| Detected | Trial | Change |
|---|---|---|
| 2026-06-12 | NCT07599345 Emulation of the EMPEROR-Reduced Trial Using Healthcare Claims Data |
Primary endpoint(s) modified |
| 2026-06-12 | NCT07417631 Emulation of the REWIND Cardiovascular Outcomes Trial in Healthcare Claims Data. |
Primary endpoint(s) modified |
| 2026-06-12 | NCT07417631 Emulation of the REWIND Cardiovascular Outcomes Trial in Healthcare Claims Data. |
Enrollment increased: 30000 -> 300000 participants |
| 2026-06-12 | NCT07417631 Emulation of the REWIND Cardiovascular Outcomes Trial in Healthcare Claims Data. |
date change Primary completion pushed: 2026-03 -> 2026-06-15 |
| 2026-06-12 | NCT07417631 Emulation of the REWIND Cardiovascular Outcomes Trial in Healthcare Claims Data. |
date change Completion pushed: 2026-03 -> 2026-06-15 |
| 2026-06-12 | NCT07599293 Emulation of the EMPEROR-Preserved Trial Using Healthcare Claims Data |
Primary endpoint(s) modified |
| 2026-05-14 | NCT07417618 INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without… |
Primary endpoint(s) modified |
| 2026-05-14 | NCT07417618 INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without… |
date change Primary completion pushed: 2026-03 -> 2026-05-22 |
| 2026-05-14 | NCT07417618 INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without… |
date change Completion pushed: 2026-03 -> 2026-05-22 |
| 2026-05-14 | NCT07365592 Neoadjuvant Chemotherapy, Anti-PD-1 Antibody and Sitagliptin for Locally Advanced pMMR CRC |
Recruitment opened |
| First Posted | Trial | Phase | Status |
|---|---|---|---|
| 2026-06-08 | NCT07634380 Sitagliptin With Pembro in RCC and Melanoma | Phase 1 | Not Yet Recruiting |
| 2026-06-05 | NCT07628556 Antidiabetic Medications and Risk of Cancer | Completed | |
| 2026-05-20 | NCT07599293 Emulation of the EMPEROR-Preserved Trial Using Healthcare Claims Data | Active, Not Recruiting | |
| 2026-05-20 | NCT07599345 Emulation of the EMPEROR-Reduced Trial Using Healthcare Claims Data | Active, Not Recruiting |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 4 | |||
| NCT04323189 | Effects of Sitagliptin in Individuals With Genetically Decreased DPP4 | Genetics Disease | Active, Not Recruiting |
| NCT06851962 | Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes. | Diabetes Mellitus Type 2 | Active, Not Recruiting |
| NCT07436663 | Comparative Study Between (SGLT-2i) and (DPP-4i) in the Prevention of DIC | Breast Cancer | Not Yet Recruiting |
| NCT05195944 | Semaglutide vs Sitagliptin | Liver Transplant; Complications | Enrolling by Invitation |
| Phase 3 | |||
| NCT06246799 | Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent… | Type 2 Diabetes (Adult Onset) | Recruiting |
| Phase 2 | |||
| NCT07003542 | A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4… | Glioblastoma | Recruiting |
| Phase 1/2 | |||
| NCT07374328 | Triple Hypoglycemic Regimens In Patients With Newly Diagnosed Type 2 Diabetes Mellitus | Type 2 Diabetes | Recruiting |
| NCT07365592 | Neoadjuvant Chemotherapy, Anti-PD-1 Antibody and Sitagliptin for Locally Advanced pMMR CRC | Colorectal Cancer | Recruiting |
| Phase 1 | |||
| NCT07567781 | A Phase 1 Study to Assess the Effect of ABBV-722 on Midazolam, Digoxin, Pitavastatin… | Healthy Volunteers | Recruiting |
| NCT07541781 | Sitagliptin in Recurrent/Progressive Grade 4 Glioma | Glioma | Not Yet Recruiting |
| NCT07634380 | Sitagliptin With Pembro in RCC and Melanoma | Advanced Renal Cell Carcinoma | Not Yet Recruiting |
| Not specified | |||
| NCT05313529 | LIGHT-MCI Trial: GLP-1 Agonist, SGLT2 Inhibitor, and DPP-4 Inhibitor for MCI Remission in… | Type 2 Diabetes Mellitus | Active, Not Recruiting |
| NCT03363464 | Comparative Effectiveness of Empagliflozin in the US | Diabetes Mellitus, Type 2 | Active, Not Recruiting |
| NCT07417618 | INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without… | Type 2 Diabetes | Active, Not Recruiting |
| NCT05220917 | Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in… | Cardiovascular Events | Active, Not Recruiting |
| NCT07390110 | Comparative Effectiveness of Oral Semaglutide vs Sitagliptin Among Individuals With Heart… | Type 2 Diabetes | Active, Not Recruiting |
| NCT07417631 | Emulation of the REWIND Cardiovascular Outcomes Trial in Healthcare Claims Data. | Type 2 Diabetes | Active, Not Recruiting |
| NCT07599293 | Emulation of the EMPEROR-Preserved Trial Using Healthcare Claims Data | Heart Failure With Preserved Ejection Fraction | Active, Not Recruiting |
| NCT07599345 | Emulation of the EMPEROR-Reduced Trial Using Healthcare Claims Data | Heart Failure With Reduced Ejection Fraction | Active, Not Recruiting |