Clinical Trial

A Study of Ramantamig Plus Daratumumab Versus Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd) or Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With NDMM For Whom Stem Cell Transplant is Not Planned

Study acronym: TRIlogy-7
Not Yet Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
The main purpose of this study is to see how well a new treatment ramantamig-D works compared to standard treatments that is either DVRd or DRd on progression-free survival (PFS; time until a participant's disease worsens) and 12-month minimal residue disease (MRD)-negative complete response (CR) rate (percentage of participants in whom cancer cells are not detected) in participants with newly diagnosed multiple myeloma (NDMM; an initial stage of blood cancer that forms in a type of white blood cells \[WBCs\] called plasma cells) for whom stem cell transplant is not planned as initial therapy.
Trial Details
NCT Number NCT07665450
Lead Sponsor Janssen Research & Development, LLC
Conditions Multiple Myeloma
Enrollment 1,000 participants
Start Date 2026-09-14
Primary Completion 2030-09-04 (estimated)
Study Completion 2035-02-02 (estimated)
Updated on ClinicalTrials.gov 2026-07-06