Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT05552976 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)

Study acronym: SUCCESSOR-2
StatusActive, Not Recruiting
PhasePhase 3
Started2023-01-10
View on ClinicalTrials.gov ↗
Record status
This record was last updated September 24, 2026 (before its estimated September 28, 2026 completion). Its status may not reflect the trial's current state.
Trial flagged as At Risk
Primary completion moved at least 2 months later Jul 18, 2026 → Sep 28, 2026
See other at-risk trials from Bristol-Myers Squibb

Amendment history

The 49 most recent of 162 record versions are listed below. See every version on ClinicalTrials.gov ↗

2026-09-25
Trial sites reduced: 207 → 204 locations
Primary completion pushed: 2026-07-18 → 2026-09-28
2026-03-30
Study Status, Study Design v161
Enrollment increased: 525 → 606 participants
2026-03-16
Study Status v160
Primary completion date2026-02-04→2026-07-18
2026-02-09
Recruiting→Active, Not Recruiting Study Status, Contacts/Locations, IPDSharing v159
Trial statusRecruiting→Active, Not Recruiting
Study sites217→207
2026-01-12
Study Status, Contacts/Locations v158
Study sites217 entries, revised
AcibademLocal CityInstitution Clinic- University0309 Local MultiprofileInstitution Hospital- for0113 Local ActiveInstitution Treatment- Tokuda EAD Amphia Ziekenhuis, locatie Breda Molengracht Medisch Spectrum Twente0194
Show 45 earlier versions
2026-01-02
Study Status, Contacts/Locations v157
Study sites217 entries, revised
UniversitaetsklinikumLocal UlmInstitution - 0124 HaematologieLocal undInstitution Onkologie- Muenchen0330 Local Institution -Pasing 0333 KlinikumLocal NuernbergInstitution Nord,- Urologische0335 Local KlinikInstitution - 0029 PraxisLocal OnkologieInstitution am- Raschplatz0331 GEFOSLocal GesellschaftInstitution f.- onkologische0007 Local StudienInstitution - 0329 UniversitaetsklinikumLocal SchleswigInstitution -Holstein Campus0334 Local KielInstitution - 0015 UniversitätsklinikumLocal JenaInstitution - 0030 ChariteLocal UniversitätsmedizinInstitution Berlin- Campus0133 Local BenjaminInstitutio [...] [...]
2025-12-09
Study Status, Contacts/Locations v156
Study sites217 entries, revised
UniversityLocal Hospital,KyotoInstitution Prefectural- University of Medicine0216
2025-12-04
Study Status, Contacts/Locations v155
Study sitesdetails revised at 3 of 217 sites
2025-12-02
Study Status, Contacts/Locations v154
Study sitesdetails revised at 1 of 217 sites
2025-11-24
Study Status, Contacts/Locations v153
Study sitesdetails revised at 3 of 217 sites
2025-11-12
Study Status, Contacts/Locations v152
Study sites217 entries, revised
USALocal Mitchell Cancer Institute TOI Clinical Research Kaiser PermanenteInstitution - Irvine0046 LosLocal Angeles Hematology Oncology Medical Group Florida Cancer SpecialistsInstitution - South0005 EmoryLocal University School of Medicine- Grady Campus Winship Cancer Institute, Emory University Dana-Farber Cancer Institute Minnesota Oncology Hematology, P.A. Regional Cancer Care Associates University Hospitals Cleveland Medical Center Riverside Methodist Hospital Lifespan Cancer Institute Gibbs Cancer Ce [...] Institution - Marshfield0190 Local Institution - 0187 Local Institution - 0341 Local Inst [...]
