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NCT05816265 · ClinicalTrials.gov record · last posted 2026-07-29

Effects of IV Iron Replacement on Exercise Capacity in Individuals With Heart Failure

StatusTerminated
PhasePhase 4
Started2024-01-24
View on ClinicalTrials.gov ↗
Why the trial stopped
Difficulty with accrual.
from the ClinicalTrials.gov record
Patients with heart failure with reduced ejection fraction and iron deficiency will be randomized to either receive iron infusion or be in the control group. The study is looking at how iron replacement affects exercise capacity as measured by peak oxygen uptake.

Protocol amendment history 5 changes detected by DataLookout

2026-07-30
Trial status changed: Enrolling by Invitation → Terminated
2026-07-30
Trial terminated: Difficulty with accrual.
2026-07-30
Enrollment reduced: 40 → 6 participants
2026-07-30
Primary completion moved earlier: 2026-03 → 2025-11-18
2026-07-30
Completion moved earlier: 2027-03 → 2025-11-18
Trial Details
NCT Number NCT05816265
Lead Sponsor Radha Gopalan
Collaborators: American Regent, Inc.
Conditions Heart Failure, Iron-deficiency
Enrollment 6 participants
Start Date 2024-01-24
Primary Completion 2025-11-18 (estimated)
Study Completion 2025-11-18 (estimated)
Updated on ClinicalTrials.gov 2026-07-29