Safety in Patients With MASH Nabiqasim Industries (Pvt) Ltd Recruiting 2025-12-03
NCT06449833 Effect of Henagliflozein on Hepatic Fat Content in Patients With T2DM and NAFLD Zhujiang Hospital Recruiting 2024-06-10
NCT06368882 Efficacy and Safety of Antiviral Therapy With Peg-interferon for Chronic Hepatitis B… First Affiliated Hospital of Wenzhou Medical University Recruiting 2024-04-16
NCT06523530 Effect of a GnRH Analog on Hepatic Steatosis Aristotle University Of Thessaloniki Active, Not Recruiting 2026-07-23
NCT07707778 Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed… National Taiwan University Clinical Trial Center Enrolling by Invitation 2026-07-20
NCT07680478 Nutrition Intervention Combined With Resmetirom for MASH City University of New York Not Yet Recruiting 2026-07-06
NCT07663643 Fuzheng Huayu Tablets for Metabolic Dysfunction-Associated Fatty Liver Cirrhosis… Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Not Yet Recruiting 2026-06-23
NCT07274644 Effects of iGlarLixi Versus iGlar on Liver Fat Content in Patients With Type 2 Diabetes… The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Active, Not Recruiting 2026-06-22
NCT06845345 Effect of an Early Time Restricted Eating Mediterranean Diet Compared to… Carmen Dietvorst Enrolling by Invitation 2026-04-21
NCT05195944 Semaglutide vs Sitagliptin University Health Network, Toronto Enrolling by Invitation 2026-04-06
NCT07289750 The Effect of Alogliptin Combined With Actoplus Met on Glucose and Lipid Metabolism and… The Fourth Affiliated Hospital of Zhejiang University School of Medicine Not Yet Recruiting 2026-03-24
NCT05147090 Effects of Empagliflozin on Fibrosis and Cirrhosis in Chronic Hepatitis B Patients The University of Hong Kong Active, Not Recruiting 2026-01-30
NCT07180745 Empagliflozin Versus Statins in Non-Alcoholic Fatty Liver Disease Badr University Not Yet Recruiting 2025-09-18
NCT07071636 Clinical Efficacy of Pegylated Interferon Alpha-2b Combined With Nucleos(t)Ide Analogues… Shenzhen Third People's Hospital Not Yet Recruiting 2025-07-17
NCT06918080 Hepatoprotective Measures for Children at High Risk of NAFLD Ain Shams University Active, Not Recruiting 2025-04-09
NCT06920316 Digital Diet and Exercise Intervention to Reduce Liver Fibrosis in Metabolic… St. George's Hospital, London Not Yet Recruiting 2025-04-09
NCT06762223 Henagliflozin on Liver Fibrosis in Patients with MASLD and T2DM Xiqiao Zhou Not Yet Recruiting 2025-01-07
Phase 3
NCT06318169 A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and… 89bio, Inc. Recruiting 2026-09-03
NCT06419374 A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With… 89bio, Inc. Recruiting 2026-09-03
NCT06632457 LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver… Boehringer Ingelheim Recruiting 2026-09-03
NCT07795164 Phase 3 Study of the Efficacy, Safety, and Clinical Outcomes of Pemvidutide in MASH Altimmune, Inc. Recruiting 2026-08-31
NCT06632444 LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called… Boehringer Ingelheim Recruiting 2026-08-21
NCT07165028 A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated… Eli Lilly and Company Recruiting 2026-08-21
See all 484 active NASH / MASH trials with filters →

Top sponsors by active trials in this area

Assiut University (14) · Beijing Friendship Hospital (8) · GlaxoSmithKline (8) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (7) · Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis (6) · Cairo University (6) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (6) · Madrigal Pharmaceuticals, Inc. (6) · Tanta University (6) · Chinese University of Hong Kong (5)

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