Disease landscape

Heart Failure clinical trials

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1,435 active trials 825 recruiting 76 Phase 3 758 sponsors 229 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 65 of 229 changes on 20 trials

2026-07-31
Trial terminated
Trial terminated: Participant follow-up through 12 months post-Barostim Implant sufficient for data collection and analysis purposes.
Enrollment reduced: 5000 → 435 participants
Primary completion moved earlier: 2028-06 → 2026-05-14
Completion moved earlier: 2028-06 → 2026-06-30
NCT04502316 Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE… · CVRx, Inc.
2026-07-31
Trial status changed: Not Yet Recruiting → Terminated
Trial terminated: Recruitment too slow
Enrollment reduced: 100 → 9 participants
Primary completion moved earlier: 2026-09-01 → 2026-03-01
Completion moved earlier: 2026-09-01 → 2026-03-01
NCT06702527 Optimizing Clinical Outcomes in Patients Undergoing Mitral Transcatheter Edge-to-edge… · Institut für Pharmakologie und Präventive Medizin
2026-07-30
Trial status changed: Enrolling by Invitation → Terminated
Trial terminated: Difficulty with accrual.
Enrollment reduced: 40 → 6 participants
Primary completion moved earlier: 2026-03 → 2025-11-18
Completion moved earlier: 2027-03 → 2025-11-18
NCT05816265 Effects of IV Iron Replacement on Exercise Capacity in Individuals With Heart Failure · Radha Gopalan · Phase 4
2026-08-04
Recruitment suspended
Recruitment suspended: PI Request
NCT02962661 Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients… · M.D. Anderson Cancer Center · Phase 1
2026-08-05
Trial status changed: Enrolling by Invitation → Withdrawn
Trial withdrawn: PI no longer with the site
Enrollment reduced: 400 → 0 participants
NCT05224557 Analysis of Cardiac Biomarker Racial Discrepancies · Methodist Health System
2026-08-18
Primary completion pushed: 2027-09 → 2029-01
Phase changed: Phase 1 → Phase 1/2
Recruitment opened
Enrollment increased: 40 → 126 participants
Completion pushed: 2028-09 → 2030-01
NCT07123779 HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With… · 35Pharma Inc · Phase 1/2
2026-08-22
Primary completion pushed: 2026-05 → 2026-11
Enrollment closed, study ongoing
Completion pushed: 2026-11 → 2027-12
NCT06682910 Assessment of Safety and Accuracy of the Microtech System in Patients Undergoing Left… · Microtech Medical Technologies, Ltd
2026-08-26
Primary completion pushed: 2026-07 → 2028-07-16
Completion pushed: 2027-05 → 2028-07-16
NCT06601465 COgnitioN With VERiciGuat Evaluation in Heart Failure · University of Alberta · Phase 2
2026-08-27
Primary completion pushed: 2026-02-28 → 2027-02-28
Completion pushed: 2026-02-28 → 2027-02-28
NCT03876223 Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF · Cedars-Sinai Medical Center
2026-08-27
Primary completion pushed: 2026-05-01 → 2026-11-01
Completion pushed: 2026-07-01 → 2027-01-01
NCT07435662 Optimizing Heart Failure Therapies Among Patients With Limited Access in Denver · Denver Health and Hospital Authority
2026-08-06
Primary completion pushed: 2026-03-01 → 2026-07-31
Enrollment reduced: 54 → 30 participants
Trial completed
Completion pushed: 2026-04-01 → 2026-07-31
NCT06359938 Respiratory Sinus Arrhythmia (RSA) Pacing Post-CABG Surgery in Patients With HFrEF · Ceryx Medical Ltd
2026-08-05
Primary completion pushed: 2027-01 → 2028-01
Completion pushed: 2027-08 → 2028-08
NCT05677100 Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure · Procyrion
2026-08-04
Primary completion pushed: 2026-07 → 2027-10
Enrollment closed, study ongoing
Completion pushed: 2027-07 → 2027-10
NCT05839730 Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction · Medtronic Cardiac Rhythm and Heart Failure
2026-08-22
Primary completion pushed: 2026-07 → 2027-02
Enrollment reduced: 20 → 18 participants
Trial status changed: Enrolling by Invitation → Recruiting
Completion pushed: 2026-07 → 2027-11
NCT05585125 A Preliminary Study for INFORMED · Weill Medical College of Cornell University · Phase 4
2026-08-22
Primary completion pushed: 2025-05 → 2026-03-06
Enrollment reduced: 176 → 63 participants
Trial completed
Completion pushed: 2025-08 → 2026-04-07
NCT06528561 Impact of a Physical Exercise Program on the Self-care Capacity of People Hospitalized… · Centro Hospitalar Universitário de Santo António
2026-08-21
Primary completion pushed: 2026-11 → 2027-08
Completion pushed: 2026-11 → 2027-08
NCT06195059 Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume · Mayo Clinic
2026-08-12
Primary completion pushed: 2026-04-30 → 2027-04-30
Trial sites expanded: 9 → 12 locations
Completion pushed: 2026-06-30 → 2027-06-30
NCT07038356 Effects of Continued Administration of Empagliflozin in Patients With Heart Failure on… · Christian Schulze · Phase 3
2026-08-08
Primary completion pushed: 2028-12-01 → 2029-04
Primary endpoint(s) modified
Trial sites expanded: 0 → 10 locations
Completion pushed: 2029-03-01 → 2029-04
NCT07569640 HFrEF Polypill in Sri Lanka RCT · Washington University School of Medicine · Phase 3
2026-08-06
Primary completion pushed: 2030-08-01 → 2030-11-01
Completion pushed: 2030-10-01 → 2030-12-01
NCT07725484 Efficacy of Lipoic Acid on Chronic Ischemic Heart Failure Patients · Shanghai Zhongshan Hospital · Phase 3
2026-08-01
Primary completion pushed: 2027-03 → 2028-08
Enrollment reduced: 666 → 488 participants
Completion pushed: 2027-06 → 2028-12
NCT05508035 The Effect of Sacubitril/Valsartan Versus Ramipril on Left Ventricular Function and… · John Paul II Hospital, Krakow · Phase 3

