Sponsor pipeline

Bristol-Myers Squibb clinical trial pipeline

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Data updated daily from ClinicalTrials.gov, last refresh 2026-10-20

What changed in the last 30 days

33 trials changed in the last 30 days: 1 stopped, 8 with notable changes, 24 with minor changes only.

  1. Stopped

    BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax · Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

    Trial terminated

    Also in this update: Trial sites reduced: 16 → 10 locations; Primary completion date changed from estimate of Feb 1, 2027 to Aug 28, 2026

    Bristol-Myers SquibbPhase 1 NCT06419634 Registry history of NCT06419634 on ClinicalTrials.gov (opens the registry)

  2. Notable

    Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)

    Recruitment opened

    Also in this update: Trial sites reduced: 208 → 201 locations

    Bristol-Myers SquibbPhase 3 NCT07680790 Registry history of NCT07680790 on ClinicalTrials.gov (opens the registry)

  3. Notable

    Drug Levels, Absolute Bioavailability, Safety, Tolerability, and Immunogenicity of Single-Dose of BMS-986446 in Healthy Adults After Single-dose Administration, and · Early Alzheimer's Disease After Multiple Dose Administration

    Recruitment opened

    Also in this update: Trial sites expanded: 1 → 6 locations

    Bristol-Myers SquibbPhase 1 NCT07780383 Registry history of NCT07780383 on ClinicalTrials.gov (opens the registry)

Show 24 trials with minor changes only
  1. Minor

    SUCCESSOR-2 · Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) · Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)

    Primary completion pushed from Jul 18, 2026 to Sep 28, 2026

    Also in this update: Trial sites reduced: 207 → 204 locations

    Bristol-Myers SquibbPhase 3 NCT05552976 Registry history of NCT05552976 on ClinicalTrials.gov (opens the registry)

  2. Minor

    BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy · Extensive-Stage Small Cell Lung Cancer (TIGOS)

    Study completion moved earlier from Sep 5, 2031 to Jul 14, 2031

    Also in this update: Primary completion moved earlier from Apr 6, 2028 to Aug 17, 2027

    Bristol-Myers SquibbPhase 3 NCT06646276 Registry history of NCT06646276 on ClinicalTrials.gov (opens the registry)

  3. Minor

    Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment · Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

    Interventions modified

    Also in this update: Start date changed from estimate of Aug 31, 2026 to Sep 10, 2026

    Bristol-Myers SquibbPhase 2 NCT07680764 Registry history of NCT07680764 on ClinicalTrials.gov (opens the registry)

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-10-14 NCT07873931 A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases Phase 1 Not Yet Recruiting
2026-10-13 NCT07871214 A Study to Assess The Safety and Tolerability of Pumitamig-Based Therapy Administered… Phase 2 Not Yet Recruiting
2026-10-01 NCT07852884 First-Line Systemic Therapies in Advanced Renal Cell Carcinoma in Spain Active, Not Recruiting
2026-10-01 NCT07852962 Study to Assess Drug Levels, Immune Response, Safety and Tolerability of BMS-986446 in… Phase 1 Not Yet Recruiting
2026-09-30 NCT07848295 A Study to Assess the Safety and Tolerability of BMS-986527 in Participants With Clear… Phase 1 Not Yet Recruiting
2026-09-29 NCT07846059 Evaluation of Mavacamten-Based Practice in Chinese Adults With Obstructive Hypertrophic… Not Yet Recruiting
2026-09-23 NCT07837115 A Study to Assess the Relative Bioavailability of Irafamdastat (BMS-986368) and to Assess… Phase 1 Not Yet Recruiting

Active trials by phase

Phase 1
34
Phase 1/2
23
Phase 2
24
Phase 2/3
11
Phase 3
66
Phase 4
8
Not charted: 70 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Disease areas by active trials, top 10 of 49

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