Disease landscape

Glioma clinical trials

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554 active trials 327 recruiting 29 Phase 3 307 sponsors 56 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 35 of 56 changes on 20 trials

2026-08-26
Recruitment suspended
Recruitment suspended: Drug Supply Issues
NCT04870944 CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors… · Children's Oncology Group · Phase 1/2
2026-08-18
Recruitment suspended
Recruitment suspended: On hold per study team
NCT05607407 Methimazole in Patients With Progressive Glioblastoma · Case Comprehensive Cancer Center · Phase 2
2026-08-28
Primary completion pushed: 2025-12 → 2026-12
NCT04794972 A Study of GNC-039, a Tetra-specific Antibody, in Participants With Relapsed/Refractory… · Sichuan Baili Pharmaceutical Co., Ltd. · Phase 1
2026-08-27
Primary completion pushed: 2026-07-01 → 2028-01-01
Completion pushed: 2028-07-01 → 2029-07-01
NCT03048084 Seizure Treatment in Glioma · Leiden University Medical Center · Phase 4
2026-07-30
Primary completion pushed: 2026-09-30 → 2027-09-30
Completion pushed: 2026-10-31 → 2027-10-31
NCT05023551 Study of DSP-0390 in Patients With Recurrent High-Grade Glioma · Sumitomo Pharma America, Inc. · Early Phase 1
2026-08-25
Primary completion pushed: 2027-05-11 → 2027-08-20
Completion pushed: 2027-05-11 → 2028-07-20
NCT04214392 Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the… · City of Hope Medical Center · Phase 1
2026-07-31
Primary completion pushed: 2025-04-14 → 2026-04-22
Completion pushed: 2026-09-12 → 2027-05-27
NCT03598244 Savolitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors · National Cancer Institute (NCI) · Phase 1
2026-08-18
Primary completion pushed: 2026-03-05 → 2027-07-01
Enrollment closed, study ongoing
Completion pushed: 2027-03-05 → 2027-07-01
NCT06632236 5G-EMERALD: Amivantamab in Malignant Brain Tumours · Institute of Cancer Research, United Kingdom · Phase 1
2026-08-26
Primary endpoint(s) modified
NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… · Lumina Pharmaceuticals Inc · Early Phase 1
2026-08-01
Primary completion pushed: 2030-05 → 2030-11
Completion pushed: 2037-05 → 2037-11
NCT07206849 Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) · Nationwide Children's Hospital · Phase 2
2026-08-18
Primary completion pushed: 2026-12 → 2027-12
Completion pushed: 2026-12 → 2027-12
NCT05212272 MRI in High-Grade Glioma Patients Undergoing Chemoradiation · Wake Forest University Health Sciences
2026-08-12
Primary completion pushed: 2025-12 → 2027-08
Completion pushed: 2039-12 → 2042-08
NCT05544526 CAR T Cells to Target GD2 for DMG · University College, London · Phase 1
2026-08-19
Primary endpoint(s) modified
NCT07767110 Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response · NanOlogy, LLC · Phase 1/2
2026-08-07
Primary completion pushed: 2026-06-30 → 2027-06-30
Completion pushed: 2026-06-30 → 2027-06-30
NCT05086497 WBSI Guided Personalized Delivery of TTFields · Abramson Cancer Center at Penn Medicine
2026-08-25
Primary endpoint(s) modified
NCT07778979 Multiparametric Metabolic and Hypoxic PET/MRI Imaging Substudy in Gliomas · University of Alabama at Birmingham · Early Phase 1
2026-08-01
Primary endpoint(s) modified
NCT07628634 Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/… · University of California, Irvine · Early Phase 1
2026-08-11
Primary endpoint(s) modified
Enrollment increased: 120 → 202 participants
Trial arms changed: 1 → 3
NCT07074756 A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in… · Mayo Clinic
2026-08-18
Recruitment opened
NCT07243340 A Phase I/IIa Study of C5252 in Patients With Intracranial Tumor · ImmVira Pharma Co. Ltd · Phase 1/2
2026-08-28
Trial status changed: Recruiting → Not Yet Recruiting
Completion pushed: 2030-04-30 → 2030-06-30
NCT07501156 H3K27M-specific Immune Effector Cells Targeting DMG/DIPG · Shenzhen Geno-Immune Medical Institute · Phase 1/2
2026-08-11
Recruitment opened
NCT07286292 Vorasidenib Study in Pediatric Participants With Grade 2 Astrocytoma or Oligodendroglioma… · Institut de Recherches Internationales Servier (I.R.I.S.) · Phase 2