2025-11-04
Study Status, Contacts/Locations v151
Study sitesdetails revised at 1 of 217 sites
2025-10-31
Study Status, Contacts/Locations v150
Study sitesdetails revised at 3 of 217 sites
2025-10-09
Study Status, Contacts/Locations v149
Study sitesdetails revised at 1 of 217 sites
2025-10-06
Study Status, Contacts/Locations v148
Study sitesdetails revised at 1 of 217 sites
2025-09-25
Study Status, Contacts/Locations v147
Study sites217 entries, revised
LocalUSA InstitutionMitchell Cancer Institute TOI Clinical Research Kaiser Permanente - 0046Irvine LocalLos InstitutionAngeles Hematology Oncology Medical Group Florida Cancer Specialists - 0005South LocalEmory InstitutionUniversity School of Medicine- Grady Campus Winship Cancer Institute, Emory University Dana-Farber Cancer Institute Minnesota Oncology Hematology, P.A. Regional Cancer Care Associates University Hospitals Cleveland Medical Center Riverside Methodist Hospital Lifespan Cancer Institute Gibbs Cancer Ce [...] - 0190 Local Institution - 0187 Local Institution - 0341 Local Institution - [...] [...]
2025-08-26
Study Status, Contacts/Locations v146
Study sitesdetails revised at 5 of 217 sites
2025-07-31
Study Status, Contacts/Locations v145
Study sitesdetails revised at 7 of 217 sites
2025-07-22
Study Status, Contacts/Locations v144
Study sites217 entries, revised
USA Mitchell Cancer Institute TOI Clinical Research Kaiser Permanente - Irvine Los Angeles Hematology Oncology Medical Group Sutter Santa Rosa Stockton Hematology Oncology Group Florida Cancer Specialists - South Florida Cancer Specialists - North Florida Cancer Specialists - East Emory University S [...] Local Institution - 0046 Local Institution - 0005 Local Institution - 0190 Local Institution - 0187 Local Institution - 0344 Local Institution - 0339 Local Institution - 0341 Local Institution - 0342 Local Institution - 0340 Local Institution - 0348 Local Institution - 0291 Local Institution - 0289 [...]
2025-05-28
Study Status, Contacts/Locations v143
Study sites217 entries, revised
LocalGibbs InstitutionCancer -Center 0338& Research Institute Tennessee Oncology Chattanooga Local Institution - 0349 Cancer Institute (WIA)0174
2025-04-29
Study Status, Contacts/Locations v142
Study sites217 entries, revised
LocalTennessee InstitutionOncology Marshfield Medical Center - 0323 Local Institution - 0336Marshfield
2025-04-22
Study Status, Contacts/Locations v141
Study sites217 entries, revised
LocalSutter InstitutionSanta - 0344Rosa
2025-04-01
Study Status, Contacts/Locations v140
Study sites217 entries, revised
LocalFlorida InstitutionCancer Specialists - 0341South LocalCentro Institutionde -Educación 0150Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) LocalHunan InstitutionCancer -Hospital Ruijin 0103Hospital Shanghai Jiaotong University School of Medicine LocalVejle Institution - 0118 Local Institution - 0125Sygehus Klinikum NürnbergNuernberg Nord, Urologische Klinik LocalCancer InstitutionInstitute - 0174(WIA) Institut CatalàCatalan d' Oncologia (ICO) - Badalona
2025-03-24
Study Status, Contacts/Locations v139
Study sites217 entries, revised
LocalFlorida InstitutionCancer Specialists - 0342North LocalFlorida InstitutionCancer Specialists - 0340East
2025-03-20
Study Status, Contacts/Locations v138
Study sites217 entries, revised
LocalLifespan InstitutionCancer - 0321Institute
2025-03-10
Study Status, Contacts/Locations v137
Study sites217 entries, revised
LocalMinnesota InstitutionOncology -Hematology, 0346P.A. LocalVirginia InstitutionOncology -Associates Shanxi 0345Bethune Hospital LocalSamsung InstitutionMedical - 0059 Local Institution - 0239Center
2025-02-25
Study Status, Contacts/Locations v136
Study sites217 entries, revised
