Disease landscape

Crohn's Disease clinical trials

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493 active trials 306 recruiting 48 Phase 3 261 sponsors 64 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 34 of 64 changes on 20 trials

2026-09-02
Primary completion pushed: 2025-10-01 → 2027-09-01
Completion pushed: 2026-03-01 → 2027-12-01
NCT05659953 LMT503 First-in-human SAD, MAD, and FE Study · Lmito Therapeutics Inc. · Phase 1
2026-08-28
Primary completion pushed: 2026-09-18 → 2027-02-17
NCT06233461 A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of… · Takeda · Phase 2
2026-08-08
Primary completion pushed: 2026-05 → 2029-02
Completion pushed: 2026-05 → 2029-02
NCT03105102 A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease · AbbVie · Phase 3
2026-09-05
Primary completion pushed: 2026-10-01 → 2026-12-31
Recruitment opened
Completion pushed: 2026-10-31 → 2027-02-01
NCT07263880 Clostridium Butyricum in Stenosing Crohn's Disease · San Giovanni Addolorata Hospital · Phase 1/2
2026-08-21
Primary completion pushed: 2026-03-31 → 2026-12-31
Completion pushed: 2026-03-31 → 2026-12-31
NCT05316584 A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and… · University of Maryland, Baltimore
2026-08-12
Primary completion pushed: 2027-12-31 → 2030-12-31
Sponsor changed: PIBD-Net → Erasmus Medical Center
Completion pushed: 2027-12-31 → 2030-12-31
NCT03571373 PIBD-SETQuality: the Inception Cohort and Safety Registry · Erasmus Medical Center
2026-08-08
Primary completion pushed: 2028-03-01 → 2028-08-01
Enrollment reduced: 250 → 216 participants
Sponsor changed: University of California, San Diego → Mayo Clinic
Completion pushed: 2028-06-01 → 2029-02-01
NCT05230173 Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission · Mayo Clinic
2026-08-08
Primary endpoint(s) modified
NCT06430801 A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants… · Merck Sharp & Dohme LLC · Phase 3
2026-09-01
Enrollment reduced: 100 → 50 participants
NCT06045754 A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in… · Takeda · Phase 4
2026-08-28
Enrollment reduced: 44 → 22 participants
Primary completion pushed: 2028-06 → 2028-08
NCT07680283 Ultrasound-Guided Versus Standard Margin Selection in Ileocecal Resection of Terminal… · The Cleveland Clinic
2026-09-05
Recruitment opened
Primary completion moved earlier: 2026-12-31 → 2026-09-26
Completion moved earlier: 2026-12-31 → 2026-09-26
NCT07672574 Human Mass Balance Study of [14C] Ontunisertib in Healthy Volunteers · Agomab Spain S.L.U. · Phase 1
2026-09-02
Recruitment opened
NCT07625293 DB-3Q for the Treatment of Medically Refractory Crohn's Disease · Direct Biologics, LLC · Phase 2
2026-08-29
Recruitment opened
NCT07654751 A Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are… · Janssen Research & Development, LLC · Phase 4
2026-08-29
Recruitment opened
Trial sites reduced: 30 → 21 locations
NCT07697456 Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to… · AbbVie · Phase 2
2026-08-25
Recruitment opened
NCT07683325 NOV-ERA - A Clinical Trial to Assess the Efficacy and Safety of Ontunisertib Compared to… · Agomab Spain S.L.U. · Phase 2
2026-08-25
Recruitment opened
NCT07403968 A Study of Zasocitinib (TAK-279) in Adults With Active Crohn's Disease · Takeda · Phase 2
2026-09-04
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
NCT07484620 Physical Activity and Fitness in Pediatric Inflammatory Bowel Disease · Universidad Complutense de Madrid
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07416383 Safety and Efficiency of the Universal CNK-UT009 in Difficult-to-treat Inflammatory Bowel… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 1
2026-08-08
Trial completed
NCT05626088 A Study in Adults With Inflammatory Bowel Disease (IBD) Receiving Vedolizumab in the… · Takeda
2026-08-18
Enrolling by invitation only
NCT07686757 INSIGHT-IBD Pragmatic Study · Specialty Networks Research. · Phase 4

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-02 NCT07799506 Accurately Profiling the Changes and Functions of Key Microflora in the Whole Intestinal… Changhai Hospital new
2026-09-02 NCT07799428 Bacillus Probiotic Spores in Supporting the Treatment of Chronic Inflammatory Bowel… Anabio R&D new
2026-09-01 NCT07796568 Virtual Group Therapy for IBD Patients With Anxiety and Depression University of Chicago new
2026-08-31 NCT07795476 Artificial Intelligence For Outcomes Research in Crohn's Disease: Digital Pathology… PharmaNest, Inc new
2026-08-28 NCT07791888 R-3750 in Patients With Crohn's Disease Rise Therapeutics LLC new Phase 1
2026-08-26 NCT07788131 Inflammatory Biomarkers and Disease Activity in Inflammatory Bowel Disease Assiut University new
2026-08-25 NCT07784114 Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic… Beijing University of Chinese Medicine new
2026-08-18 NCT07769437 Non-nutritive Sweeteners in Inflammatory Bowel Disease University Hospitals Cleveland Medical Center new
2026-08-18 NCT07770425 Lesion Size Measurement During Gastrointestinal Endoscopies Centre hospitalier de l'Université de Montréal (CHUM) new
2026-08-14 NCT07766733 The Safety and Efficacy of Good Feeling Power® for IBD Patients Good Feeling Products GmbH new