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07791407 Magnetic Resonance Imaging Based Risk Stratification for Defibrillator Implantation in… Velammal Medical College Hospital and Research Institute new
2026-08-26 NCT07787936 GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry Miedziowe Centrum Zdrowia SA new
2026-08-25 NCT07784712 Right Ventricular Septal Biopsy to Detect Cardiac Amyloidosis Geisinger Clinic new
2026-08-24 NCT07781462 Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment… Alexandria University new Phase 4
2026-08-18 NCT07771231 Kosmos PLAX EF Pivotal Study EchoNous Inc. new
2026-08-18 NCT07770737 Cardioprotective Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Korean… Dongtan Sacred Heart Hospital new
2026-08-14 NCT07766109 Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery University Hospital, Toulouse new Phase 4
2026-08-13 NCT07762560 Routine Microaxial Heart Pump Support and Protocolized Pulmonary Artery Catheter… Leipzig Heart Science gGmbH new
2026-08-13 NCT07763353 Effects of Slow-paced Breathing on Heart Rate Variability in Patients With Heart Failure Chung Shan Medical University new
2026-08-13 NCT07762521 Bedside NT-proBNP Monitoring in Acute Heart Failure Mao Chen new

Active trials by phase

Early Phase 1
11
Phase 1
28
Phase 1/2
25
Phase 2
64
Phase 2/3
12
Phase 3
64
Phase 4
81
Not charted: 1,150 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,435

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07554638 Incretin Therapies in Obesity-related HFpEF Columbia University Recruiting 2026-08-24
NCT05585125 A Preliminary Study for INFORMED Weill Medical College of Cornell University Recruiting 2026-08-21
NCT05276219 DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure Rigshospitalet, Denmark Recruiting 2026-08-17
NCT06166654 Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload Johannes Grand Recruiting 2026-08-14
NCT07178145 Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction University of Virginia Recruiting 2026-08-11
NCT07397650 Efficacy and Safety With Early Treatment of Finerenone in Hospitalized Patients With… Juntendo University Recruiting 2026-08-10
NCT07482943 The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After… The University of Hong Kong Recruiting 2026-07-28
NCT06183437 The STOP-MED CTRCD Trial Dinesh Thavendiranathan Recruiting 2026-07-07
NCT07577596 Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure University of Aarhus Recruiting 2026-07-06
NCT06704633 Sacubitril-valsartan in Patients With Heart Failure With Reduced Ejection Fraction From… Martin Rohacek Recruiting 2026-07-02
NCT07490067 Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol… University of Michigan Recruiting 2026-06-30
NCT05672836 ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter… Duk-Woo Park, MD Recruiting 2026-06-29
NCT05793996 The Prevalence of Iron Deficiency and the Effectiveness of Ferinject® in Patients With… Tomsk National Research Medical Center of the Russian Academy of Sciences Recruiting 2026-06-24
NCT06979726 Gator SCALES-WHF: SubCutaneous Administration of Lasix to Eliminate Symptoms of Worsening… University of Florida Recruiting 2026-06-08
NCT07321509 Digoxin After Acute Heart Failure (DIG-DICA) Hospital General de Agudos "Dr. Cosme Argerich" Recruiting 2026-06-02
NCT07572032 Delayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected Aetiology… Kyungsub Song Recruiting 2026-06-01
NCT07617376 Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions Wroclaw Medical University Recruiting 2026-06-01
NCT07527156 Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure Institute for Clinical and Experimental Medicine Recruiting 2026-04-14
NCT07263035 Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure Lakeland Regional Health Systems, Inc. Recruiting 2026-04-09
NCT07513883 The Assessment of Partial Guideline-Directed Medical Therapy Down Titration in Heart… Ziekenhuis Oost-Limburg Recruiting 2026-04-07
NCT07147114 Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of… Gachon University Gil Medical Center Recruiting 2026-04-03
NCT06055452 Effects of SGLT2 Inhibitors in Pre-heart Failure Populations With Hypertension China National Center for Cardiovascular Diseases Recruiting 2026-03-05
NCT07405944 Vericiguat and Reverse Remodeling Indices in Heart Failure University Medical Centre Ljubljana Recruiting 2026-02-12
NCT07259512 Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease… Evi Liliek Wulandari Recruiting 2025-12-10
NCT06260059 Efficacy Of Sodium Glucose Transporter Inhibitor (SGLT2I) In Adult Patients With… Anita Saraf Recruiting 2025-10-06
See all 1,435 active Heart Failure trials with filters →

Top sponsors by active trials in this area

Mayo Clinic (16) · Yale University (13) · Brigham and Women's Hospital (11) · University of Texas Southwestern Medical Center (11) · Duke University (10) · Massachusetts General Hospital (10) · National Taiwan University Hospital (10) · The Cleveland Clinic (10) · Assistance Publique - Hôpitaux de Paris (9) · University Medical Center Groningen (9)

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