Sponsor pipeline

Johnson & Johnson / Janssen clinical trial pipeline

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206 active trials 97 recruiting 78 Phase 3 30 disease areas 65 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-11

What changed in the last 30 days

48 trials changed in the last 30 days: 1 stopped, 10 with notable changes, 37 with minor changes only.

  1. Stopped

    Anti-mycobacterial Activity of TMC207 in Combination With Background Regimen (BR) of Multidrug Resistant Tuberculosis (MDR-TB) Medications · Children/Adolescents With Pulmonary MDR-TB

    Recruitment suspended

    Sponsor's reason: As part of the protocol-specified interim pharmacokinetic (PK) evaluation in Study TMC207-C211, PK data demonstrated lower-than-anticipated bedaquiline exposure

    Janssen Research & Development, LLCPhase 2 NCT02354014 Registry history of NCT02354014 on ClinicalTrials.gov (opens the registry)

    Updated

  2. Notable

    TRIlogy-7 · Ramantamig Plus Daratumumab Versus Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd) or Daratumumab, Lenalidomide, and Dexamethasone (DRd) · NDMM For Whom Stem Cell Transplant is Not Planned

    Recruitment opened

    Also in this update: Trial sites expanded: 0 → 19 locations; and 1 more change in the last 30 days

    Janssen Research & Development, LLCPhase 3 NCT07665450 Registry history of NCT07665450 on ClinicalTrials.gov (opens the registry)

    Updated

  3. Notable

    Vaccination With 9-valent Extraintestinal Pathogenic Escherichia Coli Vaccine (ExPEC9V) · Invasive Extraintestinal Pathogenic Escherichia Coli Disease in Adults Aged 60 Years And Older With a History of Urinary Tract Infection in the Past 2 Years

    Results posted: Sep 28, 2026

    Janssen Research & Development, LLCPhase 3 NCT04899336 Registry history of NCT04899336 on ClinicalTrials.gov (opens the registry)

    Updated

Show 37 trials with minor changes only
  1. Minor

    JNJ-79635322 in Combination With Daratumumab With or Without Lenalidomide for Multiple Myeloma, Newly Diagnosed AL Amyloidosis, and High-risk Smoldering Multiple Myeloma or JNJ-79635322 in Combination With Pomalidomide for Multiple Myeloma

    Enrollment increased: 240 → 276 participants

    And 2 more changes in the last 30 days

    Janssen Research & Development, LLCPhase 1 NCT06768489 Registry history of NCT06768489 on ClinicalTrials.gov (opens the registry)

    Updated

  2. Minor

    MajesTEC-3 · Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) · Relapsed or Refractory Multiple Myeloma

    Primary completion moved earlier from Sep 15, 2025 to Aug 1, 2025

    Janssen Research & Development, LLCPhase 3 NCT05083169 Registry history of NCT05083169 on ClinicalTrials.gov (opens the registry)

    Updated

  3. Minor

    MARIPOSA-2 · Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy · Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure

    Completion pushed from Nov 30, 2027 to Jul 3, 2028

    Janssen Research & Development, LLCPhase 3 NCT04988295 Registry history of NCT04988295 on ClinicalTrials.gov (opens the registry)

    Updated

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-10-01 NCT07851207 A Study to Assess Guselkumab in Participants With Moderate-to-Severe Inflammatory Bowel… Not Yet Recruiting
2026-09-21 NCT07832292 A Study of JNJ-101556143 in Participants With Metastatic Prostate Cancer Phase 2 Recruiting
2026-09-16 NCT07822529 A Study of Long Term Persistency of Guselkumab in Adult Participants With Inflammatory… Recruiting
2026-09-14 NCT07819305 Evaluation of Approved Contact Lenses (CR-6657) Recruiting

Active trials by phase

Phase 1
47
Phase 1/2
12
Phase 2
30
Phase 2/3
7
Phase 3
71
Phase 4
6
Not charted: 33 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 206

NCT IDTitleConditionStatusUpdated
Phase 4
NCT07654751 A Remotely Conducted Study to Assess Concentration of TREMFYA in Breast Milk of Lactating… Psoriasis Recruiting 2026-10-05
NCT05201781 A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel Multiple Myeloma Recruiting 2026-09-25
NCT07310095 A Study to Evaluate the Efficacy of Guselkumab in Chinese Participants With Crohn's… Crohn Disease Recruiting 2026-09-25
NCT07141004 A Study of Guselkumab Administered Subcutaneously in Treatment of Indian Participants… Arthritis, Psoriatic Recruiting 2026-08-28
NCT04929210 A Study of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active… Arthritis, Psoriatic Active, Not Recruiting 2026-09-25
NCT07030517 A Study to Assess Safety of Teclistamab in Indian Participants With Relapsed and… Multiple Myeloma Active, Not Recruiting 2026-09-25
Phase 3
NCT07665450 A Study of Ramantamig Plus Daratumumab Versus Daratumumab, Bortezomib, Lenalidomide, and… Multiple Myeloma Recruiting 2026-10-06
NCT07573176 A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major… Depressive Disorder, Major Recruiting 2026-10-01
NCT06919965 A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants… Non-Muscle Invasive Bladder Neoplasms Recruiting 2026-09-28
NCT04892173 JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC Carcinoma, Squamous Cell Recruiting 2026-09-25
NCT05552222 A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and… Multiple Myeloma Recruiting 2026-09-25
NCT05912517 A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus… Hemolytic Disease of the Fetus and Newborn Recruiting 2026-09-25
NCT05923073 A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active… Crohn's Disease Recruiting 2026-09-25
NCT06319820 A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in… Non-Muscle Invasive Bladder Neoplasms Recruiting 2026-09-25
NCT06449651 A Study of Nipocalimab in Reducing the Risk of Fetal and Neonatal Alloimmune… Thrombocytopenia, Neonatal Alloimmune Recruiting 2026-09-25
NCT06533098 A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of… Thrombocytopenia, Neonatal Alloimmune Recruiting 2026-09-25
NCT06559306 Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants… Depressive Disorder, Major Recruiting 2026-09-25
NCT06662786 A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI… Colorectal Neoplasms Recruiting 2026-09-25
NCT06663332 A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants Crohns Disease Recruiting 2026-09-25
NCT06750094 A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in… Colorectal Neoplasms Recruiting 2026-09-25
NCT06807424 A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in… Arthritis, Psoriatic Recruiting 2026-09-25
NCT06852222 A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With… Leukemia, Myeloid, Acute Recruiting 2026-09-25
NCT07164443 A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line… Metastatic Castration-resistant Prostatic Neoplasms Recruiting 2026-09-25
NCT07196748 A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to… Colitis, Ulcerative Recruiting 2026-09-25
NCT07217587 Comparative Efficacy of Nipocalimab and Efgartigimod in Participants With Generalized… Myasthenia Gravis Recruiting 2026-09-25

Disease areas by active trials, top 10 of 30

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