Clinical Trial

Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery

Study acronym: DISCO
Not Yet Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
SGLT-2 inhibitors are recommended treatments for managing heart failure patients. In cases of surgery, it is recommended to stop the treatment 3 days before surgery due to the risk of postoperative euglycemic diabetic ketoacidosis. However, several data suggest that it may be beneficial to maintain SGLT-2i treatment given the possibility of improving postoperative cardiovascular outcomes. Investigator team wish to conduct a randomized controlled trial to test the hypothesis that preoperative maintenance of SGLT-2i is superior to discontinuing them 3 days before surgery in improving postoperative cardiovascular outcomes.
Trial Details
NCT Number NCT07766109
Lead Sponsor University Hospital, Toulouse
Conditions Heart Failure, Cardiac Surgery
Enrollment 434 participants
Start Date 2026-10
Primary Completion 2029-01 (estimated)
Study Completion 2029-01 (estimated)
Updated on ClinicalTrials.gov 2026-08-14