Active trials by phase

Early Phase 1
8
Phase 1
13
Phase 1/2
15
Phase 2
41
Phase 2/3
5
Phase 3
43
Phase 4
39
Not charted: 329 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 493

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06045754 A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in… Takeda Recruiting 2026-08-31
NCT07654751 A Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are… Janssen Research & Development, LLC Recruiting 2026-08-28
NCT07310095 A Study to Evaluate the Efficacy of Guselkumab in Chinese Participants With Crohn's… Xian-Janssen Pharmaceutical Ltd. Recruiting 2026-08-27
NCT06581328 A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the… Takeda Recruiting 2026-08-14
NCT06997965 Open-label Single-arm Study to Assess the Efficacy of Mirikizumab in Patients With… Alimentiv Inc. Recruiting 2026-07-16
NCT07691138 Stopping PPI Therapy in Inactive IBD University of Nottingham Recruiting 2026-07-08
NCT07616687 Optimal Care With Guselkumab in Crohn's Disease / OPTIM Study A Prospective Open Label… Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives Recruiting 2026-06-30
NCT07510191 TNFi Plus Low-Dose Upadacitinib vs TNFi Intensification in Crohn's Disease With… Sixth Affiliated Hospital, Sun Yat-sen University Recruiting 2026-06-09
NCT05781152 Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's… Connecticut Children's Medical Center Recruiting 2026-05-27
NCT07292012 Efficacy of MIrikizumab to Achieve Transmural Healing in patiENTs With Crohn's Disease Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives Recruiting 2026-05-26
NCT05169593 Prevention of Postoperative Endoscopic Recurrence With Endoscopy-driven Versus Systematic… Universitaire Ziekenhuizen KU Leuven Recruiting 2026-05-05
NCT06180382 Comparison of Vedolizumab Treatment to Adalimumab Dose Intensification in Crohn's Disease… Centre Hospitalier Universitaire de Saint Etienne Recruiting 2026-05-05
NCT07216014 Interleukin-23 Monoclonal Antibody for Inflammatory Bowel Disease: Efficacy and Safety Sixth Affiliated Hospital, Sun Yat-sen University Recruiting 2026-04-24
NCT06774079 Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) and Diet in Inflammatory Bowel… University of Miami Recruiting 2026-03-30
NCT05043870 Combined Immunosuppression for Pediatric Crohn's Disease Children's Hospital of Fudan University Recruiting 2026-03-19
NCT06520397 Efficacy and Safety of Dual-targeted Therapy With Upadacitinib and Ustekinumab Versus… Sixth Affiliated Hospital, Sun Yat-sen University Recruiting 2026-02-23
NCT06257706 VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease Alimentiv Inc. Recruiting 2026-01-15
NCT07303686 De-escalation of Ustekinumab Therapy in Patients With Crohn's Disease and Ulcerative… McGill University Health Centre/Research Institute of the McGill University Health Centre Recruiting 2025-12-26
NCT05928039 PATHFINDER: Evaluating the Optimal First-Line Treatment Strategy for Moderate-to-Severely… University of Calgary Recruiting 2025-06-11
NCT05906576 Post-marketing Registry Study of Infliximab for Injection in Chinese Pediatric Crohn's… Taizhou Mabtech Pharmaceutical Co.,Ltd Recruiting 2025-05-22
NCT06298461 Bowel Preparation for Colonoscopy Among Individuals With Crohn's and Ulcerative Colitis… University of Manitoba Recruiting 2025-01-08
NCT05552287 Pharmacokinetic Infliximab Data in Pediatric Crohn's Disease Erasmus Medical Center Recruiting 2024-09-19
NCT06113913 Subcutaneous Infliximab After A Previous Intravenous Dose Optimization Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW Recruiting 2024-07-26
NCT06051253 TDM-based Infliximab Treatment for Active Perianal Fistulizing Crohn's Disease Asan Medical Center Recruiting 2024-05-14
NCT03917303 Control Crohn Safe Trial Maastricht University Medical Center Recruiting 2022-09-07
See all 493 active Crohn's Disease trials with filters →

Top sponsors by active trials in this area

AbbVie (16) · Takeda (16) · Sixth Affiliated Hospital, Sun Yat-sen University (13) · Janssen Research & Development, LLC (11) · Second Affiliated Hospital, School of Medicine, Zhejiang University (10) · Massachusetts General Hospital (9) · Assistance Publique - Hôpitaux de Paris (7) · Central Hospital, Nancy, France (7) · Alimentiv Inc. (6) · Asian Institute of Gastroenterology, India (6)

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