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07789678 A Single-arm Observational Study to Characterize the Epidemiological Profile of Patients… Latin American Cooperative Oncology Group new
2026-08-26 NCT07788677 Tarlatamab Treatment Before and After Surgery in Surgically Resectable Recurrent… Vall d'Hebron Institute of Oncology new Phase 1
2026-08-24 NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… Lumina Pharmaceuticals Inc new Early Phase 1
2026-08-21 NCT07778602 Safety and Feasibility of First-line Avutometinib and Defactinib in Patients With Newly… Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins new Early Phase 1
2026-08-17 NCT07767110 Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response NanOlogy, LLC new Phase 1/2
2026-08-10 NCT07755397 First in Human Multicenter Open Name Dose-increase, Consolidation Method to Study Safety… Jubilant Therapeutics India Limited new Phase 1
2026-08-10 NCT07754734 STUPP Regimen With or Without Lenvatinib for Newly Diagnosed Glioblastoma With MGMT… Dongguan People's Hospital new Phase 2
2026-08-07 NCT07751744 Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in… Jubilant Therapeutics Inc. new Phase 1/2
2026-08-06 NCT07750457 Proton vs. Photon Radiotherapy for Patients With WHO Grade 2-3 Glioma University Hospital, Essen new
2026-07-28 NCT07731555 Characterization of the Blood-Brain Barrier in High-Grade Glioma Through… Patrick Morris new

Active trials by phase

Early Phase 1
38
Phase 1
119
Phase 1/2
51
Phase 2
97
Phase 2/3
5
Phase 3
24
Phase 4
7
Not charted: 213 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 554

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT03048084 Seizure Treatment in Glioma Leiden University Medical Center Recruiting 2026-08-26
NCT03340506 Dabrafenib and/or Trametinib Rollover Study Novartis Pharmaceuticals Recruiting 2026-08-25
NCT07486713 Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies Rigel Pharmaceuticals Recruiting 2026-08-11
NCT04081701 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive… Weill Medical College of Cornell University Recruiting 2025-11-21
NCT05702944 The Effect and Safety of Omitting Preoperative Alpha-adrenergic Blockade for Normotensive… Seoul National University Hospital Recruiting 2025-06-12
NCT03975829 Pediatric Long-Term Follow-up and Rollover Study Novartis Pharmaceuticals Active, Not Recruiting 2026-08-27
NCT02496988 Effect of Cytokine-induced Killer Cells for Advanced Malignant Gliomas The First People's Hospital of Changzhou Not Yet Recruiting 2015-07-14
Phase 3
NCT04166409 A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With… National Cancer Institute (NCI) Recruiting 2026-08-24
NCT05476939 Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0 Gustave Roussy, Cancer Campus, Grand Paris Recruiting 2026-08-13
NCT06888817 Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic… The Netherlands Cancer Institute Recruiting 2026-07-13
NCT05303519 SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance) Nuvation Bio Inc. Recruiting 2026-07-01
NCT05271240 Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With… Northwell Health Recruiting 2026-06-01
NCT05580562 ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study) Jazz Pharmaceuticals Recruiting 2026-04-16
NCT06496971 A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab… NaviFUS Corporation Recruiting 2026-04-09
NCT05331521 A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly… University Hospital Heidelberg Recruiting 2026-02-03
NCT04702581 A Randomized Trial of Delayed Radiotherapy in Patients Low-grade Oligodendrogliomas… Hospices Civils de Lyon Recruiting 2026-01-29
NCT05512403 Evaluation of Diagnostic Performances of 18F-FDOPA PET KInetics Central Hospital, Nancy, France Recruiting 2024-09-19
NCT06330337 Effect of Electroacupuncture Combined With Paclitaxel Clinical Efficacy of Patients With… The Third Affiliated hospital of Zhejiang Chinese Medical University Recruiting 2024-03-26
NCT01649830 Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Glioma Sun Yat-sen University Recruiting 2020-05-28
NCT03871257 A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With… National Cancer Institute (NCI) Active, Not Recruiting 2026-08-13
NCT07712757 Safety and Efficacy Study of Safusidenib in Participants With Grade 2 IDH1-Mutant Glioma Nuvation Bio Inc. Not Yet Recruiting 2026-07-17
NCT07698457 Clinical Benefit of 18F-FET in Glioma. Primo Biotechnology Co., Ltd Not Yet Recruiting 2026-07-13
NCT04576117 A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and… National Cancer Institute (NCI) Active, Not Recruiting 2026-07-02
NCT06780930 Phase 3 Study of Vorasidenib (S095032/AG-881) in Asian Participants With Residual or… Servier Active, Not Recruiting 2026-06-04
NCT05566795 DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma… Day One Biopharmaceuticals, Inc. Active, Not Recruiting 2026-05-14
See all 554 active Glioma trials with filters →

Top sponsors by active trials in this area

National Cancer Institute (NCI) (36) · M.D. Anderson Cancer Center (15) · Mayo Clinic (12) · Nationwide Children's Hospital (11) · Beijing Tiantan Hospital (8) · Memorial Sloan Kettering Cancer Center (8) · Tata Memorial Centre (8) · University of California, San Francisco (8) · St. Jude Children's Research Hospital (6) · The First Affiliated Hospital of Zhengzhou University (6)

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