A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

The purpose of this protocol is to evaluate the efficacy (how well it works), safety and tolerability of oral icotrokinra as therapy in adult and adolescent participants with moderately to severely active ulcerative colitis (UC, a chronic disease of the large intestine in which the lining of the colon becomes inflamed and develops tiny open ulcers).

NCT Number	NCT07196748
Lead Sponsor	Janssen Research & Development, LLC
Conditions	Colitis, Ulcerative
Enrollment	882 participants
Start Date	2025-10-01
Primary Completion	2028-01-14 (estimated)
Study Completion	2032-01-13 (estimated)
Updated on ClinicalTrials.gov	2026-07-31