How Abnormal Function of Fat Tissue in Type 1 Diabetes Contributes to Fat in the Liver

Steatotic liver disease associated with metabolic dysfunction (MASLD) is a disease caused by excess fat storage in the liver. Excessive fat delivery to the liver and MASLD typically occurs in people with abdominal obesity and type 2 diabetes. Type 1 diabetes (T1D) is also associated with a marked increase in the release of fat from adipose tissues and MASLD is increased in T1D and significantly increases the risk of heart, kidney and eye diseases.

NCT Number	NCT07133854
Lead Sponsor	Université de Sherbrooke Collaborators: Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Conditions	Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH), Type 1 Diabetes Mellitus
Enrollment	32 participants
Start Date	2026-09
Primary Completion	2027-09 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2025-08-21