LocalNorthwest InstitutionCancer -Specialists, 0347P.C. LocalNational InstitutionCheng -Kung 0002University Hospital
2025-02-06
Study Status, Contacts/Locations, References v135
Study sites217 entries, revised
Baylor Scott & White Medical Center - Temple Local Institution - 03430195 Blue Ridge Cancer Care
2025-01-27
Study Status, Contacts/Locations v134
Study sites216→217
2025-01-16
Study Status, Contacts/Locations v133
Study sites216 entries, revised
LocalJohn InstitutionPeter -Smith 0337Hospital LocalUMHAT Institution'Sveti -Ivan 0304Rilsky'
2025-01-09
Study Status, Contacts/Locations v132
Study sites216 entries, revised
LocalAcibadem InstitutionCity -Clinic 0309University Multiprofile Hospital for Active Treatment Tokuda EAD LocalUniversitaetsklinikum InstitutionCarl -Gustav 0329Carus Dresden
2025-01-06
Study Status, Contacts/Locations v131
Study sites216 entries, revised
LocalEmory InstitutionUniversity School of Medicine- 0348Grady Campus LocalGEFOS InstitutionGesellschaft -f. 0335onkologische Studien LocalNihon InstitutionUniversity -Itabashi 0236Hospital
2024-12-16
Study Status, Contacts/Locations v130
Study sites215→216
2024-12-09
Study Status, Contacts/Locations v129
Study sites215 entries, revised
LocalHaematologie Institutionund Onkologie Muenchen-Pasing Praxis 0330Onkologie am Raschplatz LocalMarien InstitutionHospital - 0333 Local Institution - 0334Düsseldorf
2024-12-02
Study Status, Contacts/Locations v128
Study sites213→215
2024-11-19
Study Status, Contacts/Locations, References v127
Study sites212→213
2024-11-11
Study Status, Contacts/Locations v126
Study sitesdetails revised at 1 of 212 sites
2024-11-06
Study Status, Contacts/Locations v125
Study sites206→212
2024-10-30
Study Status, Contacts/Locations v124
Study sites206 entries, revised
LocalUniversity InstitutionMultiprofile -Hospital 0305for Active Treatment "Sveti Georgi" EAD LocalSc InstitutionOnco -Card 0284Srl
2024-10-22
Study Status, Contacts/Locations v123
Study sites205→206
2024-10-15
Study Status, Contacts/Locations v122
Study sites205 entries, revised
Xi'anLocal InternationalInstitution Medical- Center Hospital0060
2024-10-04
Study Status, Contacts/Locations v121
Study sites204→205
2024-09-20
Study Status, Contacts/Locations v120
Study sites204 entries, revised
LocalSpitalul InstitutionClinic -Județean 0306de Urgență Sibiu
2024-09-12
Study Status, Contacts/Locations v119
Study sites204 entries, revised
LocalFundeni InstitutionClinical - 0282Institute LocalSpitalul InstitutionClinic - 0287Colțea
2024-09-10
Study Status, Contacts/Locations v118
Study sites203→204
2024-08-30
Study Status, Contacts/Locations v117
Study sites201→203
2024-08-23
Study Status, Contacts/Locations v116
Study sites197→201
2024-08-01
Study Status, Contacts/Locations, References v115
Study sites197 entries, revised
LocalThe InstitutionFirst Affiliated Hospital of Wenzhou Medical University Pan American Center for Oncology Trials - 0115 Local Institution - 0316Ciudadela
2024-07-31
Study Status, Contacts/Locations v114
Study sites197 entries, revised
LocalKanazawa InstitutionUniversity - 0300Hospital
2024-07-30
Study Status, Contacts/Locations v113
Study sites197 entries, revised
LocalPécsi InstitutionTudományegyetem -Klinikai 0036Központ
The purpose of the study is to compare Mezigdomide (CC-92480/BMS-986348) with carfilzomib and dexamethasone (MeziKD) against carfilzomib and dexamethasone (Kd) in the treatment of RRMM: SUCCESSOR-2.
Trial Details
NCT Number NCT05552976
Lead Sponsor Bristol-Myers Squibb
Conditions Relapsed or Refractory Multiple Myeloma
Enrollment 606 participants
Start Date 2023-01-10
Primary Completion 2026-09-28 (estimated)
Study Completion 2029-07-25 (estimated)
Updated on ClinicalTrials.gov 2026-09-24